新加入上�？萍即髮W(xué)生命科學(xué)與技術(shù)學(xué)院的李夏軍研究組擬招聘一名博士后。本研究組主要研究遺傳學(xué)和表觀遺傳學(xué)，干細胞和發(fā)育生物學(xué)。我們的實驗室發(fā)現(xiàn)跟印記基因調(diào)控有關(guān)的主要因子ZFP57 (see Dev. Cell 15, 547－557)。我們第一次在哺乳動物里發(fā)現(xiàn)母本和合子的功能同時缺失導(dǎo)致胚胎死亡的現(xiàn)象。我們的論文已被引用300多次。在此基礎(chǔ)上我們研究了ZFP57在小鼠胚胎，胚胎干細胞和誘導(dǎo)干細胞里維持印記基因正常表達的作用。近來我們發(fā)現(xiàn)ZFP57母本和合子的功能也維持印記基因在心臟里的正常表達 (see PNAS 112(16): E2020-9)。ZFP57的缺失影響重要的NOTCH信號傳遞和心臟發(fā)育。希望更詳細了解我們工作的申請人請查看李夏軍實驗室在美國西奈山醫(yī)學(xué)院的網(wǎng)頁：http://icahn.mssm.edu/profiles/xiajun-john-li 

一、崗位職責(zé)：
       1) 獨立承擔(dān)部分實驗室的研究項目并參與指導(dǎo)研究生的日常研究工作；
       2) 協(xié)助PI處理研究相關(guān)事務(wù)，包括實驗室日常管理和維護，基金申請，項目相關(guān)的業(yè)務(wù)委托與合作交流。 

二、應(yīng)聘條件： 

1） 具有生物學(xué)有關(guān)專業(yè)的博士學(xué)位或即將被授予博士學(xué)位。 

2） 應(yīng)有扎實的遺傳學(xué)，表觀遺傳學(xué)，分子生物學(xué)，細胞或發(fā)育生物學(xué)研究基礎(chǔ)。 

3） 有端正的工作態(tài)度和認真負責(zé)的工作精神。 

4） 有良好的英語基礎(chǔ)。 

     上�？萍即髮W(xué)提供良好的工作環(huán)境和生活待遇。請感興趣并符合這些條件的申請人通過人才招聘系統(tǒng)（http://jobs.shanghaitech.edu.cn/）提交應(yīng)聘申請，或將個人中、英文簡歷發(fā)到: slst@shanghaitech.edu.cn, 郵件標題注明：應(yīng)聘某某崗位+本人姓名+中國博士人才網(wǎng)抄送：XL-2016@qq.com。請同時提供三個熟悉你的推薦人的名字和通訊方式（包括電話號碼和電子郵箱）。 

Research Summary 

The Li lab is interested in epigenetic regulation in stem cells with focus on genomic imprinting. Our lab discovered Zfp57 as a master regulator in genomic imprinting. Zfp57 is a maternal-zygotic effect gene and loss of Zfp57 causes maternal-zygotic embryonic lethality, the first one identified in mammals. Recently, we found both maternal and zygotic Zfp57 modulate NOTCH signaling in cardiac development.

Genomic imprinting is absolutely essential for mammalian development. Dysregulation of genomic imprinting causes a variety of human diseases including cancer, diabetes, cardiovascular diseases and neurological disorders. We are interested in modeling human diseases by utilizing Zfp57 mutant mice that we have generated previously. In addition, we will analyze the functions of Zfp57 in maintaining genomic imprinting in ES and iPS cells. Since genomic imprinting has been found to be unstable in these stem cells and loss of genomic imprinting will result in many human diseases, our research may lead to the strategies for derivation of ES and iPS cells with proper genomic imprinting that are suitable for future therapeutic applications.

Selected Publications: 

Lau H., Liu L. and Li X. (2016). Zfp57 mutant ES cell lines directly derived from blastocysts Stem Cell Research 16: 282-286.

Shamis Y., Cullen D., Liu L., Yang G., Ng S-F, Xiao L., Bell F., Ray C., Takikawa S., Moskowitz I., Cai C., Yang X. and Li X. (2015). Maternal and zygotic Zfp57 modulate NOTCH signaling in cardiac development. Proc Natl Acad Sci U S A 112(16): E2020-9.

Takikawa S., Ray C., Wang X., Shamis Y., Wu T. and Li X. (2013). Genomic imprinting is variably lost during reprogramming of mouse iPS cells. Stem Cell Research 11(2): 861-873.

Li X. (Invited paper) (2013). Genomic imprinting is a parental effect established in mammalian germ cells. Current Topics in Developmental Biology. 102:35-59.

Zuo X., Sheng J., Lau H., McDonald CM, Andrade M., Cullen DE, Bell FT, Iacovino M., Kyba M., Xu G. and Li X. (2012). The zinc finger protein ZFP57 requires its cofactor to recruit DNA methyltransferases and maintains the DNA methylation imprint in 
embryonic stem cells via its transcriptional repression domain. J. Biol. Chem. 287(3): 2107-18 (Epub 2011 Dec. 5)  (Highlighted in ESC &iPSC News, Top Story from Whitehead Institute).

Li X. *, Ito M., Zhou F., Youngson N., Zuo X., Leder P. and Ferguson-Smith, A. (2008). A maternal-zygotic effect gene, Zfp57, maintains both maternal and paternal imprints. Developmental Cell 15, 547-557 (*, sole corresponding author) (Previewed in Developmental Cell 15: 487-8, 2008). 

Postdoctoral Associate position available: 

The candidate must have a doctoral degree (PhD or MD) and has had strong previous research experiences in genetics, epigenetics, molecular biology, cell biology or developmental biology. ShanghaiTech University provides excellent working and living environment, with very competitive stipend. Please send your CV, together with the contact information of three referees who know you well, to the following email address: XL-2016@qq.com 

來源：

http://jobs.shanghaitech.edu.cn/job.asp?id=408

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