實(shí)驗(yàn)室研究方向：

T cells play essential roles in immune response. We are studying T cells with two directions:

1. Functional genomics in primary T cells

We are applying genome-wide CRISPR/Cas9 screen in primary T cell in vivo to answer fundamental questions in T cell biology, including development, activation, proliferation and differentiation, as well as T cell fitness (e.g. exhaustion) in tumor microenvironment.  Identified novel genes and regulatory circuits have been used to design novel therapies for diseases.

2. Mechanisms of metabolic regulation of T cells

Metabolic reprogramming is a hallmark of T cell activation, but how metabolic pathways regulate T cell function remains poorly understood. We are using mouse models with gain- and loss-of-function of key metabolic enzymes to decipher metabolic regulation T cell, and try to target metabolism to treat immune-related diseases.

近期代表性成果如下：

1. Min Peng, Na Yin, Ming O. Li. SZT2 dictates GATOR control of mTORC1 signaling. Nature. 2017 Mar 16;543(7645):433-437. 

2. Min Peng*, Na Yin*, Sagar Chhangawala, Ke Xu, Christina S. Leslie, Ming O. Li. Aerobic glycolysis promotes T helper 1 cell differentiation through an epigenetic mechanism. Science, 2016 Oct 28; 354(6311): 481-484. *equal contribution. 

Preview in Science, 2016 Oct 28; 354(6311): 419-420. “Warburg meets epigenetics”. 

Preview in Dev Cell, 2016 November 7;39: 286-287. “Metabolic Control of Cellular Differentiation”.

Preview in Cell Metab, 2016 November 8; 24: 651-652. “Metabolic Signaling Drives IFN-g”.

3. Min Peng, Na Yin, Ming O. Li. Sestrins Function as Guanine Nucleotide Dissociation Inhibitors for Rag GTPases to Control mTORC1 Signaling. Cell. 2014 Sep 25; 159(1): 122-33. 

Highlighted in Nat Rev Mol Cell Biol, 2014; 15: 701, “A RAG dissociation inhibitor”.

博士后 招聘1名： 

應(yīng)聘條件：

1）具有免疫學(xué)、分子和細(xì)胞生物學(xué)相關(guān)專業(yè)博士學(xué)位，獲得博士學(xué)位1年以內(nèi)

2）近3年以第一作者身份在國際知名學(xué)術(shù)期刊發(fā)表研究論文，符合清華大學(xué)博士后入站標(biāo)準(zhǔn) 

3）熱愛科研工作，責(zé)任心強(qiáng)，具備團(tuán)隊(duì)合作精神 

4）具備較好的英語溝通、閱讀和寫作能力 

崗位待遇：在清華大學(xué)博士后的標(biāo)準(zhǔn)薪酬和待遇基礎(chǔ)上，課題組支持博士后申請相應(yīng)獎(jiǎng)學(xué)金計(jì)劃。享受具有競爭力的薪酬資助和優(yōu)秀的科研環(huán)境。具體情況參見清華大學(xué)博士后申請相關(guān)網(wǎng)頁。

申請材料以及申請方式：

1） 個(gè)人簡歷（包括主要學(xué)習(xí)和研究經(jīng)歷、發(fā)表論文列表，參與項(xiàng)目、獎(jiǎng)勵(lì)等）

2） 個(gè)人英文陳述（包括詳細(xì)的個(gè)人研究興趣，主要研究成果和未來的職業(yè)規(guī)劃等）

3） 2-3位推薦人（其中一位應(yīng)為本人博士導(dǎo)師）的聯(lián)系方式

4） 申請材料發(fā)送至pengmin@tsinghua.edu.cn，主題標(biāo)明“姓名+應(yīng)聘博士后“

為防止簡歷投遞丟失請抄送一份至：boshijob@126.com（郵件標(biāo)題格式：應(yīng)聘職位名稱+姓名+學(xué)歷+專業(yè)+中國博士人才網(wǎng)）