深圳大學過敏反應與免疫學研究所楊平常教授、宋江平教授（國家杰青，北京協(xié)和醫(yī)學院長聘準聘教授，深圳大學醫(yī)學部兼職教授）、胡東生教授、徐大模教授、黃嘯谷教授團隊現(xiàn)因科研工作（國家自然科學基金重大項目、國家自然科學基金等）需要，現(xiàn)擬招聘博士后研究人員8-10名，具體要求如下：
研究方向1：心臟疾病免疫治療2-3人；
研究方向2：醫(yī)學免疫學（粘膜免疫）2-3人；
研究方向3：生物信息與分子流行病學；重大疾病綜合病因?qū)W及預測預警研究；多源多維健康大數(shù)據(jù)構(gòu)建與分析2-3人；
研究方向4：環(huán)境因素與過敏性疾病2人。
應聘條件（要求）：
（1）博士畢業(yè)生（含往屆和應屆生），外語通過六級；
（2）博士期間在核心刊物（SCI收錄）發(fā)表論文1篇以上；
（3）事業(yè)心和責任心強，年齡不超過35周歲，博士畢業(yè)不超過3年。
聘期待遇：
（1）參照國家人事部博士后有關待遇執(zhí)行；
（2）按深圳市政府博士后研究生資助規(guī)定，開題和中期考核合格后可向深圳市申請兩期補助，每期18萬元（稅后）；
（3）工資和津貼：40萬元以上/年（約43-50萬元/年）
（4）按深圳市政府有關規(guī)定，對出站后留深工作者給予30萬元科研啟動經(jīng)費；
（5）博士后人員進站，可自愿選擇落戶深圳市。選擇落戶深圳市的，其配偶及未成年子女可辦理隨遷入戶。博士后子女入托、入學等按深圳市相關條例執(zhí)行；
（6）出站后可優(yōu)先考慮或推薦事業(yè)單位（高校或醫(yī)院，尤其是留本院）工作；
（7）可以隨時到心血管疾病國家重點實驗室交流訪問。
聯(lián)系方式：
博士畢業(yè)生（含應屆生）可將個人簡歷送給研究助理龔苗收
聯(lián)系人：龔苗
手機號（同微信號）15914068577
E-mail: gm549605492@163.com
地址：廣東省深圳市南山區(qū)學苑大道1066號深圳大學麗湖校區(qū)A7棟511室
郵編：518055
深圳大學過敏反應與免疫學研究所
2023年04月13日
博士后合作導師簡介：
一、楊平常：男，醫(yī)學博士、特聘教授、博導；深圳大學過敏反應與免疫學研究所所長、呼吸疾病國家重點實驗室深圳大學變態(tài)反應分室主任、深圳市過敏反應與免疫學重點實驗室主任。原加拿大McMaster大學病理學系副教授；主要從事免疫調(diào)節(jié)、過敏反應發(fā)病原理和免疫耐受的研究工作30年，以第一作者和通訊作者在國際主流期刊發(fā)表論文超過200篇，包括J Clin Invest, Gastroenterology, Gut, JACI, Circulation等，其中20篇影響因子>10.0分；30余篇影響因子>5.0分，文章總引用率超過5000次。主持國家重大項目、國家基金面上項目以及省市級等科研課題多項，獲多項省市科技進步獎。
發(fā)表主要學術論文情況：
1．Lin J#, Huang N#, Li J#, Liu X#, Xiong Q, Hu C, Chen D, Guan L, Chang K, Li D, Tsui SK*, Zhong N*, Liu Z*, Yang PC*. Cross-reactive antibodies against dust mite-derived enolase induce neutrophilic airway inflammation. Eur Respir J, 2021;57(1):1902375.
2．Liu XY, Wu YJ, Song LJ, Zeng XH, Wang S, Liu JQ, Mo LH, Geng XR, Yang LT, Zhang XW*, Liu ZG*, Yang PC*. 3-methyl-4-nitrophenol regulates dendritic cell activities to facilitate the development of nasal allergy. J Allergy Clin Immunol. 2019;143(4):1614-1616.
3．Yang LT#, Shu Q#, Luo XQ#, Liu ZQ, Qiu SQ, Liu JQ, Guo HJ, Li LJ, Li MG, Liu DB, Xia LX, Liu ZG*, Yang PC*. Long-term effects: Galectin-1 and specific immunotherapy for allergic responses in the intestine. Allergy. 2018;73(1):106-114.
4．Liu XY, Xu LZ, Luo XQ, Geng XR, Liu ZQ, Yang LT, Yang G, Chen S, Liu ZG*, Li HB*, Yang LT, Luan TG*, Yang PC*. Forkhead box protein-3 (Foxp3)-producing dendritic cells suppress allergic response. Allergy. 2017;72(6): 908-917.
5．Yang G, Geng XR, Song JP, Wu YY, Yan H, Zhan Z, Yang L, He W, Liu ZQ, Qiu S, Liu Z*, Yang PC*. Insulin-like growth factor-2 enhances regulatory T cell functions and suppresses food allergy in an experimental model. J Allergy Clin Immunol. 2014;133(6): 1702-1708.
6．Wu W, Sun M, Zhang HP, Chen T, Wu R, Liu C, Yang G, Geng XR, Feng BS, Liu ZG, Liu Z*, Yang PC*. Prolactin mediates psychological stress-induced dysfunction of regulatory T cells to facilitate intestinal inflammation. Gut. 2014;63(12):1883-92.
7．He SH, Chen X, Song CH, Liu ZQ, Zhou LF, Ma WJ, Zhao LD, Li TL, Tang SG, Xing Z, Yang PC*. A novel interferon lambda-mediated pathway in establishment of oral tolerance and inhibition of antigen-specific Th2 polarized gut inflammation. Gastroenterology. 2011;141:249-258.
8．Zheng PY, Feng BS, Oluwole C, Struiksma S, Chen X, Li P, Tang SG, Johan D. Söderholm JD, Yang PC*. Psychological stress induces eosinophils to produce corticotrophin releasing hormone in the intestine. Gut. 2009;58:1473-9.
二、宋江平：男，醫(yī)學博士，北京協(xié)和醫(yī)學院長聘準聘教授（Tenure-track）, 深圳大學醫(yī)學部客座教授，中國醫(yī)學科學院阜外醫(yī)院心臟外科五病區(qū)副主任。國家杰出青年獲得者，北京杰青獲得者。近年來專注心血管免疫治療力求尋找到治療靶點，形成轉(zhuǎn)化。5年內(nèi)以第一作者或通訊作者發(fā)表論文62篇，包括Circulation（IF：29.69，5篇）、Eur Heart J（IF：29.98）、Nat Cell Biol（IF：28.82）、Sci Transl Med（IF：17.96）、Basic Res Cardiol（IF：17.17）、ATVB等。
發(fā)表主要學術論文情況：
1．Chen L, Hua K, Zhang N, Wang J, Meng J, Hu Z, Gao H, Li F, Chen Y, Ren J, Liu L, Zhou Q, Gu J, Song J*, Zhang X, Hu S. Multifaceted Spatial and Functional Zonation of Cardiac Cells in Adult Human Heart. Circulation 2022, 145: 315-318.
2．Song S, Tien CL, Cui H, Basil P, Zhu N, Gong Y, Li W, Li H, Fan Q, Min Choi J, Luo W, Xue Y, Cao R, Zhou W, Ortiz AR, Stork B, Mundra V, Putluri N, York B, Chu M, Chang J, Yun Jung S, Xie L, Song J*, Zhang L, Sun Z. Myocardial Rev-erb-Mediated Diurnal Metabolic Rhythm and Obesity Paradox. Circulation 2022, 145: 448-464.
3．Rao M, Wang X, Guo G, Wang L, Chen S, Yin P, Chen K, Chen L, Zhang Z, Chen X, Hu X, Hu S, Song J*. Resolving the intertwining of inflammation and fibrosis in human heart failure at single-cell level. Basic Res Cardiol. 2021;116(1):55.
4．Chang Y, Li X, Cheng Q, Hu Y, Chen X, Hua X, Fan X, Tao M, Song J*, Hu S. Single-cell transcriptomic identified HIF1A as a target for attenuating acute rejection after heart transplantation. Basic Res Cardiol. 2021;116(1):64.
5．Ren J, Tsilafakis K, Chen L, Lekkos K, Kostavasili I, Varela A, Cokkinos DV, Davos CH, Sun X, Song J*, Mavroidis M. Crosstalk between coagulation and complement activation promotes cardiac dysfunction in arrhythmogenic right ventricular cardiomyopathy. Theranostics . 2021;11(12):5939-5954.
6．Hu Z, Liu W, Hua X, Chen X, Chang Y, Hu Y, Xu Z, Song J*. Single-Cell Transcriptomic Atlas of Different Human Cardiac Arteries Identifies Cell Types Associated with Vascular Physiology. Arterioscler Thromb Vasc Biol 2021, 41(4): 1408-1427.
7．Li HW, Hu Z, Chen X, Ren J, Cui H, Zhang M, Chen L, Hua X, Song J*, Long YT. Investigation of Lipid Metabolism in Dynamic Progression of Coronary Artery Atherosclerosis of Humans by Time-of-Flight Secondary Ion Mass Spectrometry. Anal Chem 2021, 93(8): 3839-3847.
8．Cui H, Shu S, Li Y, Yan X, Chen X, Chen Z, Hu Y, Chang Y, Hu Z, Wang X, Song J*. Plasma Metabolites-Based Prediction in Cardiac Surgery-Associated Acute Kidney Injury. J Am Heart Assoc. 2021;10(22): e021825.
9．Song JP#, *, Chen L, Chen X, Ren J, Zhang NN, Tirasawasdichai T, Hu ZL, Hua W, Hu YR, Tang HR, Chen HV, Hu SS. Elevated plasma β-hydroxybutyrate predicts adverse outcomes and disease progression in patients with arrhythmogenic cardiomyopathy. Sci Transl Med 2020, 12(530).
10．Hua X, Hu G, Hu Q, Chang Y, Hu Y, Gao L, Chen X, Yang PC, Zhang Y, Li M, Song J*. Single-Cell RNA Sequencing to Dissect the Immunological Network of Autoimmune Myocarditis. Circulation 2020, 142(4): 384-400.
11．Wang L, Yu P, Zhou B, Song J#, Li Z, Zhang M, Guo G, Wang Y, Chen X, Han L, Hu S. Single-cell reconstruction of the adult human heart during heart failure and recovery reveals the cellular landscape underlying cardiac function. Nat Cell Biol 2020, 22(1): 108-119.
12．Dai Y, Song J#, *, Li W, Yang T, Yue X, Lin X, Yang X, Luo W, Guo J, Wang X, Lai S, Andrade KC, Chang J. RhoE Fine-Tunes Inflammatory Response in Myocardial Infarction. Circulation 2019, 139(9): 1185-1198.
13．Chen L, Song J#, *, Chen X, Chen K, Ren J, Zhang N, Rao M, Hu Z, Zhang Y, Gu M, Zhao H, Tang H, Yang Z, Hu S. A novel genotype-based clinicopathology classification of arrhythmogenic cardiomyopathy provides novel insights into disease progression. Eur Heart J 2019, 40(21): 1690-1703.
14．Chen X, Zeng XH, Wang M, Chen L, Zhang N, Rao M, Yang PC, Song J*. Bcl2-Like Protein 12 Is Required for the Aberrant T Helper-2 Polarization in the Heart by Enhancing Interleukin-4 Expression and Compromising Apoptotic Machinery in CD4+ T Cells. Circulation 2018, 138(22): 2559-2568.
三、胡東生：男，理學博士，博導，教授，深圳大學公共衛(wèi)生學院院長。主要研究方向為重大慢性病、傳染病流行規(guī)律及創(chuàng)新干預策略、健康城市理論與評價、循證公共衛(wèi)生決策。承擔國家科技支撐及重大科技專項分課題4項，國家自然科學基金面上項目5項，發(fā)表SCI收錄論文226篇（H-index歸屬深圳大學和鄭州大學分別為16和28），主編或參編國家級規(guī)劃教材及學術專著19部。教育部公共衛(wèi)生與預防醫(yī)學專業(yè)教學指導委員會委員，教育部國家級精品課程（流行病學）負責人，廣東省高校公共衛(wèi)生與預防醫(yī)學專業(yè)教學指導委員會委員，中國營養(yǎng)學會營養(yǎng)與慢病控制分會副主任委員，中國醫(yī)藥教育協(xié)會基層醫(yī)藥教育專業(yè)委員會副主任委員，中華預防醫(yī)學會環(huán)境衛(wèi)生學分會、心臟病預防與控制分會常務委員，流行病學分會委員，深圳市衛(wèi)健委首屆疫情防控公共衛(wèi)生專家組成員�！吨腥A疾病控制雜志》常務編委，《中華流行病學雜志》、《中華預防醫(yī)學雜志》和《衛(wèi)生研究》編委。
發(fā)表主要學術論文情況：
1．Dongsheng Hu, Barbara V. Howard, Jeffrey Henderson, Thomas K. Welty, Elisa T. Lee, Kathleen A. Jablonski. Glycemic control in diabetic American Indians: Longitudinal data from the Strong Heart Study. Diabetes Care 1999; 22(11): 1802-1807.
2．Dongsheng Hu, Kathleen A. Jablonski, Yvonne H. Sparling, David C. Robbins, Thomas K. Welty, Elisa T. Lee, Barbara V. Howard. Accuracy of lipoprotein lipids and apoproteins in predicting coronary heart disease in diabetic American Indians: The Strong Heart Study. Annals of Epidemiology 2002; 12(2): 79-85.
3．Dongsheng Hu, Jing Xie, Pengyu Fu, Jing Zhou, Dongfeng Gu. Central rather than overall obesity is related to diabetes in the Chinese population: The InterASIA Study. Obesity 2007; 15(11): 2809-2816.
4．Dongsheng Hu, DahaiYu. Epidemiology of cardiovascular diseases in Asian women. Nutrition, Metabolism & Cardiovascular Diseases 2010; 20 (6): 394-404.
5．Lu Zhang, Bingyuan Wang, Chongjian Wang, Linlin Li, Yongcheng Ren, Hongyan Zhang, Xiangyu Yang, Yang Zhao, Chengyi Han, Junmei Zhou, Xinping Luo, Dongsheng Hu*. High pulse pressure is related to risk of type 2 diabetes mellitus in Chinese middle-aged females. International Journal of Cardiology 2016; 220:467-471.
6．Ming Zhang, Yang Zhao, Haohang Sun, Xinping Luo, Chongjian Wang, Linlin Li, Lu Zhang, Bingyuan Wang, Yongcheng Ren, Junmei Zhou, Chengyi Han, Hongyan Zhang, Xiangyu Yang, Chao Pang, Lei Yin, Tianping Feng, Jingzhi Zhao, Dongsheng Hu*. Effect of dynamic change in body mass index on the risk of hypertension: Results from the Rural Chinese Cohort Study. International Journal of Cardiology 2017; 238: 117-122.
7．Yang Zhao, Ming Zhang, Xinping Luo, Chongjian Wang, Linin Li, Lu Zhang, Bingyuan Wang, Yongcheng Ren, Junmei Zhou, Chengyi Han, Chao Pang, Lei Yin, Tianping Feng, Jingzhi Zhao, Dongsheng Hu*. Association of 6-year waist circumference gain and incident hypertension. Heart 2017; 103(17): 1347-1352.
8．Ming Zhang, Bingyuan Wang, Yu Liu, Xizhuo Sun, Xinping Luo, Chongjian Wang, Linlin Li, Lu Zhang, Yongcheng Ren, Yang Zhao, Junmei Zhou, Chengyi Han, Jingzhi Zhao, Dongsheng Hu*. Cumulative increased risk of incident type 2 diabetes mellitus with increasing triglyceride glucose index in normal-weight people: The Rural Chinese Cohort Study. Cardiovascular Diabetology 2017; 16(1): 30. DOI: 10.1186/s12933-017-0514-x.
9．Chengyi Han, Yu Liu, Xizhuo Sun, Xinping Luo, Lu Zhang, Bingyuan Wang, Yongcheng Ren, Junmei Zhou, Yang Zhao, Dongdong Zhang, Xuejiao Liu, Ming Zhang, Dongsheng Hu*. Prediction of a new body shape index and body adiposity estimator for development of type 2 diabetes mellitus: The Rural Chinese Cohort Study. British Journal of Nutrition 2017; 118(10): 771-776.
10．Yongcheng Ren, Yu Liu, Xizhuo Sun, Bingyuan Wang, Yang Zhao, Dechen Liu, Dongdong Zhang, Xuejiao Liu, Ruiyuan Zhang, Haohang Sun, Feiyan Liu, Xu Chen, Cheng Cheng, Leilei Liu, Qionggui Zhou, Ming Zhang, Dongsheng Hu*. Chocolate consumption and risk of cardiovascular diseases: a meta-analysis of prospective studies. Heart 2019; 105(1): 49~55.
四、徐大模：男，免疫學博士，教授、博導，深圳大學醫(yī)學部教授，英國哥拉斯哥大學感染免疫和炎癥研究院終身高級研究員。1982畢業(yè)于吉林醫(yī)學院獲醫(yī)學學士學位；1988 獲白求恩醫(yī)科大學免疫學碩士學位；1994獲英國倫敦大學（King’s College, London, UK）免疫學博士學位。曾任腹部外科醫(yī)生，衛(wèi)生部長春生物制品研究所助理研究員，英國哥拉斯哥大學博士后研究員和研究員；研究領域是疾病的免疫調(diào)控。在過去25年里，共發(fā)表了110篇SCI研究論文，包括Nat Immunol，Nat Rev Immunol，JEM，PNAS和 JACI。總影響因子：674.98�？傄么螖�(shù)11014次，H-index：52。 8所大學、研究所的客座教授，受邀參加國際科學會議并做報告的次數(shù)超過20次。任多個SCI雜志的編委及特邀審稿人和基金會評委（包括英國哮喘病基金會）。
發(fā)表主要學術論文情況：
1．Brint EK*, D Xu*, H Liu, A Dunne, ANJ McKenzie, LAJ O’Neill and FY Liew. ST2 is an inhibitor of interleukin 1 receptor and Toll-like receptor 4 signaling and maintains endotoxin tolerance. Nature Immunology.2004.5:373-379.
2．Liew FY*, Xu D*, Brint EK, O'neill LA. Negative regulation of Toll-like receptor-mediated immune responses. Nat Rev Immunol. 2005. 5:446-58.
3．Xu, D., W.L. Chan, B.P. Leung, D.H. Hunter, K. Schulz, R.R. Carter, I.B. McInnes, J.H. Robinson and F.Y. Liew. Selective expression and functions of interleukin 18 receptor on T helper (Th) type 1 but not Th2 cells. J. Exp. Med. 1998. 188:1485-1492.
4．Xu, D., W.L. Chan, B.P. Leung, F.P. Huang, R. Wheeler, D. Piedrafita, J.H. Robinson and F.Y. Liew. Selective expression of a stable cell surface molecule on type 2 but not type 1 helper T cells . J. Exp. Med. 1998. 187:787-794.
5．Ashley M. Miller, Damo Xu*, Naveed Sattar, Andrew H. Baker, Iain B. McInnes and Foo Y. Liew*. IL-33 reduces the development of atherosclerosis. J. Exp. Med. 2008. 205(2):339-46.
6. Xu D*, Jiang HR, Kewin P, Li Y, Mu R, Fraser AR, Pitman N, Kurowska-Stolarska M, McKenzie AN, McInnes IB, Liew FY*.IL-33 exacerbates antigen-induced arthritis by activating mast cells. Proc Natl Acad Sci U S A. 2008. 105(31):10913-8.
7．Liu H, Komai-Koma M, Xu D* and Liew FY*. Toll-like Receptor (TLR) 2 signaling modulates the functions of CD4+CD25+ regulatory T cells. Proc Natl Acad Sci U S A. 2006. 103(18):7048-53
8．Komai-Koma M, Jones L, Ogg GS, Xu D*, Liew FY*. TLR2 is expressed on activated T cells as a costimulatory receptor. Proc Natl Acad Sci U S A. 2004. 101:3029-3034
9．Gao Xuzhu, Mousa Komai-Koma1, Bernard P. Leung, Hwee Siew Howe, Charles McSharry, Iain B. McInnes and Damo Xu*. Resveratrol modulates murine collagen-induced arthritis by inhibiting Th17 and B cell function. Ann. Rheum. Dise.2012, 71(1):129-35.
10．Dong Li, Rodrigo Guabiraba, Anne-Gaëlle Besnard, Mousa Komai-Koma, Majid S. Jabir, Li Zhang, Gerard J. Graham, Mariola Kurowska-Stolarska, Foo Y. Liew, Charles McSharry, Damo Xu*. IL-33 promotes ST2-dependent lung fibrosis by the induction of alternatively activated macrophages and innate lymphoid cells in mice. J Allergy Clin Immunol. 2014.134:1422-32.
五、黃嘯谷：男，免疫學博士、教授、博導；深圳大學醫(yī)學部教授，臺灣衛(wèi)生研究院環(huán)境醫(yī)學研究所特聘研究員，美國約翰霍普金斯大學醫(yī)學院哮喘和過敏反應中心終身教授。主要從事基因和環(huán)境因素在過敏性疾病的發(fā)病機制研究。主持國家級科研項目多項，在國際期刊發(fā)表200余篇，包括Nature Medicine, Blood, J Exp Med, J Immunol, JACI 等期刊。總引用次數(shù)10653，H 指數(shù): 54。獲省市科技進步二等獎各1項。
發(fā)表主要學術論文情況：
1．Wang LT, Lin MH, Liu KY, Chiou SS, Wang SN, Chai CY, Tseng LW, Chiou HC, Wang HC, Yokoyama KK, Hsu SH, Huang SK*. WLS/wntless is essential in controlling dendritic cell homeostasis via a WNT signaling-independent mechanism. Autophagy. 2021; 1-16.
2．Xu D, Huang SK*. IL-33: a key player in the development of iron-recycling red pulp macrophages. Cell Mol Immunol. 2020;17(12):1218-1219.
3．Suen JL, Wu TT, Li YH, Lee CL, Kuo FC, Yan PS, Wu CF, Tran M, Wang CJ, Hung CH, Wu MT, Chan MWY, Huang SK*. Environmental Factor-Mediated Transgenerational Inheritance of Igf2r Hypomethylation and Pulmonary Allergic Response via Targeting Dendritic Cells. Front Immunol. 2020;11:603831.
4．Wang HC, Wong TH, Wang LT, Su HH, Yu HY, Wu AH, Lin YC, Chen HL, Suen JL, Hsu SH, Chen LC, Zhou Y, Huang SK*. Aryl hydrocarbon receptor signaling promotes ORMDL3-dependent generation of sphingosine-1-phosphate by inhibiting sphingosine-1-phosphate lyase. Cell Mol Immunol. 2019;16(10):783-790.
5．Chen LC, Tseng HM, Kuo ML, Chiu CY, Liao SL, Su KW, Tsai MH, Hua MC, Lai SH, Yao TC, Yeh KW, Wu AH, Huang JL, Huang SK*. A composite of exhaled LTB4, LXA4, FeNO, and FEV1 as an "asthma classification ratio" characterizes childhood asthma. Allergy. 2018;73(3):627-634.
6．Zhou Y, Do DC, Ishmael FT, Squadrito ML, Tang HM, Tang HL, Hsu MH, Qiu L, Li C, Zhang Y, Becker KG, Wan M, Huang SK*, Gao P*. Mannose receptor modulates macrophage polarization and allergic inflammation through miR-511-3p. J Allergy Clin Immunol. 2018;141(1):350-364.
7．Lee CL, Huang HC, Wang CC, Sheu CC, Wu CC, Leung SY, Lai RS, Lin CC, Wei YF, Lai IC, Jiang H, Chou WL, Chung WY, Huang MS, Huang SK*. A new grid-scale model simulating the spatiotemporal distribution of PM2.5-PAHs for exposure assessment. J Hazard Mater. 2016;314:286-94.
8．Zhou YF, Kawasaki H, Hsu SC, Plunkett B, Lee RT, Yang KD, Lee YC, Huang SK*. Oral tolerance to food-induced systemic anaphylaxis mediated by the C-type lectin SIGNR1. Nature Medicine. 2010; 16:1128-1133.
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