Skirball Institute of Biomolecular Medicine - New York, NY
The Skolnik Lab at the Skirball Institute of Biomolecular Medicine seeks a Postdoctoral Fellow to assess changes in metabolism that arise in Autosomal-dominant polycystic kidney disease ( ADPKD ) and whether targeting these changes may provide novel treatment for this disease. ADPKD affects more than 12 million people worldwide and is a common cause of end-stage kidney disease. In the majority of cases, ADPKD is caused by mutations in one of two genes, PKD1 or PKD2, which are encoded by polycystin 1 (PC) and PC2 respectively. Loss of both copies of PC1 or PC2 is associated with cyst formation and cyst enlargement by stimulating the enhanced growth of renal epithelia. Over time, cysts become more numerous and larger in size and replace normal kidney tissue leading to loss of renal function.
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