The mechanisms underlying eukaryotic chemotaxis Prof Robert Insall
Starting Salary from £28,500 to £38,000 (Depending on experience) Initial 3 year fixed term contract (with possibility of up to 2 year extension)
Cancer Research UK Beatson Institute in Glasgow is one of Europe’s leading cancer research centres. It supports cutting edge research into the molecular mechanisms of cancer development. The Institute provides an outstanding research environment, underpinned by state-of-the-art core services and advanced technologies with special emphasis on imaging and proteomics.
This Cancer Research UK funded project will use multiple approaches to investigate the way eukaryotic cells connect gradients of extracellular signals to steering and migration of individual cells. The Insall laboratory approaches this problem using multiple experimental systems. It is envisaged this work will use a combination of Dictyostelium genetics and quantitative/computational analysis, though we are interested in general mechanisms, so findings will be confirmed in cultured mammalian cells and in vivo models. The work will focus on mechanisms that generate and promote the growth of new actin pseudopods (see Andrew & Insall, NCB 9, 193 & Ura et al., Curr Bio 22:553).. Techniques will involve some of: high-level microscopy on multiple platforms including TIRF, FRET/FLIM and FRAP, Dictyostelium growth & genetics, mammalian cell culture, analysis of microscopic data using ImageJ and MatLab, and computational modelling of the results
A relevant PhD is essential. Experience in microscopy, Java and/or MatLab programming, cell biology, molecular biology and genetics, and a good record of quality publications would be an advantage. You will have good knowledge of the literature, enthusiasm and flexibility to work on a wide range of techniques as needed.
Applications for the above posts should be sent with CV and names of three referees quoting RI2 tobeatson@beatson.gla.ac.uk at The Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow, G61 1BD, UK.
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