Post Doc Fellowship - Computational Chemistry Job

Job ID: 14193
Location: Bedford, MA
Offsite Territory:
Full/Part Time: Full-Time
Regular/Temporary: Temporary
Category: Other
Department: Computational Chemistry - 3273


Celgene Corporation is committed to delivering innovative therapies designed to improve the lives of patients worldwide. We are a global biopharmaceutical company with operations in more than 70 countries that is helping to turn incurable cancers into chronic, manageable conditions. We are seeking talented professionals as we continue to grow and advance our efforts in oncology, hematology and immune and inflammatory disease. If you would like to join a company where you can make a difference, please consider the Celgene family.

A completed Ph.D. in chemistry with focus on computational chemistry.

- Publication(s) in the area of application or development of molecular dynamics methodology.

Summary:

Located in Bedford, MA, Celgene Avilomics Research is seeking a postdoctoral fellow in the Informatics and Drug Design Department. The role will focus on the application of molecular dynamics and quantum chemistry to extend the understanding of structure and reactivity in covalent drug design.

Covalent drug design is at the forefront in drug research. The Celgene Avilomics Research site in Bedford, MA is a leader in this research area. This offers an exceptional learning environment to understand modern covalent drug design, and extend the boundaries with additional insights into the physical/chemical principles governing covalent approaches. It is anticipated that, through daily interaction with scientists, the incumbent will gain appreciation for the drug discovery process.

Technical Skill Requirements:

- Demonstrated skills in the application of computer-assisted molecular design using standard modeling and computational packages.

- Experience in the application of molecular dynamics to probe macromolecular systems of biological interest.

- Applicants must have significant programming experience in at least one scripting language (e.g., Perl, Python) and one programming language (Java, C, C++).

- Ability to independently analyze literature and project data.

- Excellent writing and communication skills.

Responsibilities:

The post-doctoral fellow will conduct analyses of factors governing the spatial proximity and likelihood of covalent adduct formation in protein-ligand complexes using molecular dynamics and quantum chemistry. As part of your studies, you will interrogate the role of ligand and protein flexibility as contributing factors to covalency and evaluate ways to position ligand electrophiles to improve the efficiency of covalent modification.

It is expected that you are or will become proficient with running molecular dynamics calculations in a high performance computing environment. You will be expected to design and program analytic tools to evaluate the roles of proximity and flexibility on covalent adduct formation.

Other Attributes:

- Must be capable of working independently.

- Ability to work proactively required.

- Must have strong organizational skills.

- Must have a high degree of self-motivation fueled by a fundamental interest in contributing to science in general, and drug discovery in particular.

Celgene is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status.

Celgene complies with all applicable national, state and local laws governing nondiscrimination in employment as well as employment eligibility verification requirements of the Immigration and Nationality Act. All applicants must have authorization to work for Celgene in the U.S.

Employment applicants requiring immigration sponsorship must disclose, when initial application for employment is made, whether or not they are legally authorized to work in the U.S. and, if so, whether that authorization permits them to work in the job they seek. In no case should Celgene support of a potential employee’s temporary visa application be construed to guarantee success of that application or amend or otherwise invalidate the "at-will" employment relationship between the employee and Celgene.

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