A postdoctoral position is available in the Stem Cell Biology Group in the National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, North Carolina, to investigate the molecular basis of embryonic stem cell self-renewal and differentiation. We are part of the Laboratory (i.e., department) of Molecular Carcinogenesis (LMC) in NIEHS. We have previously identified a list of novel candidate genes that are important for ES cell self-renewal in a large-scale RNAi screen, and we currently investigating their function in ES cells, somatic cell reprogramming, and mouse development. Our studies so far have uncovered several novel mechanisms in the regulation of self-renewal and pluripotency, and we will continue to pursue those directions. In addition, we have generated microRNA-based shRNA vectors and genome-wide shRNA libraries for gene silencing. We have also developed a multiplex method for high-throughput screening using shRNA libraries. We will carry out RNAi screens to identify genes that are important for lineage specification in ESCs in the future.

Applicants must have a doctoral level degree with less than five years of postdoctoral research. Experience in embryonic stem cells and mouse embryology is highly recommended. Competitive stipends are determined by educational degree(s) and number of years of relevant postdoctoral experience.

NIEHS is surrounded by prominent research institutions, and it provides a stimulating environment and excellent opportunities for young scientists to develop their research careers. The Scientist consistently lists NIEHS among the top places for postdoctoral training. NIH is dedicated to building a diverse community in its training and employment programs.

To apply, send CV and names of references to:
Dr. Guang Hu
Stem Cell Biology Group
Laboratory of Molecular Carcinogenesis
National Institute of Environmental Health and Sciences
Mail Drop D4-03
111 Alexander Drive
Research Triangle Park, NC 27709
E-mail: hug4@niehs.nih.gov

The National Institute of Environmental Health Sciences (NIEHS) is located in Research Triangle Park, North Carolina….

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