Post-doctoral Training Fellow - Evolutionary Genomics and Modelling : Sutton, Surrey, United Kingdom

Job Title: Post-doctoral Training Fellow – Evolutionary Genomics and Modelling

Closing Date of vacancy: 18 April 2014

Division: Molecular Pathology

Team:

Type of Contract: Fixed Term

Length of Contract: 3 years

Salary Range: £28,425 – £40,628 p.a. (full salary scale)

Work Location: Sutton (Surrey)

Hours per week: 35

The Institute of Cancer Research (ICR) is one of the world’s most influential cancer research institutes. Our mission is to make the discoveries that defeat cancer. We have a long and distinguished history of research with a major impact on the outcome for cancer patients. Our unique partnership with The Royal Marsden NHS Foundation Trust (RMH) makes us the largest comprehensive cancer centre in Europe, performing high quality original basic research and translational studies. Under the leadership of Chief Executive Professor Alan Ashworth FRS, we are committed to attracting, developing and retaining the best minds in the world. The ICR was ranked as the UK’s top academic research centre in the 2008 Higher Education Funding Council Research Assessment Exercise. Based on our publication record, citations and impact we rank among the world’s leading cancer research centres.

The Evolutionary Genomics and Modelling group within the Centre for Evolution and Cancer at the Institute of Cancer Research is a multi-disciplinary team that combines cancer genomics with mathematical modelling to understand how tumours evolve, metastasize and develop treatment resistance. We are seeking a highly motivated Postdoctoral Training Fellow with expertise in cancer genomics and bioinformatics to analyse and interpret molecular data from human malignancies. In our lab we profile samples using a variety of genomic techniques, such as whole-exome and targeted ultra-deep sequencing, copy number and gene expression profiling, and bisulfite sequencing. The successful candidate will design new tumour sampling methods and interpret the resulting data in light of tumour evolution, to understand fundamental underlying dynamics of cancer progression and dissemination. The candidate will have the opportunity to interact within a heterogeneous environment of biologists, clinicians, computer scientists and mathematicians, within the Centre for Evolution and Cancer at the ICR.

The responsibilities include designing novel tumour sampling methods, analysing genomic data from tumour samples profiled with next-generation sequencing, SNP/methylation/expression arrays and bisulfite sequencing, and interpretation of the results. The successful candidate will work closely with a diverse team to formulate hypotheses and validate predictions using quantitative genomic assays.

Applicants should have a good first degree in mathematics, statistics or similar and a PhD in bioinformatics, biostatistics or similar. Applicants should have experience with next-generation sequencing and high-throughput microarray data analysis and have a good publication record in the field of cancer genomics. Experience in designing and implementing statistical models for genomic data analysis is highly desirable. Familiarity with large-scale genomic data (e.g. TCGA) would also be advantageous. Excellent organizational and communication skills are essential.

The position is offered on a fixed term 3 year contract in the first instance with a full salary range from £28,425 – £40,628 p.a. inclusive. Starting salary will be based on previous experience.

Informal enquiries can be made to Dr Andrea Sottoriva (andrea.sottoriva@icr.ac.uk). Please DO NOT send your application to Dr. Sottoriva, formal applications must be submitted online.

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