亚洲无码午夜福利视频|日韩国产高清一区二区|欧美老熟妇XB水多毛多|狠狠色成人一区二区三区|在线观看国产精品露脸网站|在线观看一区二区三区视频|激情性无码视频在线观看动漫|99国产精品久久久久久久成人

您的位置:中國(guó)博士人才網(wǎng) > 博士后招收 > 海外博士后招收 > 荷蘭Sanquin研究中心招收博后

關(guān)注微信

荷蘭Sanquin研究中心招收博后

時(shí)間:2014-08-26來(lái)源:中國(guó)博士人才網(wǎng) 作者:91boshi

Hemolytic anemia is characterized by a shortened survival of red blood cells (RBCs). A large number of diseases are characterized and/or accompanied by hemolysis, including sickle cell disease, autoimmune hemolytic anemia and hemolytic transfusion reactions, paroxysmal nocturnal hemoglobinuria, malaria or microangiopathic hemolytic anemia (e.g. thrombotic thrombocytopenic purpura (TTP), sepsis). Regardless the cause, intravascular destruction results in the release of the intracellular contents of RBCs characterized by clinical symptoms, such as fever, hypotension, disseminated intravascular coagulation (DIC) and organ dysfunction (e.g renal failure). Recent insights show that the destruction of RBC in the circulation culminates in the release of highly effective pro-inflammatory mediators, including hemoglobin, heme and iron. Heme itself is highly cytotoxic by interfering with cellular membranes. The pro-inflammatory effects of these mediators released during hemolysis significantly contribute to morbidity and mortality of hemolytic diseases. Plasma proteins are crucially involved to prevent the deleterious effects of free iron and heme, respectively. Haptoglobin, an Alpha-2-glycoprotein can bind free hemoglobin with a high affinity forming a stable complex, which is efficiently removed via CD163 on macrophages in the liver. Hemopexin (Hpx), a plasma protein with an extremely high binding affinity to heme, forms complexes with heme which are subsequently removed from the circulation via CD91 expressed on macrophages. Although being positive acute phase proteins, both, haptoglobin and Hpx are rapidly consumed due to complex formation with their targets. As a result free hemoglobin and heme can exert their detrimental effects. Therapeutic administration of haptoglobin and Hpx in these clinical situations could potentially limit the detrimental effects of free hemoglobin and heme. The aim of this project is to produce functional Hpx and haptoglobin from plasma and from waste fractions (fraction IV) from Cohn fractionation. Cellular in-vitro tests will be set up in order to test the efficacy of purified Hpx and haptoglobin to neutralize the toxic effects of hemoglobin, heme and iron. The purified functional proteins Hpx and haptoglobin can be used in the future as therapeutic protein in animal models and patients suffering from hemolytic anemia. Unit: The group of Dr. Sacha Zeerleder, which makes part of the department of Immunopathology, is dedicated to study the pathogenesis of inflammation induced by damage-associated molecular pattern (DAMPs), eg. cell-free DNA, histones or heme. The main interest focuses on the specific effects of the various DAMPs in the pathogenesis of inflammation, on the mechanism and regulation of DAMP release and how the detrimental effects of circulating DAMPs can be neutralized efficiently in order to develop therapeutics to improve morbidity and mortality of inflammatory disease. 

Description

Candidates should have an academic background with profound experience in protein biochemistry and purification techniques as well as in cellular biology. We look for an independent candidate with a collaborative nature, a strong affinity for multidisciplinary research and the capacity to write and communicate fluently in English.

Benefits

salary and conditions are conform CAO Sanquin; a 36-hour-week; reimbursement of travel expenses; a temporary appointment for a period of 3 years; working hours are fixed by mutual agreement; 8,33% year-end; by full-time employment 201 vacation hours.

為防止簡(jiǎn)歷投遞丟失請(qǐng)抄送一份至:boshijob@126.com(郵件標(biāo)題格式:應(yīng)聘職位名稱+姓名+學(xué)歷+專業(yè)+中國(guó)博士人才網(wǎng))

中國(guó)-博士人才網(wǎng)發(fā)布

聲明提示:凡本網(wǎng)注明“來(lái)源:XXX”的文/圖等稿件,本網(wǎng)轉(zhuǎn)載出于傳遞更多信息及方便產(chǎn)業(yè)探討之目的,并不意味著本站贊同其觀點(diǎn)或證實(shí)其內(nèi)容的真實(shí)性,文章內(nèi)容僅供參考。

相關(guān)文章