Postdoctoral position in MS-based proteomics

 
Employer:  University of Copenhagen  

Date Posted:  10/06/2014  
Application Deadline: 10/31/2014 

 
Job Description

One postdoctoral stipend is available in the Proteomics Technology Development & Application group at The Novo Nordisk Foundation Center for Protein Research (CPR – www.cpr.ku.dk). The Center has been established at the Faculty of Health and Medical Sciences, University of Copenhagen, to promote basic and applied discovery research on human proteins of medical relevance. The Center comprises a wide range of expertise and resources including proteomics, protein production and characterization to disease mechanisms. The proteomics section is headed by Prof. Dr. Matthias Mann, and the “Proteomics Technology Development & Application” group is lead by Group Leader Dr. Michael L. Nielsen. By joining our team, you will be part of a young and dynamic team consisting of international researchers. The Nielsen group focuses on developing novel proteomics methods & technologies for studying the cellular outcomes at a ‘systems-level’, with the aim to understand cellular phenotypes and diseases. To this end, we employ cutting-edge mass spectrometry (MS)-based technologies for developing unbiased proteomics methods for identification and quantification of post-translational modifications (PTMs), such as ubiquitylation, arginine methylation and ADP-ribosylation (Danielsen et al, MCP, 2011; Sylvestersen et al, COCB, 2013; Sylvestersen et al, MCP, 2014; Jungmichel et al, Mol Cell, 2013) and other cellular signalling molecules like phophoinositides (Jungmichel et al, Cell Reports, 2014).

For more information about the research group please visit:
http://www.cpr.ku.dk/research/proteomics/proteomics-technology-development--application/

If you still have questions, contact us: jobs@cpr.ku.dk.

Project Description
Recently, we have improved mass spectrometry-based proteomics methods for unbiased analysis of various post-translational modifications (Jungmichel et al, Mol Cell., 2013; Sylvestersen et al, MCP, 2014; Tessarz et al, Nature, 2014; Christophorou et al, Nature, 2014). The applicant is expected to use cutting-edge proteomic technology for characterization of post-translational modifications in mammalian cell systems, and to perform biological follow-up experiments on novel and interesting findings derived from these proteomic screens. However, candidates interested in developing novel proteomic technologies are also encouraged to apply. The ideal candidate should be able to conduct independent and creative research, demonstrate scientific productivity, and show good inter-personal and communication skills.

Projected start date: Fall 2014/Spring 2015 or later.

Qualifications

The candidate is required to have PhD or equivalent degree in natural or medical science.
Excellent scientific track record, including at least one publication as first author in a high quality, peer reviewed international journal.
Prior experience in research fields related to post-translational modifications, such as poly-ADP-ribosylation, arginine methylation, or othes would be considered a distinct advantage.
Prior experience in high resolution mass spectrometry is not essential, but would be considered an advantage.
Good communication skills, both oral and written.
An analytical aptitude for devising innovative scientific or technical solutions.
Demonstrate enthusiasm, motivation, flexibility and confidence.

Place of employment and work
The employment is at CPR (www.cpr.ku.dk), University of Copenhagen, located in central Copenhagen. The research environment at CPR is vibrant, ambitious, and international, with approx. 30 different nationalities currently represented. The Center comprises modern laboratories and state-of-the-art facilities within protein science. Seminars with high-profile international speakers and regular internal research seminars are organized at the Center.

Terms of salary and employment
Salary, pension and terms of employment will be in accordance with the agreement between the Ministry of Finance and The Academics Central organization. Currently, the monthly salary is around 31,800 – 33,500 DKK (around 4,250€) plus 17.1 % in pension contribution.

Application
Your application should be submitted electronically to the link below in this advertisement:

or through: http://ssl1.peoplexs.com/Peoplexs22/CandidatesPortalNoLogin/ApplicationForm.cfm?PortalID=12921&VacatureID=691308

Your application should include the following documents:

Motivated letter of application
Curriculum vitae, incl. education and experience
List of publications
Letters of recommendation
Names and contact details for two referees
For further information about the position, please contact Group Leader Michael Lund Nielsen Michael.lund.nielsen@cpr.ku.dk

Deadline for application: 31 October 2014  
 
   
  
Contact:  Michael Lund Nielsen 
Proteomics Technology Development & Application group at The Novo Nordisk Foundation Center for Protein Research
University of Copenhagen
Copenhagen,  2200
Denmark  
Online Application: Apply for this job from Employer's website 
 
 基于MS的蛋白質(zhì)組學(xué)博士后

 
雇主：哥本哈根大學(xué) 

發(fā)布日期：2014年10月6日 
報名截止日期：2014年10月31日

 
職位描述

一個博士后津貼是蛋白質(zhì)組學(xué)技術(shù)開發(fā)與應(yīng)用組的諾和諾德基金會中心蛋白質(zhì)研究可用（CPR - www.cpr.ku.dk）。該中心成立至今，在衛(wèi)生和醫(yī)學(xué)科學(xué)，哥本哈根大學(xué)的學(xué)院，以促進(jìn)醫(yī)療相關(guān)的人體蛋白質(zhì)的基礎(chǔ)和應(yīng)用開發(fā)研究。該中心包括一個廣泛的專業(yè)知識和資源，包括蛋白質(zhì)組學(xué)，蛋白質(zhì)的生產(chǎn)和表征疾病的機(jī)制。蛋白質(zhì)組學(xué)部分由教授馬蒂亞斯·曼恩博士為首，而“蛋白質(zhì)組學(xué)技術(shù)開發(fā)與應(yīng)用”組中的主角由組長博士邁克爾·L.尼爾森。加入我們的團(tuán)隊(duì)，你將是一個年輕而充滿活力的團(tuán)隊(duì)組成的國際研究的一部分。尼爾森集團(tuán)專注于開發(fā)新的蛋白組學(xué)方法與技術(shù)研究細(xì)胞的成果，在一個“系統(tǒng)級”，目的是了解細(xì)胞表型和疾病。為此，我們采用尖端的質(zhì)譜（MS）為基礎(chǔ)的技術(shù)的發(fā)展不偏不倚蛋白質(zhì)組學(xué)方法鑒定的翻譯后修飾（翻譯后修飾），如泛素，精氨酸甲基化和ADP-核糖基化（丹尼爾森等和量化， MCP，2011; Sylvestersen等，COCB，2013; Sylvestersen等，MCP，2014年; Jungmichel等，分子細(xì)胞，2013年）和其他細(xì)胞信號分子如phophoinositides（Jungmichel等，細(xì)胞報道，2014年）。

有關(guān)調(diào)研組的更多信息，請?jiān)L問： 
http://www.cpr.ku.dk/research/proteomics/proteomics技術(shù)開發(fā) - application/

如果您還有疑問，請聯(lián)系我們：jobs@cpr.ku.dk。

項(xiàng)目簡介 
最近，我們又提高了質(zhì)譜為基礎(chǔ)的蛋白質(zhì)組學(xué)方法對各種翻譯后修飾公正的分析（Jungmichel等，分子細(xì)胞，2013; Sylvestersen等，MCP，2014年; Tessarz等，Nature，2014年; Christophorou等自然，2014年）。申請人預(yù)計(jì)使用尖端的蛋白質(zhì)組學(xué)技術(shù)用于在哺乳動物細(xì)胞系統(tǒng)中的翻譯后修飾的表征，并且對從這些蛋白質(zhì)的屏幕衍生的新的和有趣的發(fā)現(xiàn)執(zhí)行生物后續(xù)實(shí)驗(yàn)。但是，我們也鼓勵有興趣發(fā)展的新技術(shù)，蛋白質(zhì)組學(xué)候選人申請。理想的候選人應(yīng)該能夠進(jìn)行獨(dú)立和創(chuàng)造性的研究，展示了科學(xué)的生產(chǎn)效率，并表現(xiàn)出良好的人際關(guān)系和溝通技巧。

預(yù)計(jì)開始日期：2014年秋季/春季2015年或以后。

資格

應(yīng)聘者須具有博士學(xué)位或同等學(xué)歷，在自然或醫(yī)學(xué)。 
優(yōu)秀的研發(fā)背景，包括至少一個出版物作為第一作者的一種高品質(zhì)，同行評審國際期刊。 
在與翻譯后修飾研究領(lǐng)域，如聚ADP-核糖基化，甲基化精氨酸，或othes以前的經(jīng)驗(yàn)將被視為一個明顯的優(yōu)勢。 
在高分辨質(zhì)譜現(xiàn)有經(jīng)驗(yàn)不是必需的，但是將被認(rèn)為是一個優(yōu)點(diǎn)。 
良好的溝通能力，口頭和書面。 
一個分析能力傾向，以便制訂創(chuàng)新的科學(xué)或技術(shù)解決方案。 
展現(xiàn)熱情，積極性，靈活性和信心。

就業(yè)和工作場所 
就業(yè)是心肺復(fù)蘇術(shù)（www.cpr.ku.dk），哥本哈根大學(xué)，位于哥本哈根市中心。在心肺復(fù)蘇的研究環(huán)境是充滿活力的，有事業(yè)心，以及國際，與約目前，代表30個不同的國籍。該中心包括蛋白質(zhì)科學(xué)中的現(xiàn)代化的實(shí)驗(yàn)室和國家的最先進(jìn)的設(shè)施。研討會與高知名度的國際演講者和定期的內(nèi)部研究討論會的組織為中心。

條款的工資和就業(yè) 
工資，養(yǎng)老金和就業(yè)方面將按照財(cái)政部和學(xué)者中央組織之間的協(xié)議。目前，月薪約31,800 - 33,500丹麥克朗（約4,250€）的撫恤金，另加貢獻(xiàn)17.1％。

應(yīng)用 
您的應(yīng)用程序應(yīng)以電子提交下面這則廣告的鏈接：

或者通過： http://ssl1.peoplexs.com/Peoplexs22/CandidatesPortalNoLogin/ApplicationForm.cfm?PortalID=12921&VacatureID=691308

您的應(yīng)用程序應(yīng)該包括下列文件：

申請動機(jī)信 
履歷，包括教育和經(jīng)驗(yàn) 
出版物清單 
推薦信 
姓名和聯(lián)系方式，有兩個裁判 
有關(guān)位置的詳細(xì)信息，請聯(lián)系集團(tuán)負(fù)責(zé)人邁克爾·隆德尼爾森Michael.lund.nielsen@cpr.ku.dk

申請截止日期：2014年10月31日 
 
   
  
聯(lián)系方式：邁克爾·尼爾森隆德 
蛋白質(zhì)組學(xué)技術(shù)開發(fā)與應(yīng)用組的諾和諾德基金會中心蛋白質(zhì)研究 
哥本哈根大學(xué) 
哥本哈根，2200 
丹麥 

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