A postdoctoral position is available for studies on the structure-function, molecular genetics, and biological/pharmacological properties of the proton-coupled folate transporter (PCFT) cloned by this laboratory (Cell 127:917-928, 2006). Loss-of-function mutations in his transporter are the molecular basis of hereditary folate malabsorption. PCFT mediates intestinal folate absorption, folate transport across the choroid plexus and transport of antifolates into tumor cells within their acidic microenvironment. Candidates should have a strong background in molecular biology and/or physiology/electrophysiology/ homology modeling and a track-record of productivity during their doctoral training. This is a participating laboratory in the Experimental Therapeutics Program of the NCI-designated Albert Einstein Cancer Center
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