Postdoctoral Fellow - Investigation of Intestinal Epithelial Integrity with Organoid Cultures : Worcester, MA, United States

DESCRIPTION/RESPONSIBILITIES:
2015 will be the year of the AbbVie Postdoctoral Program launch. We are looking for the incoming class to join AbbVie as the company is positioning itself for another significant year of growth and of the continuing advancement of its patient-driven science and its strategic priorities. In a collaborative, resource rich environment, you and your scientific mentor will be exploring, targeting, investigating and evaluating key areas of novel research with a publication as the end point. We have an exceptional postdoctoral opportunity within our Foundational Immunology Group reporting into a Principal Scientist studying mucosal immunology at the AbbVie Bioresearch Center (ABC) based in Worcester, Massachusetts.

ABC is a fully integrated biologics research and development and commercial manufacturing site with activities spanning the discovery, development, commercial launch and product life cycle management of the AbbVie biologics pipeline. The Foundational Immunology Group is seeking a motivated and innovative applicant to the postdoctoral program to investigate mechanisms of intestinal epithelial cell function using human intestinal organoids. This research program is critical to the broader Immunology strategy and is expected to deliver new insights into biology relevant to inflammatory bowel disease (IBD) and assist with identification and validation of drug discovery programs that will form the basis of next generation therapeutics for IBD.

Key responsibilities include:

· Establish 3-D and 2-D human intestinal organoid culture systems

· Develop methodology to study specific epithelial cell functions (i.e. tight junction formation, mucus production, defensin production, barrier function)

· Investigate candidate epithelial biomarkers associated with human IBD

· Establish coculture conditions with myofibroblasts to study their influence on organoid behavior

· Establish protocols for genetic modification of organoids by retroviral overexpression/knockdown or withCRISPR technology to understand the effect such modifications have on organoid growth, differentiation, survival, and function

· Develop wound assays to explore processes involved with healing

REQUIRED SKILLS:
Basic:

• PhD in Immunology, Molecular or Cellular Biology, or a related discipline from an accredited and nationally ranked university
• Background in epithelial cell biology and organoid culture development
• Experience with immune cell biology and primary culture of immune cells
• Excellent in vitro and molecular biology skills
• Familiarity with the pathophysiology of IBD
• Authorized to work in the U.S.
• Provide a narrative on why your academic training would qualify you for this position and why you have a sustained interest in this program
• Provide three letters of recommendation, one at least from your PI, and preferably, one from a member of your thesis committee
• Record of publication in a well-recognized journal(s)

Preferred:

• Experience with mammalian cell signaling research
• Experience with myofibroblast biology and culturingExperience with genetic manipulation of organoid
• Ability to effectively work both independently and collaboratively
• Excellent problem-solving, communication, and project management skills

Key AbbVie Competencies:

• Builds strong relationships with peers and cross functionally with partners outside of the team to enable higher performance.
• Learns fast, grasps the ?essence? and can change the course quickly where indicated.
• Raises the bar and is never satisfied with the status quo.
• Creates a learning environment, open to suggestions and experimentation for improvement.
• Embraces the ideas of others, nurtures innovation and manages innovation to reality.

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