Post-Doctoral Research Fellow : Boston, MA, United States
Our team, led by Dr. Ramnik Xavier, aim to understand the determinants of mucosal tolerance and immunity. To this end, our lab is using a combination of physiologically relevant cell-based assays, genome editing, novel mouse models, and computational analyses.
We are looking for postdoctoral associates to identify the components of the innate and adaptive immune systems that interact dynamically in human health and disease. Recent studies in our group have uncovered a novel role for CLEC12A as an early adaptor molecule in antibacterial autophagy (PMID: 26095365); used a CARD9 rare variant, that confers protection against inflammation, to uncover a TRIM62-mediated mechanism for regulation of CARD9 activation (PMID: 26488816); and identified DYRK1A as a physiologically relevant regulator of regulatory T cell differentiation (PMID: 25998054).
Current projects include (1) generate novel mouse models using cutting edge technologies, such asCRISPR, to uncover mechanisms of pathogenesis by inducing inflammation using infectious, non-infectious, and immune cell transfer models; (2) perform functional genomic screens to place disease-associated genetic variants in pathways; (3) examine the interactions between host genetics and the microbiome during inflammation; and (4) determine the role of novel autophagy genes in antibacterial defenses in vivo, as well as characterizing cell-specific functions of those genes.
Requirements
• Ph.D. or M.D./Ph.D. in immunology, cell biology or molecular biology
• Maximum 0-2 years of related postdoc experience preferred
• Well versed in the application of mouse models
• Strong publication record in high-impact journals
• Excellent communication skills and the ability
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