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美國明尼蘇達大學招收博后

時間:2015-12-30來源:未知 作者:91boshi

Postdoctoral Position in metabolic biology, microRNA, and liver cancer

 

Job Description

 

One postdoctoral scholar and one junior scientist position are available immediately in the Division of Gastroenterology, Hepatology and Nutrition of the Department of Medicine at the University of Minnesota, Twin Cities. 

Required/Preferred Qualifications:
Ph.D. required, or M.D. 
More than three years of post-graduate research experience in the fields of liver cancer, metabolic diseases, microRNA, and RNA drug delivery.
Skills in molecular biology, cellular biology, bioinformatics, and mouse models required, which includes DNA and RNA isolation, western blot, northern blot, southern blot, real-time RT-PCR, luciferase assay, florescence microscopy, immunostaining, mouse mating, small animal surgery, hepatocyte isolation, stem cell differentiation, primer design etc. 

Lab situation

The lab is well-funded and has a strong publication record. The competitive salary will be provided for qualified candidates. The potential candidates will be involved in both basic and translational research, which will significantly benefit the career development of the potential candidates. 
The University of Minnesota Twin Cities has campuses in Minneapolis and St. 
Paul, a metropolitan area known as a top place to visit, work, and live (http://www.minneapolis.org/media/facts-amp-research/accolades). The University of Minnesota is considered a Public Ivy. It ranked 22nd by Academic Ranking of World Universities in 2015. U.S. News & World Report’s recent rankings placed the University as the 29th Best Global University and the Medical School 10th. 

Duties/Responsibilities 
Responsibilities include participating in the design, implementation and evaluation of collaborative research studies; analyzing and interpreting data; creating publication quality figures summarizing data; assisting with manuscript and grant preparation; maintaining a legible and self-explanatory scientific notebook, and presenting results during lab meetings and at appropriate scientific conferences. Above all, your major duties will be to conduct bench research as deemed necessary and appropriate by PI and to assist and/or collaborate with other research staff on scientific pursuits of mutual interests.
She will be responsible primarily for the proposed animal experiments, including animal surgery, administration of drugs, blood and tissue sampling and their processing and data acquisition. She will also be responsible for conducting vector cloning, gene expression analysis, cell culture, tissue processing, histology, image acquisition, record keeping, data acquisition, analyses, presentations, and publications.
Project:

1.The objective of this R01 is to determine the roles of the crosstalk of miR-378/378* with NRF, SORT1 and TNFα in regulating hepatic lipid accumulation and the progression of NAFLD to NASH. The long-term goal is to develop miR-378 anti-sense oligonucleotide as a therapeutic target for NAFLD and NASH. 

2. Preclinical trial of miR-24 for the treatment of hyperglycemia and NAFDL
3. Preclinical trial of miR-26 for the treatment of NAFLD and liver cancer. 

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