Job Description
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The Research Centre on Aging is opening a new $45,000 postdoctoral fellowship to support its researchers in the Biological Mechanisms of Aging (BMA) axis in developing their MiniBrain project. This one-year fellowship will give the postdoctoral fellow time to apply for the regular funding competitions held by national granting agencies for the year following the fellowship. The fellowship award will be based on the excellence of the application as evaluated by peers. The MiniBrain Project: The production of beta-amyloid in Alzheimer's disease is the outcome of various simultaneous or successive insults to the brain. Consequently, identifying the origin of these insults would make it possible to target them with appropriate interventions. Our objective is to build a three-dimensional (3-D) "mini-brain" in a bioreactor that would enable us to simulate these factors singly or in combination so as to elucidate the causes of beta-amyloid production. Primary cell cultures of human neurons, microglia, and astrocytes—with or without immune cells—are performed with various constraints (immune, metabolic, oxidative, and/or infectious). Beta-amyloid production will be studied. Once the factors affecting beta-amyloid production have been identified, we will study the pathways leading to it. Elucidating the molecular pathways leading to beta-amyloid production will serve as the basis for determining the therapeutic target in treating Alzheimer's disease. Required Documents: - Duly completed CdRV grant application form - Letter of motivation - Canadian Common CV or simplified CV form - Official doctorate and master's degree transcripts - Proof of grant or scholarship awards for the last three years - Notices of articles submitted for publication and editor's notices of articles accepted for publication |
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