·         University of Illinois at Chicago

　　·         Location: Chicago, IL

　　·         Job Number: 7052992

　　·         Posting Date: Sep 10, 2018

　　Job Description

　　The Division of Surgical Oncology (Department of Surgery) at the University of Illinois at Chicago is seeking to fill a Postdoctoral Research Associate position for a funded project to study the signaling pathways that regulate various cellular events in cancer progression. The main focus of research will be to elucidate in-depth the mechanism of cancer cell resistance to apoptosis, identify potential targets and design strategies to ameliorate resistance. The laboratory is equipped with state-of-the art equipments and employs the latest molecular, biochemical and cell biological approaches in cell culture and animal models of cancer. The Institution offers a highly interactive cancer research environment and access to top-of the line animal care and other core facilities.

　　Applicants must have a recent Ph.D. degree with relevant publications in the field of biochemistry, molecular or cellular biology. Candidates should have demonstrated skills in western blotting, co-immunoprecipitation, PCR, qPCR, gene arrays, cell culture, transfection, gene cloning, IHC and in various in vivo xenograft and metastasis cancer models. Experience with hepatocellular carcinoma research will be an added plus. Ability to work in a competitive environment, strong communication skills in English, demonstrated creativity & independence, and high motivation are strongly anticipated.

　　Selected Publications:

　　1. Ke R, Vishnoi K, Viswakarma N, Santha S, Das S, Rana A and Rana B. Involvement of AMP-activated protein kinase and Death Receptor 5 in TRAIL-Berberine-induced apoptosis of cancer cells. Sci. Rep. 2018; 8, 5521.

　　2. Santha S, Davaakhuu G, Basu A, Ke R, Das S, Rana A and Rana B. Modulation of Glycogen Synthase Kinase-3β following TRAIL combinatorial treatment in cancer cells. Oncotarget. 2016; 7(41):66892-66905.

　　3. Santha S, Viswakarma N, Das S, Rana A and Rana B. TRAIL-Troglitazone-induced apoptosis in prostate Cancer Cells involve AMP-activated protein kinase. J. Biol. Chem. 2015; 290, 21865-75.

　　4. Senthivinayagam S, Mishra P, Paramasivam SK, Yallapragada S, Chatterjee M, Wong L, Rana A, and Rana B. Caspase mediated cleavage of b-catenin precedes drug induced apoptosis in resistant cancer cells. J. Biol. Chem. 2009; 284, 13577-88.

　　5. Thylur RP, Senthivinayagam S, Campbell EM, Rangasamy V, Thorenoor N, Sondarva G, Mehrotra S, Mishra P, Zook E, Le PT, Rana A and Rana B. Mixed Lineage Kinase 3 modulates b-catenin signaling in cancer cells. J. Biol. Chem. 2011; 286, 37470-82.

　　6. Mishra P, Senthivinayagam S, Rangasamy V, Sondarva G and Rana B. Mixed lineage Kinase-3/JNK1 axis promotes migration of human gastric cancer cells following gastrin stimulation. Mol. Endocrinol. 2010; 24, 598-607.

　　Interested candidates, please send curriculum vitae and the names of three references to:

　　Basabi Rana, Ph.D.

　　Professor

　　Department of Surgery, (Division of Surgical Oncology)

　　University of Illinois at Chicago

　　840 S. Wood Street, Clinical Sciences Building - MC 958

　　Chicago, IL 60612

　　Email: basrana@uic.edu

　　Fax: 312-996-9365

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