An experimental (“wet-lab”) postdoctoral position in gene regulation and functional genomics is available in Dr. Haiyuan Yu’s group at Cornell University. Dr. Yu’s group works closely with Dr. John Lis’s group with weekly joint group meetings. Drs Yu and Lis jointly advise PhD students and postdocs, and are co-PIs for a newly-established functional characterization center within the ENCODE consortium. We are looking for motivated post-doctoral researchers to develop innovative functional genomic technologies to understand the fundamental architecture of transcriptional regulatory elements (enhancers and promoters), the impact of noncoding mutations on gene regulation, and how gene regulation changes genome wide under various disease conditions. Specifically, we will build upon the technologies that we have developed/implemented here across the two groups, such as Clone-seq, eSTARR-seq, and PRO-seq.

　　The ideal candidate should have a strong track record and extensive lab experience in molecular biology, biochemistry, cell biology, and/or genetics. Experience with next-generation sequencing techniques is strongly preferred. Experience in network biology or systems biology is not required. The starting date is flexible and can be as early as December 2018. Applications will be accepted until the position is filled. Competitive salary commensurate with experience and skills, as well as a generous benefits package will be offered. Interested applicants should send a PDF with CV, a brief description of future research interests (optional), and contact information for three references to Dr. Haiyuan Yu (haiyuan.yu@cornell.edu). Please include “Genomics Postdoc 2018” in the subject line. Informal inquiries are welcome.

　　Selected Publications:

　　An interactome perturbation framework prioritizes damaging missense mutations for developmental disorders, Nature Genetics, 2018

　　A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human, Cell, 2016.

　　A Massively Parallel Pipeline to Clone DNA Variants and Examine Molecular Phenotypes of Human Disease Mutations, PLoS Genetics, 2014.

　　Integrative annotation of variants from 1,092 humans: application to cancer genomics, _Science*_, 2013.

　　Three-dimensional reconstruction of protein networks provides insight into human genetic disease, Nature Biotechnology, 2012.

　　Cornell University is an innovative Ivy League university and a great place to work. Our inclusive community of scholars, students and staff impart an uncommon sense of larger purpose and contribute creative ideas to further the university's mission of teaching, discovery and engagement. With our main campus located in Ithaca, NY Cornell's far-flung global presence includes the medical college's campuses in Manhattan and Doha, Qatar, as well as the new Cornell Tech campus located on Roosevelt Island in the heart of New York City.

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