St. Jude Children’s Research Hospital is a world-renowned institution that is recognized as one of the best places to work in the nation. As a premier center for research and treatment of childhood catastrophic diseases, we employ a diverse team of scientific and healthcare professionals dedicated to the promise of hope. Children from all 50 states and from around the world have come through the doors of St. Jude for treatment, and thousands more have benefited from our research.

　　BCL-2 family members are well recognized regulators of programmed cell death and are responsible for regulating the homeostasis of tissues and defects in this pathway contribute to a variety of human diseases. Myeloid cell leukemia sequence 1 (MCL-1) is a unique anti-apoptotic molecule as its expression is highly regulated and it plays critical roles in promoting the survival of a myriad of cellular lineages. Recently, the Opferman laboratory revealed that in addition to its canonical role in antagonizing cell death that MCL-1 also promotes normal mitochondrial function in cells. These findings provide an attractive model for how both of MCL-1’s diverse functions may contribute to normal cell homeostasis and function. Additionally, MCL-1 is a highly amplified gene in human cancer leading to the possibility that both of these functional aspects may contribute to malignant cell growth and evasion of apoptosis. Therefore, the Opferman laboratory is taking a multidisciplinary approach to dissect mechanistically how these functions of MCL-1 are regulated and to understand how these functional roles of MCL-1 contribute to normal development and oncogenesis.

　　This post-doctoral position is an ideal opportunity for enthusiastic candidates that have recently earned/expect to earn a PhD and/or MD, have experience in cell biology, molecular biology, and biochemical techniques. The strongest candidates will have demonstrated success in conducting original research as evidenced by peer-reviewed publications. Qualified applicants should apply for job 39418 at https://bit.ly/2QqNrwN

　　Contact Information

　　Joseph Opferman, PhD

　　Associate Member, Department of Cell & Molecular Biology

　　St. Jude Children’s Research Hospital

　　262 Danny Thomas Place

　　Memphis, TN 38105

　　joseph.opferman@stjude.org

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