The Leibniz Institute for Natural Product Research and Infection Biology – Hans Knöll Institute – (HKI, www.leibniz-hki.de) investigates the pathobiology of human-pathogenic fungi and identifies targets for the development of novel natural product-based antibiotics. The Department of Infection Biology invites applications for

　　Post Doctoral Researcher (m/f)

　　Successful candidates will investigate the field Complement Evasion of pathogenic microbes including in particular Candida albicans and Aspergillus fumigatus. Main topics of the project are

　　·         Characterisation of fungal immune evasion proteins

　　·         How do microbial immune evasion proteins influence innate and cellular immune response?

　　·         Functional characterization of FHR5 recruitment by pathogenic microbes

　　For further details please see literature below:

　　Requirement: PhD degree in biology, genetics or life sciences. Experience, knowledge and good experimental skills in cell and molecular biology, genetics and biochemistry are of advantage.

　　For further information

　　Prof. Dr. Peter Zipfel | +49 3641 532 1300 | career@leibniz-hki.de

　　Applications

　　Salary is paid according to German TV-L (salary agreement for public service employees). As an equal opportunity employer the HKI is committed to increase the percentage of female scientists and therefore especially encourages them to apply.

　　Complete applications in English should include a letter of interest, curriculum vitae, a complete list of publications, brief statement of research experiences, a list of three potential references, full academic record (copies of degree certificates), and should be submitted by https://jobs.hki-jena.de/jobs/Post-Doctoral-Researcher-mf-de-j178.html? until 15.12.2018.

　　Literature:

　　Meinel C et al. (2017) Streptococcus pneumoniae from HUS patients bind human plasminogen via the surface protein PspC and use plasmin to damage human endothelial cells. J Inf Dis 21, 358-370

　　Zipfel PF, Hallström T, Riesbeck K (2013) Pathogenic microbes – Tipping the balance. Mol Immunol 56, 152-160.

　　Zipfel PF, Skerka C (2009) Complement regulators and inhibitory proteins. Nat Rev Immunol 9, 729-740.

　　Dasari P, Shopova IA, Stroe M, Wartenberg D, Dahse H-M, Beyersdorf N, Hortschansky P, Dietrich S, Cseresnyés Z, Figge MT, Westermann M, Skerka C, Brakhage AA, Zipfel PF (2018) Aspf2 from Aspergillus fumigatus recruits human immune regulators for immune evasion and cell damage. Frontiers in Immunology 9, 1635.

　　Luo S, Dasari P, Reiher N, Hartmann A, Jacksch S, Wende E, Barz D, Niemiec MJ, Jacobsen I, Beyersdorf N, Hünig T, Klos A, Skerka C, Zipfel PF (2018) The secreted Candida albicans protein Pra1 disrupts host defense by broadly targeting and blocking complement C3 and C3 activation fragments. Mol Immunol S0161-5890(17), 30440-30446.

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