Post Doctoral Research Fellow, Stem Cell Biology & Alzheimer's

　　Rush University Medical Center

　　Chicago, IL

　　Job Title: Post Doctoral Research Fellow, Stem Cell Biology & Alzheimer's

　　Department:

　　Shift: 1st

　　Specialty: Research

　　Job Number: 2018-1069

　　Date Posted: 05/04/2018

　　Position Type: Research

　　Job Qualifications:

　　The Rush University Alzheimer's Disease Center (RADC) is a leading experimental and epidemiological center for the study of Alzheimer's disease. Over the past decade, the RADC has carried out numerous community-based cohort studies and generated multi-omic data from human specimens (https://www.radc.rush.edu/). An ongoing effort is to employ a human cell-based culture system to validate AD candidate genes identified from our multi-omic data, and ultimately to bridge the gap between systems biology and drug discovery. As part of this major expansion, we are seeking a highly motivated candidate for a Postdoctoral position in Stem Cell Biology.

　　Position Highlights:

　　Our group has published in Science, Nature and Cell, and we expect that your research will be of similar high impact. To facilitate these results, you will be assisted in utilizing the most clinically detailed and extensive collection of Alzheimer's brain resources in the world. You will be supported by a faculty team of 30 statisticians, neuropathologists, systems and experimental biologists, as well as staff of 100+ who are gathering clinical and experimental detail on Alzheimer's cohorts. Examples of the rich data can be seen here and in many 1000+ citation papers. Additionally, this position offers:

　　Priority on quickly producing high-impact publications, taking advantage of unique Alzheimer's datasets at Rush University.

　　Thousands of post-mortem tissues available for person-specific AD models

　　Deeply phenotyped sample origins, with multiple omics, cognitive testing and neuroimaging

　　Sole access to the latest sequencing and cellular phenotyping equipment

　　Pursue highly novel targets and follow effects wherever they lead

　　Scientific focus in a flat organizational structure, with stable funding

　　Career development and grant-writing opportunities alongside highly successful scientists

　　Position Responsibilities:

　　Lead and perform range of lab-based experiments including reprogramming human somatic cells into induced pluripotent stem cells, stem cell banking and validations, stem cell differentiation into disease-relevant cell types, generating 2D and 3D culture models, phenotyping diseased cells with cellular, molecular and functional assays.

　　Oversee the day to day organization of different components of the projects.

　　Work collaboratively with other RADC teams who are working on related research questions.

　　Position Qualifications Include:

　　Ph.D. or MD or equivalent degree in the field of Neuroscience, Cell biology, Developmental biology, Stem cell biology or Molecular biology or a related Field

　　Excellent skills and experience in human iPSC derivation, stem cell culture and differentiation, 2D and organoid 3D culture

　　Excellent skills and experience in cellular and molecular biology and fluorescence imaging

　　Experience in calcium imaging, multielectrode array are highly desirable

　　Experience in genome editing and next gene sequencing is a plus

　　Excellent analytic and problem-solving skills

　　Excellent project planning and organization skills

　　Excellent written and oral communication skills

　　Proven ability to work independently and in collaborative team environments

　　Company Highlights:

　　Ranked among the top academic medical centers in the country, Rush University Medical Center is an outstanding place to enhance your career. Everything we do centers on one goal: improving patient care.

　　Rush's 14-story hospital Tower is the cornerstone of the Rush Transformation, and is the symbol of a philosophy-an evolution in the delivery of patient-centered care.

　　Rush offers a competitive salary, valuable healthy living benefits to include: health, dental and vision to help you maintain and improve your health. Rush also offers several ways to invest in your future. Whether you're saving for retirement or a child's education, Rush offers benefits to help you make the most of your moneynow and in the future.

　　Rush is an equal opportunity employer. We evaluate qualified applicants without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, veteran status, and other legally protected characteristics.

　　The Rush University Alzheimer's Disease Center (RADC) is a leading experimental and epidemiological center for the study of Alzheimer's disease. Over the past decade, the RADC has carried out numerous community-based cohort studies and generated multi-omic data from human specimens (https://www.radc.rush.edu/). An ongoing effort is to employ a human cell-based culture system to validate AD candidate genes identified from our multi-omic data, and ultimately to bridge the gap between systems biology and drug discovery. As part of this major expansion, we are seeking a highly motivated candidate for a Postdoctoral position in Stem Cell Biology.

　　Position Highlights:

　　Our group has published in Science, Nature and Cell, and we expect that your research will be of similar high impact. To facilitate these results, you will be assisted in utilizing the most clinically detailed and extensive collection of Alzheimer's brain resources in the world. You will be supported by a faculty team of 30 statisticians, neuropathologists, systems and experimental biologists, as well as staff of 100+ who are gathering clinical and experimental detail on Alzheimer's cohorts. Examples of the rich data can be seen here and in many 1000+ citation papers. Additionally, this position offers:

　　Priority on quickly producing high-impact publications, taking advantage of unique Alzheimer's datasets at Rush University.

　　Thousands of post-mortem tissues available for person-specific AD models

　　Deeply phenotyped sample origins, with multiple omics, cognitive testing and neuroimaging

　　Sole access to the latest sequencing and cellular phenotyping equipment

　　Pursue highly novel targets and follow effects wherever they lead

　　Scientific focus in a flat organizational structure, with stable funding

　　Career development and grant-writing opportunities alongside highly successful scientists

　　Position Responsibilities:

　　Lead and perform range of lab-based experiments including reprogramming human somatic cells into induced pluripotent stem cells, stem cell banking and validations, stem cell differentiation into disease-relevant cell types, generating 2D and 3D culture models, phenotyping diseased cells with cellular, molecular and functional assays.

　　Oversee the day to day organization of different components of the projects.

　　Work collaboratively with other RADC teams who are working on related research questions.

　　Position Qualifications Include:

　　Ph.D. or MD or equivalent degree in the field of Neuroscience, Cell biology, Developmental biology, Stem cell biology or Molecular biology or a related Field

　　Excellent skills and experience in human iPSC derivation, stem cell culture and differentiation, 2D and organoid 3D culture

　　Excellent skills and experience in cellular and molecular biology and fluorescence imaging

　　Experience in calcium imaging, multielectrode array are highly desirable

　　Experience in genome editing and next gene sequencing is a plus

　　Excellent analytic and problem-solving skills

　　Excellent project planning and organization skills

　　Excellent written and oral communication skills

　　Proven ability to work independently and in collaborative team environments

　　Company Highlights:

　　Ranked among the top academic medical centers in the country, Rush University Medical Center is an outstanding place to enhance your career. Everything we do centers on one goal: improving patient care.

　　Rush's 14-story hospital Tower is the cornerstone of the Rush Transformation, and is the symbol of a philosophy-an evolution in the delivery of patient-centered care.

　　Rush offers a competitive salary, valuable healthy living benefits to include: health, dental and vision to help you maintain and improve your health. Rush also offers several ways to invest in your future. Whether you're saving for retirement or a child's education, Rush offers benefits to help you make the most of your moneynow and in the future.

　　Rush is an equal opportunity employer. We evaluate qualified applicants without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, veteran status, and other legally protected characteristics.

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