Postdoctoral Researcher in DNA Damage Responses and Cancer, laboratory of Dr. Roger Greenberg at the Perelman School of Medicine, University of Pennsylvania.

　　The laboratory of Dr. Roger Greenberg within the Cancer Biology Department at the University of Pennsylvania is seeking postdoctoral researchers to investigate fundamental mechanisms that impact genome integrity and cancer biology. Our group has pioneered novel approaches to dynamically visualize the molecular events responsible for homologous recombination DNA repair in mammalian cells. These methodologies will be used to interrogate canonical homologous recombination DNA repair by BRCA1 and BRCA2 as well as noncanonical homology directed mechanisms of telomere lengthening. We have also recently elucidated mechanisms underlying communication between DNA double-strand breaks and the immune system, which mediate DNA damage activated anti-tumor immune responses.

　　We are looking to appoint accomplished Postdoctoral Researchers in these areas. Candidates will have a PhD and/or MD in Biochemistry, Cell and Molecular Biology, or Immunology and an extensive publication record.

　　Application Instructions

　　Please submit your CV and a cover letter outlining your research interests, career goals and the names of up to three referees to Dr. Roger Greenberg at rogergr@pennmedicine.upenn.edu.

　　For details on our group, please visit our lab website at: http://www.med.upenn.edu/apps/faculty/index.php/p8145566

　　Relevant Publications

　　Harding SM, Benci JL, Irianto J, Discher DE, Minn AJ, and Greenberg RA. Mitotic progression following DNA damage enables pattern recognition within micronuclei, Nature 23:466-470, 2017

　　Verma P, Dilley RL, Zhang TP, Gyparaki MT, Li Y, and Greenberg RA. RAD52 and SLX4 Act Non-epistatically to ensure Telomere Stability During Alternative Telomere Lengthening. Genes Dev 2019 in press

　　Dilley RL, Verma P, Cho NW, Winters HD, Wondisford AR, and Greenberg RA. Break Induced Telomere Synthesis Underlies Homology Directed Telomere Maintenance. Nature 539(7627):54-58, 2016.

　　Cho NW, Dilley RL, Lampson MA, Greenberg RA: Interchromosomal Homology Searches Drive Directional ALT Telomere Movement and Synapsis. Cell 159(1): 108-21, September 2014.

　　Tang J, Cho NW, Cui G, Manion EM, Shanbhag NM, Botuyan MV, Mer G, Greenberg RA: Acetylation limits 53BP1 association with damaged chromatin to promote homologous recombination. Nat Struct Mol Biol 20(3): 317-25, March 2013

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