招聘信息：

　　我們正在尋找一位敏銳而有才華的博士后研究員加入我們?cè)诓⊥�醫(yī)院的轉(zhuǎn)化歐洲腫瘤學(xué)實(shí)驗(yàn)室。病童醫(yī)院的Ramaswamy實(shí)驗(yàn)室開(kāi)展了兒科腦腫瘤轉(zhuǎn)化基因組學(xué)研究，其首要目標(biāo)是為患有高危復(fù)發(fā)性腫瘤的兒童發(fā)現(xiàn)新的和新的療法。我們使用主要人類數(shù)據(jù)集與無(wú)偏見(jiàn)的化學(xué)和遺傳篩選相結(jié)合，為新的治療途徑提供信息，然后在穩(wěn)健的動(dòng)物模型中驗(yàn)證這些方法。我們?cè)噲D了解高風(fēng)險(xiǎn)兒科腦腫瘤對(duì)放療和化療的治療耐藥性，對(duì)髓母細(xì)胞瘤和室管膜瘤特別感興趣。我們也非常關(guān)注為預(yù)后和治療反應(yīng)開(kāi)發(fā)新的生物標(biāo)志物，并將這些與新的和新的療法相結(jié)合。

　　我們的實(shí)驗(yàn)室位于亞瑟和索尼亞拉巴特腦瘤研究中心，該研究中心是世界上最大和最具生產(chǎn)力的兒科腦腫瘤研究中心之一。我們有11名主要研究人員和120多名受訓(xùn)人員，研發(fā)空間為120000平方英尺，開(kāi)放式概念設(shè)置側(cè)重于腦瘤研究的各個(gè)方面。在過(guò)去20年中，我們的小組一直處于兒科腦腫瘤主要發(fā)現(xiàn)的最前沿，并且一直是所有類型小兒腦腫瘤基因組學(xué)的領(lǐng)導(dǎo)者。此外，我們是Sickkids研究所的發(fā)育和干細(xì)胞生物學(xué)計(jì)劃的一部分，為癌癥和干細(xì)胞生物學(xué)提供了非常豐富的專家環(huán)境。兒童醫(yī)院位于多倫多大學(xué)，瑪格麗特公主癌癥中心和安大略癌癥研究所的街對(duì)面，除了我在醫(yī)學(xué)生物物理系的所屬部門(mén)之外，我們還與世界一流的科學(xué)家進(jìn)行了廣泛的合作。我們的團(tuán)隊(duì)通過(guò)國(guó)家授權(quán)機(jī)構(gòu)提供充足的資金，并將提供豐富，有趣和培育的環(huán)境。

　　候選人必須已經(jīng)（或預(yù)計(jì)很快就會(huì)獲得）博士學(xué)位。并且在分子生物學(xué)，癌癥生物學(xué)或相關(guān)學(xué)科方面擁有豐富的經(jīng)驗(yàn)，并且理想地具有人類基因組學(xué)和/或功能基因組學(xué)的背景。這個(gè)職位將高度重視以下技能：

　　- 癌癥干細(xì)胞培養(yǎng)方法和流式細(xì)胞術(shù)

　　- 動(dòng)物模型，特別是正交異種移植物

　　- 理想情況下是R和/或Python的工作知識(shí)

　　- 使用遺傳學(xué)和組學(xué)數(shù)據(jù)的經(jīng)驗(yàn)

　　- 癌癥生物學(xué)知識(shí)是一個(gè)重要的優(yōu)點(diǎn)

　　- 一份或多份同行評(píng)審科學(xué)出版物的第一（或共同首位）作者

　　- 優(yōu)秀的英語(yǔ)口頭和書(shū)面溝通技巧

　　- 能夠獨(dú)立和團(tuán)隊(duì)合作

　　有興趣的候選人應(yīng)發(fā)送他們的簡(jiǎn)歷，先前研究經(jīng)驗(yàn)的總結(jié)，未來(lái)的研究興趣和職業(yè)目標(biāo)，以及vijayramaswamy79 @gmail.com的Vijay Ramaswamy博士的三個(gè)參考清單。

　　英文原文：

　　We are seeking a keen and talented postdoctoral fellow to join our translational euro-oncology laboratory at the Hospital for Sick Children. The Ramaswamy Lab at the Hospital for Sick Children performs studies of translational genomics of paediatric brain tumours with an overarching goal of discovering new and novel therapies for children with high-risk recurrent tumours. We use primary human datasets coupled with unbiased chemical and genetic screening to inform new treatment avenues, and then validate these approaches in robust animal models. We seek to understand treatment resistance to both radiation and chemotherapy in high risk paediatric brain tumours, with a specific interest in medulloblastoma and ependymoma. We also have a keen interest in developing new biomarkers for both prognosis and response to therapy and to combine these with new and novel therapies.

　　Our laboratory is located within the Arthur and Sonia Labatt Brain Tumour Research Centre which is one of the largest and productive paediatric brain tumour groups in the world. We have 11 principal investigators and over 120 trainees with 120000 sq ft. of research space, in an open concept setting focused on all aspects of brain tumour research. Our group have been at the forefront of major discoveries in paediatric brain tumours over the past 20 years, and have been a leader in the genomics of all types of paediatric brain tumours. Furthermore, we are part of the Programme in Developmental and Stem Cell Biology within the Sickkids Research Institute providing a very rich environment of experts in cancer and stem cell biology. The Hospital for Sick Children is located across the street from the University of Toronto, Princess Margaret Cancer Centre and Ontario Institute for Cancer Research where we have extensive collaborations in addition to my affiliation in the Department of Medical Biophysics provides access to world class scientists. Our group is well funded through national granting agencies, and will provide a rich, fun and nurturing environment.

　　Candidate must have received (or expect to receive soon) a Ph.D. and have extensive experience in molecular biology, cancer biology or related discipline and ideally have a background in human genomics and/or functional genomics. The following skills will be highly valued for this position:

　　-        Cancer stem cell culture methods and flow cytometry

　　-        Animal modelling, particularly orthotropic xenografts

　　-        Ideally a working knowledge in R and/or Python

　　-        Experience working with genetics and omics data

　　-        Knowledge of cancer biology is a major plus

　　-        First (or co-first) author of one or more peer-reviewed scientific publications

　　-        Excellent English verbal and written communication skills

　　-        Able to work both independently and in teams

　　Interested candidates should send their CV, summary of prior research experience, future research interests and career goals and a list of three references to Dr. Vijay Ramaswamy at vijayramaswamy79@gmail.com.

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