職位描述：

　　我們邀請了瑞典烏普薩拉大學免疫學，遺傳學和病理學系（IGP）血管生物學部門PontusAspenström研究小組的博士后任命申請。該研究小組正在研究Rho GTPases的Ras樣家族，它們是肌動蛋白絲系統(tǒng)的關鍵調(diào)節(jié)因子，從而控制重要的細胞過程，如細胞形態(tài)發(fā)生，細胞極性和細胞遷移。

　　該研究旨在闡明健康和疾病中Rho依賴的信號傳導機制。一組項目專注于Miro GTPases，它是線粒體穩(wěn)態(tài)和功能的關鍵參與者。它們在生理環(huán)境中的重要性也使它們成為神經(jīng)退行性疾病病理學中的重要蛋白質(zhì)。

　　另一組項目集中于所謂的非典型Rho GTPases的作用，Rho GTPases是Rho GTPases的一個亞類，用于治療惡性間皮瘤和膠質(zhì)母細胞瘤。主要目的是闡明非典型Rho GTP酶在癌細胞遷移和轉(zhuǎn)移中脫軌功能背后的機制，并確定藥物治療的新靶點。烏普薩拉大學免疫學，遺傳學和病理學系（www.igp.uu.se ）與幾個國際強大的研究小組有廣泛的研究概況。烏普薩拉大學是瑞典財團SciLifeLab.se（www.scilifelab.se）的一部分，該聯(lián)盟為高級生命科學研究提供最先進的基礎設施，包括化學生物學，藥物發(fā)現(xiàn)和開發(fā)以及先進光學顯微鏡平臺。

　　資格：

　　我們正在尋找一位積極進取，才華橫溢，受過良好教育的研究人員，在過去三年中，他在細胞生物學，神經(jīng)科學或相關研究課題中獲得博士學位。

　　優(yōu)點：

　　申請人應具有分子細胞生物學的強大背景和先進細胞生物學技術的實踐經(jīng)驗，包括顯微鏡和成像，是先決條件。候選人應具備出色的協(xié)作技能和國際研究經(jīng)驗

　　環(huán)境。

　　獎學金/工資：在獲得博士學位或同等學歷后的四年內(nèi)，可以授予進行博士后研究的獎學金最多兩年。該教育獎學金免稅。該金額一次設定為12個月，并按月支付。

　　申請：申請表必須包含以下英文文件：

　　1.履歷和資格

　　2.完整的出版物清單。

　　3.一封信，描述了加入該組織的動機以及當前研究的簡要總結(jié)（1-2頁）。

　　4.兩名參考人員的聯(lián)系方式。

　　申請將根據(jù)資格要求，相關研究領域的成就和個人適用性進行評估。

　　欲了解更多信息，請聯(lián)系PontusAspenström，pontus.aspenstrom @ upp.uu.se。我們拒絕提供招聘和廣告幫助。我們只按照廣告中描述的方式接受申請。

　　英文原文：

　　We invite applications for a postdoctoral appointment in the research group of Pontus Aspenström, in the Vascular Biology Unit at the Dept. of Immunology, Genetics and Pathology (IGP), Uppsala University, Sweden. The research group is studying the Ras-like family of Rho GTPases,which are key regulators of the actin filament system and thereby control vital cellular processes such as cell morphogenesis, cell polarity and cell migration.

　　The research is aimed to elucidate the Rho-dependent signalling mechanisms in health and disease. One set of projects focus on the Miro GTPases, which are key players in mitochondrial homeostasis and functioning. Their importance in a physiological context also makes them significant proteins in the pathology of neurodegenerative diseases.

　　Another set of projects focus on the role of the so-called atypical Rho GTPases, which is a subclass of the Rho GTPases, in malignant mesothelioma and glioblastoma. The principal goal is to elucidate the mechanisms behind the derailed function of atypical Rho GTPases in cancer cell migration and metastasis and to identify new targets for drug treatment.The Department of immunology, genetics and pathology at Uppsala University (www.igp.uu.se) has a broad research profile with several internationally strong research groups. Uppsala University is part of a Swedish consortium,SciLifeLab.se (www.scilifelab.se), which provides state-of the art infrastructure for advanced life science research including platforms for Chemical Biology, Drug Discovery and Development, and Advanced Light Microscopy.

　　Qualifications:

　　We are seeking a highly motivated, talented and well-educated researcher with a PhD degree awarded within the past three years in cell biology, neuroscience or in a related research topic.

　　Merits:

　　The applicant should have a strong background in molecular cell biology and practical experience of advanced cell biology techniques, including microscopy and imaging, is a prerequisite. The candidate should have excellent collaboration skills and experience in working in an international research

　　environment.

　　Scholarship/salary: Ascholarship for carrying out postdoctoral research can be granted for a maximum of two years within a four year period following the receipt of a doctoral degree or equivalent. This educational scholarship is tax-exempt. The amount is set for twelve months at a time and is paid out on a monthly basis.

　　Application: An application must contain the following documents in English:

　　1.Curriculum vitae and qualifications

　　2. A complete list of publications.

　　3. A letter describing the motivation to join the group and a brief summary of current research (1-2 pages).

　　4. Contact details for two reference persons.

　　The applications will be assessed based on eligibility requirements,achievements in related research areas, and personal suitability.

　　For more information, contact Pontus Aspenström, pontus.aspenstrom@igp.uu.se.We decline offers of recruitment and advertising help. We only accept the application the way described in the advertisement.

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