招聘信息：

　　隸屬于匹茲堡大學(xué)醫(yī)學(xué)院

　　博士后職位可用于在斯圖爾特 - 奧恩斯坦實(shí)驗(yàn)室進(jìn)行一項(xiàng)關(guān)于DNA損傷信號(hào)傳導(dǎo)的NCI資助項(xiàng)目。在最近在匹茲堡大學(xué)計(jì)算和系統(tǒng)生物學(xué)系建立的斯圖爾特-奧恩斯坦實(shí)驗(yàn)室，我們尋求了解DNA損傷信號(hào)如何在我們體內(nèi)的組織中進(jìn)行調(diào)整并在癌癥中進(jìn)行修飾，以開(kāi)發(fā)改進(jìn)的和更精確的靶向治療。我們的實(shí)驗(yàn)室位于希爾曼癌癥中心，并且位于匹茲堡大學(xué)的一個(gè)非常強(qiáng)大的基因組穩(wěn)定組中，該組在全國(guó)NIH資助中排名第五。

　　Stewart-Ornstein實(shí)驗(yàn)室使用濕式和干式實(shí)驗(yàn)室方法，并且兩者都?xì)g迎專(zhuān)業(yè)知識(shí)，盡管理想的候選人會(huì)對(duì)研究的兩個(gè)方面都感興趣。我們使用活細(xì)胞成像，單細(xì)胞方法，遺傳篩選（cas9ko，cas9i），基因組工具（RNA的NGS分析，ChIP，染色質(zhì)結(jié)構(gòu)）和數(shù)學(xué)模型來(lái)研究DNA損傷信號(hào)的變異并理解這種信號(hào)傳導(dǎo)的可能性被操縱以改善癌癥治療。項(xiàng)目最初將關(guān)注非遺傳細(xì)胞狀態(tài)如何改變DNA損傷反應(yīng)并促進(jìn)化療和放射治療后的持久性。 DNA損傷信號(hào)傳導(dǎo)與致癌和免疫信號(hào)傳導(dǎo)途徑之間的聯(lián)系也是感興趣的領(lǐng)域。

　　資格要求：

　　-PhD分子，系統(tǒng)或計(jì)算生物學(xué)或類(lèi)似的。

　　- 獨(dú)立和協(xié)作的工作，強(qiáng)大的寫(xiě)作和演講技巧

　　- 重要的出版記錄

　　有意者請(qǐng)將您的簡(jiǎn)歷和三個(gè)參考名稱(chēng)轉(zhuǎn)發(fā)給Jacob Stewart-Ornstein博士（JAS632@pitt.edu）。

　　匹茲堡大學(xué)提供全面的薪資計(jì)劃，并在無(wú)煙和無(wú)毒的工作場(chǎng)所提供卓越的福利。匹茲堡大學(xué)醫(yī)學(xué)院是一個(gè)肯定行動(dòng)/平等機(jī)會(huì)雇主，并鼓勵(lì)代表性不足的團(tuán)體提出申請(qǐng)。 EEO / AA / M / F獸醫(yī)/殘疾人士。

　　聯(lián)系人：

　　Jacob Stewart-Ornstein，博士

　　助理教授：

　　計(jì)算與系統(tǒng)生物學(xué)系

　　美國(guó)匹茲堡和希爾曼癌癥中心

　�。╡）jas632@pitt.edu

　　（p）4126233245

　�。╳）www.Stewart-Ornstein-Lab.com

　　Affiliated with University of Pittsburgh School of Medicine

　　Postdoctoral positions are available to pursue an NCI funded project on DNA damage signaling in the Stewart-Ornstein Laboratory. In the recently established Stewart-Ornstein Laboratory in Department of Computational and Systems Biology at the University of Pittsburgh we seek to understand how DNA damage signaling is tuned across tissues in our body and modified in cancers for the purposes of developing improved and more precisely targeted therapies. Our lab is based at the Hillman Cancer Center and embedded within a very strong genome stability group at the University of Pittsburgh, which ranks fifth in NIH funding nationally.

　　The Stewart-Ornstein laboratory uses both wet and dry lab approaches and expertise is welcomed in either, though the ideal candidate would have interest in both aspects of research. We use live cell imaging, single cell approaches, genetic screens (cas9ko, cas9i), genomic tools (NGS assays of RNA, ChIP, Chromatin structure), and mathematical models to study the variation in DNA damage signaling and to understand how this signaling might be manipulated to improve cancer therapy. Projects will initially focus on how non-genetic cellular states alter the DNA damage response and promote persistence after chemotherapy and radiation treatment. Linkages between DNA damage signaling and oncogenic and immune signaling pathways are also areas of interest.

　　Qualification Requirements

　　-PhD in molecular, systems, or computational biology or similar.

　　-Capable of independent and collaborative work, strong writing and presentation skills

　　-Significant publication record

　　Interested candidates please forward your curriculum vitae and names of three references to Dr. Jacob Stewart-Ornstein (JAS632@pitt.edu).

　　The University of Pittsburgh offers a comprehensive salary program and excellent benefits in a smoke and drug free workplace. The University of Pittsburgh School of Medicine is an Affirmative Action/Equal Opportunity Employer and encourages applications from under-represented groups. EEO / AA/ M /F Vets / Disabled.

　　Contact

　　Jacob Stewart-Ornstein, PhD

　　Assistant Professor

　　Dept. Computational and Systems Biology

　　U. Pittsburgh & Hillman Cancer Center

　　(e) jas632@pitt.edu

　　(p) 4126233245

　　(w) www.Stewart-Ornstein-Lab.com

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