招聘簡介：

　　哈佛醫(yī)學(xué)院肥胖相關(guān)神經(jīng)科學(xué)研究博士后研究員職位

　　哈佛醫(yī)學(xué)院波士頓兒童醫(yī)院內(nèi)分泌科的Ozcan實驗室（www.ozcanlab.com）有兩個博士后職位。研究內(nèi)質(zhì)網(wǎng)應(yīng)激信號在控制下丘腦代謝平衡、神經(jīng)元活動和瘦素抵抗中的作用。感興趣的候選人可以查看我們在這方面的最新出版物，更好地了解研究領(lǐng)域：A.Ozcan L等。細(xì)胞代謝。2009年1月7日；9（1）：35-51。內(nèi)質(zhì)網(wǎng)應(yīng)激對瘦素抵抗的發(fā)展起著中心作用。B.Liu J等人，細(xì)胞。2015年5月21日；161（5）：999-1011。西樂司特治療肥胖。C.Lee J等人，自然醫(yī)學(xué)。2016年9月；22（9）：1023-32。withaferin A是一種瘦素致敏劑，對小鼠有很強(qiáng)的抗糖尿病作用。D.Feng X等，自然醫(yī)學(xué)。2019年3月4日—在線出版。IL1R1是celastrol瘦素致敏和抗肥胖作用所必需的。兩個職位的理想候選人都應(yīng)該擁有博士、碩士或碩士/博士學(xué)位，在神經(jīng)科學(xué)和分子生物學(xué)方面有很強(qiáng)的經(jīng)驗，這一點在知名期刊的同行評審出版物中很明顯。第一位需要在神經(jīng)元單細(xì)胞電生理記錄的膜片鉗技術(shù)的專業(yè)知識。該職位的候選人必須具備神經(jīng)元電生理記錄和立體定向手術(shù)方面的專業(yè)知識。對于第二個職位，候選人應(yīng)具備神經(jīng)科學(xué)研究和分子生物學(xué)方面的專業(yè)知識：具有代謝內(nèi)穩(wěn)態(tài)中央控制經(jīng)驗的候選人將優(yōu)先獲得第二個職位。感興趣的學(xué)員應(yīng)將他們的研究興趣、履歷以及三名推薦人的姓名和聯(lián)系方式轉(zhuǎn)發(fā)給Umut Ozcan博士；電子郵件：umut.ozcan@children.harvard.edu。

　　英文原文：

　　Postdoctoral Fellow Position in Harvard Medical School For Obesity-Related Neuroscience Research

　　Two postdoctoral positions are available in the Ozcan Laboratory (www.ozcanlab.com) in the Division of Endocrinology, Boston Children’s Hospital, Harvard Medical School. The positions are offered to study the role of endoplasmic reticulum (ER) stress signaling in hypothalamic control of metabolic homeostasis, neuron activity and leptin resistance in obesity. The interested candidates can check our recent publications in this area to understand the area of research better: a. Ozcan L, et al. Cell Metabolism. 2009 Jan 7;9(1):35-51. Endoplasmic reticulum stress plays a central role in development of leptin resistance. b. Liu J et al., Cell. 2015 May 21;161(5):999-1011. Treatment of obesity with celastrol. c. Lee J et al., Nature Medicine. 2016 Sep;22(9):1023-32. Withaferin A is a leptin sensitizer with strong antidiabetic properties in mice. d. Feng X, et al., Nature Medicine. 2019 March 4-Online publication. IL1R1 is required for celastrol’s leptin-sensitization and antiobesity effects. The ideal candidates for both positions should have a Ph.D., M.D. or M.D./Ph.D. degrees with strong experience in neuroscience and molecular biology evident by peer-reviewed publications in reputable journals. Position one requires expertise in patch clamp technique for single cell electrophysiological recording of neurons. Candidates for this position must have expertise in electrophysiological recordings of neurons and stereotaxic surgeries. For position two, candidates should have expertise in neuroscience research and molecular biology: candidates with prior experience in central control of metabolic homeostasis will be given priority for position two. Interestedcandidates should forward their research interests, curriculum vitae along with the name and contact information of three referees to Dr. Umut Ozcan; e-mail: umut.ozcan@childrens.harvard.edu.

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