招聘簡介:

　　令人興奮的博士后培訓(xùn)機會在芝加哥大學(xué)開發(fā)新型流感疫苗

　　我們正在尋找一個博士后研究員來開發(fā)和測試新的通用流感疫苗候選人。

　　這個比爾和梅林達蓋茨基金會資助的職位將涉及B淋巴細(xì)胞和流感抗體反應(yīng)的研究，以開發(fā)新的通用流行性感冒病毒亞單位疫苗候選者。一種真正通用的流感疫苗接種策略必須控制病毒的逃逸突變，以及抗體對不同保護性和耐用性的表位和表位的反應(yīng)演變。該疫苗旨在通過選擇免疫原性和保護性抗原表位的抗體，以及遠離免疫原性但不具有保護性的抗原表位，從而提高對流感多個保守、保護性抗原表位的反應(yīng)，從而減少病毒逃逸。我們將使用一組獨特而強大的觀察、實驗和計算設(shè)計來開發(fā)這種候選疫苗�？偟膩碚f，這個項目將涉及三個研究所的四個小組的合作，包括芝加哥大學(xué)的帕特里克·威爾遜和莎拉·科比小組，西奈山伊坎醫(yī)學(xué)院的弗洛里安·克拉默實驗室，以及弗雷德·哈欽森癌癥中心的杰西·布魯姆實驗室。

　　英文原文:

　　Exciting postdoctoral training opportunity developing novel influenza vaccines at the University of Chicago

　　We are seeking a Postdoctoral Fellow to develop and test novel universal influenza vaccine candidates.

　　This Bill and Melinda Gates Foundation-funded position will involve studies of B lymphocyte and antibody responses to influenza for development of novel universal influenza vaccine candidates. A truly universal vaccination strategy against influenza must manage escape mutations by the virus and the evolution of antibody responses to and away from epitopes that differ in their protectiveness and durability. The proposed vaccine aims to minimize viral escape by boosting responses to multiple conserved, protective epitopes on influenza by selecting for antibodies to epitopes that are immunogenic and protective, and away from epitopes that are immunogenic but not protective. We will develop this candidate vaccine using a unique and powerful set of observations, experiment, and computational design. The over-all project will involve the collaborative efforts of four groups at three institutes, including: the groups of Patrick Wilson and Sarah Cobey at the University of Chicago, Florian Krammer’s laboratory at the Icahn School of Medicine at Mount Sinai, and Jesse Bloom’s laboratory at the Fred Hutchinson Cancer Center.

　　The position with will involve use of technologies such as flow cytometry, single-cell transcriptomics (i.e., 10x Genomics technology), plus generation and characterization of human monoclonal antibodies and ultimately production and testing of novel influenza vaccine candidates.

　　Candidates should have completed a doctorate level degree and have a strong background in vaccinology and/or immunology, preferably related to B cells and antibodies. The successful candidate should have documented success in research including publications in international journals on relevant topics. Compensation is dependent upon qualifications. The University provides a generous package of fringe benefits.

　　Applicants should submit an application package that includes a cover letter, CV, relevant prior publications, and contact information for three references to Patrick Wilson, at wilsonp@uchicago.edu.

　　Application review will begin immediately and continue until the position is filled.

　　Patrick C. Wilson. PhD

　　Professor of Medicine/ Section of Rheumatology

　　The Committee on Immunology

　　The University of Chicago

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