招聘簡(jiǎn)介:

　　Grant Challen博士的實(shí)驗(yàn)室有一個(gè)研究機(jī)會(huì)，該實(shí)驗(yàn)室研究基因突變?nèi)绾斡绊懝撬柚性煅�干�?xì)胞（造血干細(xì)胞='hscs”）的功能，并促進(jìn)血液癌的發(fā)展，如骨髓增生異常綜合征（=mds）、骨髓增生性neopoline。lasms（=“mpn”）、急性髓細(xì)胞白血病（=“aml”）和T細(xì)胞急性淋巴細(xì)胞白血�。�=“t-all”）。Challen實(shí)驗(yàn)室采用先進(jìn)的技術(shù)，如下一代測(cè)序、CRISPR/CAS9和高通量流式細(xì)胞術(shù)，在包含癌細(xì)胞系、轉(zhuǎn)基因小鼠模型和人類患者原代細(xì)胞的模型系統(tǒng)中研究這些過程。實(shí)驗(yàn)室的總體目標(biāo)是了解不同的過程如何有助于將正常的干細(xì)胞轉(zhuǎn)化為癌癥，目的是為血液癌患者確定新的治療方法。

　　成功的候選人將有機(jī)會(huì)參與任何項(xiàng)目，研究表觀遺傳修飾如何影響hsc的命運(yùn)決定，以及表觀遺傳調(diào)控因子的遺傳突變?nèi)绾未龠M(jìn)克隆造血中突變hsc的克隆擴(kuò)增，以及易轉(zhuǎn)化為造血惡性腫瘤。

　　博士后學(xué)者將負(fù)責(zé)管理自己的項(xiàng)目（在Challen博士的指導(dǎo)下），并與其他受訓(xùn)者一起參與正在進(jìn)行的項(xiàng)目。必須具備故障排除技能、獨(dú)立的分析思維和研究計(jì)劃技能，并具有獨(dú)立工作和與實(shí)驗(yàn)室工作人員和研究人員溝通的能力。有流式細(xì)胞儀和小動(dòng)物處理經(jīng)驗(yàn)是可取的，但不是必要的。有學(xué)習(xí)這些技巧的意愿者優(yōu)先。

　　英文原文：

　　There is an opportunity for research in the laboratory of Dr. Grant Challen, which studies how genetic mutations influence the function of blood-forming stem cells in the bone marrow (hematopoietic stem cells = ‘”HSCs”) and contribute to the development of blood cancers such as myelodysplastic syndromes (= “MDS”), myeloproliferative neoplasms (= “MPN”), acute myeloid leukemia (= “AML”) and T-cell acute lymphoblastic leukemia (= “T-ALL”). The Challen lab using cutting-edge techniques such as next-generation sequencing, CRISPR/Cas9 and high-throughput flow cytometry to investigate these processes in model systems incorporating cancer cell lines, transgenic mouse models, and primary cells from human patients. The overall goal of the lab is to understand how different processes contribute to turning a normal stem cell into cancer, with the aim of identifying new treatment approaches for patients with blood cancers.

　　The successful candidate will have the opportunity to work on any number of projects investigating how epigenetic modifications influence HSC fate decisions, and how genetic mutations in epigenetic regulators contribute to clonal expansion of mutant HSCs in clonal hematopoiesis, and predispose for transformation to hematopoietic malignancies.

　　The post-doctoral scholar will be responsible for managing their own projects (under the mentorship of Dr. Challen) as well as contributing to ongoing projects with other trainees. Must have troubleshooting skills, independent analytical thinking and research planning skills as well as demonstrated ability to work independently and communicate with the laboratory staff and investigators. Experience in flow cytometry and small animal handling is desirable, but not essential. Willingness to learn these techniques is preferred.

　　For more information about our lab research please visit our website (www.challenlab.com) and follow us on Twitter (challenlab). Qualified candidates can contact Dr. Grant Challen (grantchallen@wustl.edu) with CV and research statement attached.

為防止簡(jiǎn)歷投遞丟失請(qǐng)抄送一份至：boshijob@126.com（郵件標(biāo)題格式：應(yīng)聘職位名稱+姓名+學(xué)歷+專業(yè)+中國(guó)博士人才網(wǎng)）