招聘簡介:

　　Max Delbr_ck分子醫(yī)學中心（MDC）是德國聯(lián)邦政府和柏林土地支持的赫爾姆霍茲國家研究中心協(xié)會成員。對于皮質(zhì)發(fā)育中的分子通路，我們正在盡快尋找

　　博士后科學家

　　描述：

　　在發(fā)育中的中樞神經(jīng)系統(tǒng)（CNS）中，許多信號通路協(xié)同工作，以確保神經(jīng)干細胞被適當引導產(chǎn)生祖細胞，這些祖細胞成熟為神經(jīng)元和膠質(zhì)細胞。精確調(diào)節(jié)形態(tài)原和生長因子活性是神經(jīng)祖細胞和早期胚胎腦模式正常命運決定的核心。許多患者的先天性畸形，包括前腦無裂畸形（hpe）和神經(jīng)管閉合缺損（ntds），都涉及到聲波刺猬（shh）和Wntisigning機械部件的突變。來自動物模型和患有hpe和ntds的人類患者的數(shù)據(jù)在闡明形態(tài)發(fā)生的生物發(fā)生和細胞內(nèi)下游途徑方面取得了重大進展。然而，在信號識別和細胞內(nèi)和細胞間轉(zhuǎn)運形態(tài)原的水平上的途徑仍然沒有很好的特征。

　　我們的工作重點是低密度脂蛋白受體相關(guān)蛋白（LRP）家族的細胞內(nèi)受體在調(diào)節(jié)SHH、Wnt信號傳導和葉酸攝取中的作用。特別地，我們研究了在神經(jīng)發(fā)育過程中以及在成人皮質(zhì)干細胞生態(tài)位中，靶細胞表面信號識別和解釋水平上形態(tài)發(fā)生和生長因子活性的復雜調(diào)節(jié)。

　　總的來說，我們旨在闡明調(diào)節(jié)神經(jīng)前體細胞分化的分子機制。我們使用小鼠模型和神經(jīng)干細胞培養(yǎng)以及頭側(cè)移植物培養(yǎng)來研究這些問題。

　　英文原文：

　　The MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE (MDC) is a member of the Helmholtz Association of National Research Centers, supported by the Federal Government of Germany and the Land Berlin. For the Molecular Pathways in Cortical Development, we are looking as soon as possible for one

　　Postdoctoral Scientist

　　Description:

　　In the developing central nervous system (CNS) many signalling pathways work in concert to ensure that neural stem cells are appropriately directed to generate progenitor cells, which mature into neurons and glia. Precise regulation of morphogen and growth factor activity is central to normal fate decision of neuronal progenitors and early embryonic brain patterning. Many congenital malformations in patients including holoprosencephaly (HPE) and neural tube closure defects (NTDs) involve mutations in components of the sonic hedgehog (SHH) and WNTsignalling machineries. Data from animal models and human patients suffering fromHPE and NTDs has driven significant progress in elucidating the biogenesis and the intracellular downstream pathways of morphogens. However, the pathways at the level of signal recognition and intra- and intercellular trafficking of morphogens are still poorly characterized.

　　Our work focuses on the role of the endocytic receptors of the low density lipoprotein receptor related protein (LRP) family in modulating SHH, WNT signalling and folate uptake. In particular, we study the complex regulation of morphogen and growth factor activity at the level of signal recognition and interpretation on the surface of the target cells during neural development and in the adult cortical stem cell niche.

　　Overall we aim at elucidating molecular mechanisms that regulate the differentiation of neural precursor cells. We study these questions both in vivo using mouse models and in vitro using neural stem cell cultures and cephalic explant cultures.


　　Requirements:

　　Preferred qualifications:



　　- Ph.D. in biology or related field with publications in peer reviewed journals.


　　- Proficient in mouse genetics, mouse disease models, developmental biology, neurobiology.


　　- Skills with common high resolution imaging techniques.



　　- Familiarity with transcriptomic and proteomic techniques and analyses.



　　- Team working skills to address scientific questions. Excellent communication skills for working in multidisciplinary teams and with international colleagues at the MDCand with collaboration partners.


　　The initial contract will be for 2 years with the possibility of prolongation.

　　Salary is according to the German E 13 TVöD/Bund.

　　The MDC is an equal opportunity employer and promotes gender equality. The MDCis committed to raising the proportion of women in science and technology; we thus strongly encourage female researchers and specialists to apply.
MDC postdoctoral researchers benefit from the professional developmental program, which aims to enhance research experiences and career opportunities.
For more information click https://www.mdc-berlin.de/de/content/beruf-und-familie


　　For further information please contact:

　　Dr. Annette Hammes-Lewin


　　Department of Neuroscience


　　Max Delbrück Center for Molecular Medicine



　　hammes@mdc-berlin.de


　　Please, send your application including all documents indicating the registration number 11068/2019 until April 4, 2019 preferably by e-mail as pdf files (2 files of 5 MB at the maximum) as we do not return any papers to:

　　MAX DELBRÜCK CENTRUM FOR MOLECULAR MEDICINE

　　Personnel Department • POB 74 02 38 • 13092 Berlin

　　jobs@mdc-berlin.de • www.mdc-berlin.de

為防止簡歷投遞丟失請抄送一份至：boshijob@126.com（郵件標題格式：應聘職位名稱+姓名+學歷+專業(yè)+中國博士人才網(wǎng)）