招聘簡介：

　　在密歇根大學(xué)生命科學(xué)研究所的實(shí)驗(yàn)室里，積極進(jìn)取、有組織的個(gè)人尋求一個(gè)研究員的職位。研究項(xiàng)目旨在通過調(diào)節(jié)棕色和米色脂肪細(xì)胞的適應(yīng)性熱生成，確定可用于治療肥胖和相關(guān)代謝紊亂的靶點(diǎn)。我們最近發(fā)現(xiàn)了一種新的米色脂肪激活調(diào)控途徑（自然醫(yī)學(xué)，2018，24（6）：814-822）。這項(xiàng)研究是由NIH、ADA和許多其他資助機(jī)構(gòu)資助的。申請者擁有不到12個(gè)月的學(xué)位后工作經(jīng)驗(yàn)，可以申請兩個(gè)具有高度聲望和競爭力的博士后項(xiàng)目：密歇根生命科學(xué)研究生項(xiàng)目（https://lifecifellows.umich.edu）和密歇根博士后先鋒項(xiàng)目（https://umichchiproferprogram.org/），這兩個(gè)項(xiàng)目都提供額外的薪水和財(cái)務(wù)回報(bào)。資料來源，以及研究思路的靈活性和自由度。

　　實(shí)驗(yàn)職責(zé)包括但不限于：

　　分子生物學(xué)、PCR、DNA和RNA純化、質(zhì)粒克隆、qpcr基因表達(dá)分析和Western blotting。具有永生化細(xì)胞系和原代細(xì)胞分離和分化的哺乳動物細(xì)胞培養(yǎng)。逆轉(zhuǎn)錄病毒或腺病毒技術(shù)是首選。該研究將涉及基因嚙齒動物模型，因此有小鼠遺傳學(xué)和動物生理學(xué)經(jīng)驗(yàn)者優(yōu)先。有代謝方面的經(jīng)驗(yàn)者優(yōu)先。

　　英文原文：

　　Highly motivated, organized individual sought for a position as a research fellow in a laboratory at the Life Sciences Institute of the University of Michigan. Research Project aims to identify targets that can be exploited therapeutically for the treatment of obesity and associated metabolic disorders, through regulating adaptive thermogenesis in brown and beige adipocytes. We recently identified a novel regulatory pathway for beige fat activation (Nature Medicine, 2018, 24(6): 814-822). The research is funded by grants from NIH, ADA and many other funding agencies. Applicants have less than 12 months post-degree experience may be eligible to apply two highly prestigious and competitive postdoc programs: Michigan Life Science Fellows Programs (https://lifescifellows.umich.edu) and Michigan Postdoctoral Pioneer Program (https://umichpioneerprogram.org/), both of which provide additional salary and financial resources, along with flexibility and freedom to pursue research ideas.

　　Experimental duties will include but are not limited to:

　　Molecular biology, PCR, DNA and RNA purification, plasmid cloning, gene expression analysis by qPCR and western blotting. Mammalian cell culture with both immortalized cell lines and primary cell isolation and differentiation. Retroviral or adenoviral techniques are preferred. The research will involve genetic rodent models, so experience with mouse genetics and animal physiology is preferred. Experience in the metabolic field is preferred.

　　Starting date: ASAP

　　Required Qualifications:

　　Ph.D. in fields related to biomedical sciences, publications in high profile journals as a primary author and three experts in the related fields as references.

　　Please contact: wujunz@umich.edu

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