招聘簡(jiǎn)介：

　　紐約哥倫比亞大學(xué)歐文醫(yī)學(xué)中心腎臟科的西蒙·桑娜·切爾奇博士的實(shí)驗(yàn)室里有一位博士后研究科學(xué)家或博士后研究員職位。

　　實(shí)驗(yàn)室

　　Sanna Cherchi實(shí)驗(yàn)室致力于了解腎病的遺傳基礎(chǔ)，特別強(qiáng)調(diào)先天性腎、尿路畸形和原發(fā)性腎小球腎炎。

　　在過去的12年中，桑納·切爾奇博士在全球20多個(gè)國(guó)家建立了一個(gè)研究者網(wǎng)絡(luò)，招募患者進(jìn)行基因研究。他的工作涉及整個(gè)基因組學(xué)研究領(lǐng)域。為了補(bǔ)充人類特征的測(cè)序方法，他開發(fā)了新的小鼠先天性尿路缺陷模型，并使用斑馬魚模型來解剖與發(fā)育缺陷相關(guān)的結(jié)構(gòu)變體內(nèi)的基因。實(shí)驗(yàn)室的新場(chǎng)所涉及人類基因組學(xué)與單細(xì)胞和單核轉(zhuǎn)錄組學(xué)的結(jié)合，以及由攜帶腎病突變的患者產(chǎn)生的ipscs。他的研究為兒童腎臟疾病和神經(jīng)發(fā)育表型（包括自閉癥、智力障礙、精神分裂癥等）之間提供了強(qiáng)有力的基因聯(lián)系，并在腎臟學(xué)領(lǐng)域之外產(chǎn)生了重要影響。

　　他的研究成果發(fā)表在最著名的期刊上，包括《新英格蘭醫(yī)學(xué)雜志》（20132017）、《自然遺傳學(xué)雜志》（2018）、《臨床研究雜志》（2015、2018）、《美國(guó)人類遺傳學(xué)雜志》（2007、2012、2015、2017）、《美國(guó)腎臟學(xué)會(huì)雜志》（2005、2009、2014）、《腎臟內(nèi)科學(xué)雜志》（Kidney Internatio）。NAL（2011年、2015年）和許多其他。http://www.ncbi.nlm.nih.gov/pubmed/？術(shù)語(yǔ)=sanna cherchi+s）。

　　Sanna Cherchi博士資金雄厚，有來自美國(guó)國(guó)立衛(wèi)生研究院、國(guó)防部和其他機(jī)構(gòu)的多項(xiàng)資助；此外，他還為他的受訓(xùn)者提供了強(qiáng)有力的履歷記錄（美國(guó)大學(xué)婦女協(xié)會(huì)、AAW獎(jiǎng)學(xué)金、KNWAUT MuelEN Grand；荷蘭腎臟基金會(huì)博士后獎(jiǎng)學(xué)金）；腎臟學(xué)研究會(huì)；美國(guó)腎臟學(xué)學(xué)會(huì)博士后研究會(huì)；NIDDK F和T補(bǔ)助金）。實(shí)驗(yàn)室里的受訓(xùn)者得到了非常有競(jìng)爭(zhēng)力的薪水。

　　位置

　　我們正在尋找一位雄心勃勃、充滿熱情和動(dòng)力的研究人員，在高度動(dòng)態(tài)的環(huán)境中接受培訓(xùn)，接觸人類遺傳學(xué)、計(jì)算基因組學(xué)、發(fā)育生物學(xué)和干細(xì)胞研究領(lǐng)域的世界知名研究人員。該候選人將研究具有廣泛醫(yī)學(xué)相關(guān)性的兒科腎病的人類遺傳學(xué)，通過使用最新的最先進(jìn)的基因組工具來識(shí)別對(duì)表型有重大影響的罕見變異，并將基因組方法與單細(xì)胞分析以及干細(xì)胞生物學(xué)和發(fā)育遺傳學(xué)相結(jié)合。候選人將有自己的項(xiàng)目，并有機(jī)會(huì)與實(shí)驗(yàn)室的其他研究人員合作，研究大規(guī)�；�因組數(shù)據(jù)和脊椎動(dòng)物功能建模。

　　英文原文：

　　A Postdoctoral Research Scientist or Postdoctoral Research Fellow position is available in the laboratory of Dr. Simone Sanna-Cherchi in the Division of Nephrology at Columbia University Irving Medical Center, New York, New York.

　　The Laboratory

　　The Sanna-Cherchi lab is focused on understanding the genetic basis of kidney disease, with special emphasis on congenital malformation of the kidney and urinary tract and primary glomerulonephritis.

　　During the past 12 years Dr. Sanna-Cherchi established a network of investigators across more than 20 countries worldwide recruiting patients for genetic studies. His work spans the entire spectrum of genomics research. To complement his sequencing approaches for human traits, he has developed new mouse models for congenital defects of the urinary tract, and he is using zebrafish modeling to dissect genes within structural variants associated with developmental defects. New venues in the lab involve the integration of human genomics with use of single cell and single nucleus transcriptomics and development of iPSCs from patients carrying mutations causal for kidney disease. His work provided a strong genetic link between pediatric kidney diseases and neurodevelopmental phenotypes, including autism, intellectual disability, schizophrenia, and others, with important repercussions beyond the field of nephrology.

　　His work has been published in the most prestigious journals, including the New England Journal of Medicine (2013,2017), Nature Genetics (2018), the Journal of Clinical Investigation (2015, 2018), the American Journal of Human Genetics (2007, 2012, 2015, 2017), the Journal of the American society of Nephrology (2005, 2009, 2014), Kidney International (2011, 2015) and many others. http://www.ncbi.nlm.nih.gov/pubmed/?term=sanna-cherchi+s ).

　　Dr. Sanna-Cherchi is well funded, with multiple grants from the National Institute of Health, the Department of Defense and others; moreover, he has a strong track record for securing funding for his trainees (American Association of University Women, AAUW Fellowship; KNAW Ter Muelen Grant; Dutch Kidney Foundation Postdoctoral Fellowship; Italian Society of Nephrology Fellowship; American Society of Nephrology Postdoctoral Fellowship; NIDDK F and T grants). Trainees in the lab receive a very competitive salary.

　　The Position

　　We are looking for an ambitious, enthusiastic and motivated researcher to train in a highly dynamic environment with exposure to world-renowned investigators in the field of human genetics, computational genomics, developmental biology, and stem cells research. The candidate will work on human genetics of pediatric kidney disease of broad medical relevance, by using novel state-of-the-art genomic tools to identify rare variants with large effect on the phenotype and integrate genomic approaches with single cell analyses as well as stem cell biology and developmental genetics. The candidate will have his or her own project and will have the opportunity to collaborate with other investigators in the lab working on large-scale genomic data and on functional modeling in vertebrates.

　　Desired Qualifications

　　The desired qualifications for the position are: 1) a M.D. or Ph.D. degree (preferably in Genomics, Molecular Genetics, Statistics, Bioinformatics, Computer Science, Physics, or a related field), and significant experience with large-scale genomic studies; 2) solid skills in at least one programming language (python, perl, R or C/C++); 3) practical experience in large-scale bioinformatics data analysis with familiarity with both microarray and next-generation sequencing data; 4) experience with human-derived pluripotent stem cells; 5) excellent oral and written communication skills; 6) high enthusiasm, a strong work ethic and a willingness to push the envelope.

　　Please email a curriculum vitae and contact information for three references to: Dr. Simone Sanna-Cherchi, Columbia University Irving Medical Center, Department of Medicine, Division of Nephrology, New York, NY 10032, email: ss2517@cumc.columbia.edu

　　Columbia University is an Equal Opportunity/Affirmative Action employer —Race/Gender/Disability/Veteran.

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