招聘簡(jiǎn)介：

　　Grant Challen博士的實(shí)驗(yàn)室有一個(gè)研究機(jī)會(huì)，該實(shí)驗(yàn)室研究基因突變?nèi)绾斡绊懝撬柚性煅�干�?xì)胞（造血干細(xì)胞='hscs”）的功能，并促進(jìn)血液癌的發(fā)展，如骨髓增生異常綜合征（=mds）、骨髓增生性neopoline。lasms（=“mpn”）、急性髓細(xì)胞白血�。�=“aml”）和T細(xì)胞急性淋巴細(xì)胞白血�。�=“t-all”）。Challen實(shí)驗(yàn)室采用先進(jìn)的技術(shù)，如下一代測(cè)序、CRISPR/CAS9和高通量流式細(xì)胞術(shù)，在包含癌細(xì)胞系、轉(zhuǎn)基因小鼠模型和人類患者原代細(xì)胞的模型系統(tǒng)中研究這些過(guò)程。實(shí)驗(yàn)室的總體目標(biāo)是了解不同的過(guò)程如何有助于將正常的干細(xì)胞轉(zhuǎn)化為癌癥，目的是為血液癌患者確定新的治療方法。

　　英文原文：

　　There is an opportunity for research in the laboratory of Dr. Grant Challen, which studies how genetic mutations influence the function of blood-forming stem cells in the bone marrow (hematopoietic stem cells = ‘”HSCs”) and contribute to the development of blood cancers such as myelodysplastic syndromes (= “MDS”), myeloproliferative neoplasms (= “MPN”), acute myeloid leukemia (= “AML”) and T-cell acute lymphoblastic leukemia (= “T-ALL”). The Challen lab using cutting-edge techniques such as next-generation sequencing, CRISPR/Cas9 and high-throughput flow cytometry to investigate these processes in model systems incorporating cancer cell lines, transgenic mouse models, and primary cells from human patients. The overall goal of the lab is to understand how different processes contribute to turning a normal stem cell into cancer, with the aim of identifying new treatment approaches for patients with blood cancers.

　　The successful candidate will have the opportunity to work on any number of projects investigating how epigenetic modifications influence HSC fate decisions, and how genetic mutations in epigenetic regulators contribute to clonal expansion of mutant HSCs in clonal hematopoiesis, and predispose for transformation to hematopoietic malignancies.

　　The post-doctoral scholar will be responsible for managing their own projects (under the mentorship of Dr. Challen) as well as contributing to ongoing projects with other trainees. Must have troubleshooting skills, independent analytical thinking and research planning skills as well as demonstrated ability to work independently and communicate with the laboratory staff and investigators. Experience in flow cytometry and small animal handling is desirable, but not essential. Willingness to learn these techniques is preferred.

　　For more information about our lab research please visit our website (www.challenlab.com) and follow us on Twitter (challenlab). Qualified candidates can contact Dr. Grant Challen (grantchallen@wustl.edu) with CV and research statement attached.

　　Washington University is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, age, sex, sexual orientation, gender identity or expression, national origin, genetic information, disability, or protected veteran status….

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