招聘簡介：

　　德國癌癥研究中心是德國最大的生物醫(yī)學研究機構。我們擁有約3000名員工，在癌癥研究領域開展了廣泛的科學項目。

　　調(diào)控基因組學和癌癥進化的部門正在尋求

　　博士后研究員（參考號：2019-0102）

　　描述：

　　Odom實驗室通過實驗探索哺乳動物轉(zhuǎn)錄和轉(zhuǎn)錄調(diào)節(jié)進化的機制，以及這如何促進我們對癌癥基因組的理解。我們的最終目標是了解這些轉(zhuǎn)錄因子網(wǎng)絡的擾動如何影響人類癌癥的發(fā)生和發(fā)展。奧多姆實驗室采用綜合和協(xié)作的方法，與丹麥自由貿(mào)易區(qū)、歐洲生物信息學研究所、英國欣克斯頓歐洲生物信息學研究所和海德堡大學的研究小組密切合作。

　　一個成功的候選人將在與奧多姆博士的密切討論中，在設計他們的研究項目方面擁有不同尋常的自由度。目前，奧多姆實驗室的研究項目包括：研究CTCF如何在老化過程中為脊椎動物基因組提供穩(wěn)定性，老化相關的細胞間轉(zhuǎn)錄變異增加的機制，以及哺乳動物生長發(fā)育的比較功能基因組學。

　　項目包括與計算和臨床合作伙伴以及其他具有不同專業(yè)領域的Odom實驗室團隊成員密切合作。負責項目管理、方法開發(fā)和優(yōu)化、新的和大型基因組數(shù)據(jù)集的收集和分析。

　　英文原文：

　　The German Cancer Research Center is the largest biomedical research institution in Germany. With approximately 3,000 employees, we operate an extensive scientific program in the field of cancer research.

　　The Division of Regulatory Genomics and Cancer Evolution is seeking a

　　Postdoctoral Fellow

　　(Ref-No. 2019-0102)

　　Description:

　　The Odom laboratory experimentally explores the mechanisms of transcriptional and transcriptional regulatory evolution in mammals and how this informs our understanding of the cancer genome. Our eventual goal is to understand how perturbation of these transcription factor networks can influence cancer inception and progression in humans. The Odom laboratory uses an integrative and collaborative approach, working closely with research groups at DKFZ, EMBL, the European Bioinformatics Institute in Hinxton UK and at Heidelberg University.

　　A successful candidate will have unusual latitude in designing their research project in close discussions with Dr. Odom. Currently available research projects in the Odom laboratory include: investigation of how CTCF lends stability to vertebrate genomes during ageing, the mechanisms underlying ageing associated increases in cell-to-cell transcriptional variability and the comparative functional genomics of mammalian somatogenesis.

　　Projects involve close collaboration with computational and clinical partners and other Odom laboratory team members with different areas of expertise. The post holder will be responsible for project management, method development and optimisation, collection and analysis of novel and large genomic datasets.

　　For more information on Odom laboratory research, please see:

　　https://scholar.google.co.uk/citations?hl=en&user=I4QxyoQAAAAJ

　　Your profile:

　　We are seeking a postdoctoral research fellow with extensive molecular biology / genomics expertise to join our efforts, who is collaborative, ambitious, meticulous, scientifically adventurous and curiosity-driven. Prior research experience in single-cell methodologies, transcription, transcriptional regulation, epigenetics, evolutionary biology, bioinformatics and/or comparative genomics would be advantageous. We also encourage applications from accomplished graduate students seeking to switch research fields. The DKFZ (and Dr. Odom as a mentor) strongly encourages candidate-driven efforts to obtain competitive fellowships and career development awards.

　　The position is limited to 2 years.

　　The position can in principle be part-time.

　　For further information please contact

　　Dr. Duncan Odom, phone +49 622142-3446.

　　The German Cancer Research Center is committed to increase the percentage of female scientists and encourages female applicants to apply. Among candidates of equal aptitude and qualifications, a person with disabilities will be given preference.

　　To apply for a position please use our online application portal (www.dkfz.de).

　　We ask for your understanding that we cannot return application documents that are sent to us by post (Deutsches Krebsforschungszentrum, Personalabteilung, Im Neuenheimer Feld 280, 69120 Heidelberg) and that we do not accept applications submitted via email. We apologize for any inconvenience this may cause.

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