招聘簡介：

　　研究領(lǐng)域：癌癥免疫學(xué)與免疫治療

　　職位描述：匹茲堡大學(xué)外科腫瘤學(xué)部外科系在Kammula實(shí)驗(yàn)室為一位才華橫溢、充滿激情的博士后研究員/助理立即開放。外科腫瘤學(xué)的主要目標(biāo)是通過免疫學(xué)、病毒學(xué)和分子生物學(xué)技術(shù)開發(fā)治療癌癥的新方法，并將研究結(jié)果轉(zhuǎn)化為患者治療。我們有興趣招募博士或醫(yī)學(xué)博士/博士候選人，為專注于癌癥采用T細(xì)胞療法的實(shí)驗(yàn)室工作。詳細(xì)的實(shí)驗(yàn)室研究興趣見PMID:28395880；PMID:26712692；PMID:26100671；PMID:25424856。

　　博士后研究員將致力于獨(dú)立和合作的項(xiàng)目，開發(fā)用于晚期癌癥的過繼T細(xì)胞免疫療法。成功的申請(qǐng)者將采用克隆T細(xì)胞受體的策略，并用針對(duì)惡性腫瘤抗原的TCR基因修飾人類T細(xì)胞。利用人T細(xì)胞和鼠體內(nèi)模型進(jìn)行的體外研究將用于開發(fā)和測試新型T細(xì)胞療法。博士后研究員將進(jìn)行相關(guān)研究，以評(píng)估抗原特異性T細(xì)胞在過繼性T細(xì)胞免疫治療的人類臨床試驗(yàn)中的轉(zhuǎn)移、持續(xù)性和功能。該職位將涉及與聚合酶鏈反應(yīng)，克隆，載體設(shè)計(jì)，以及細(xì)胞培養(yǎng)，流式細(xì)胞術(shù)，細(xì)胞間染色，輸血，andelisa/elispot的分子工作。

　　英文原文：

　　Research Area: Cancer Immunology and Immunotherapy

　　Position Description: The Department of Surgery, Division of Surgical Oncology at the University of Pittsburgh has an immediate opening in the Kammula Lab for a talented and passionate postdoctoral fellow/associate. The Division of Surgical Oncology’s primary goal is to develop novel methods for treating cancers through immunology, virology, and molecular biology techniques, and to translate research findings into patient treatments. We are interested in recruiting PhD or MD/PhD candidates for a laboratory that focuses on adoptive T cell therapies for cancer.  Please see PMID: 28395880; PMID: 26712692; PMID: 26100671; PMID: 25424856 for detailed lab research interest.

　　The post-doctoral research fellow will work on independent and collaborative projects developing adoptive T cell immunotherapy for advanced cancers. The successful applicant will employ strategies for cloning T cell receptors and genetic modification of human T cells with TCRs specific for antigens expressed by malignancies. In vitro studies using human T cells and in vivo murine models will be used to develop and test novel T cell therapies. The post-doctoral fellow will perform correlative studies to evaluate the transfer, persistence and function of antigen-specific T cells in human clinical trials of adoptive T cell immunotherapy. The position will involve molecular work with PCR, cloning, vector design, as well as cell culture, flow cytometry, intercellular staining, transfections, andELISA/ELISPOT.

　　Candidates that have an interest in mechanistic and translational studies in cancer immunology and immunotherapy are encouraged to apply. The qualified applicants will be required to conduct research, interpret results, prepare manuscripts, and aid in the preparation of grant applications. The required expertise includes all common molecular biology and cellular immunology techniques, molecular cloning, cell culture, and experience with murine in vivo models. The applicant should have command of the English language, good interpersonal skills, critical thinking ability and evidence of experience and good writing skills through first author publications in peer reviewed journals. The applicant should also be proficient in computer software usage including Word, Excel, PowerPoint, and statistical packages.

　　To be considered for one of these positions, please provide a one-page statement of research interest, a current curriculum vitae and contact information for three-references to: surgoncapplicants@upmc.edu.

　　Employer Name: The University of Pittsburgh

　　Position Location: Pittsburgh, PA

　　Disclaimers: The University of Pittsburgh offers competitive compensation and benefits packages. “The University of Pittsburgh is an EEO/AA/M/F/Vets/Disabled employer”.

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