招聘簡(jiǎn)介：

　　工資：7年級(jí)：32236英鎊-39609英鎊/年。

　　一位博士后研究員有機(jī)會(huì)加入沃爾特·布默爵士的研究小組，該小組致力于結(jié)直腸癌的遺傳學(xué)、細(xì)胞生物學(xué)和分化研究，特別關(guān)注新型免疫療法的發(fā)展。您的主要職責(zé)是開(kāi)發(fā)和執(zhí)行針對(duì)腫瘤決定因素的雙特異性單克隆抗體以及與T淋巴細(xì)胞結(jié)合的表面標(biāo)志物的臨床前測(cè)試。這將涉及使用實(shí)驗(yàn)室廣泛收集的120多個(gè)主要具有完全特征的結(jié)直腸癌（CRC）衍生細(xì)胞系以及從新獲得的CRC活檢獲得的CRC類(lèi)有機(jī)物。你還將在其他項(xiàng)目中幫助控制分化和肌成纖維細(xì)胞/上皮細(xì)胞相互作用，這些項(xiàng)目由研究生和實(shí)驗(yàn)室的訪客負(fù)責(zé)。這將包括為研究小組經(jīng)驗(yàn)不足的成員提供指導(dǎo)。

　　你將適應(yīng)現(xiàn)有的，并開(kāi)發(fā)新的，科學(xué)的技術(shù)和實(shí)驗(yàn)方案，并將被期望為新的研究項(xiàng)目開(kāi)發(fā)和貢獻(xiàn)想法。

　　英文原文：

　　Salary: Grade 7: £32,236 - £39,609 p.a.

　　An opportunity has arisen for a Postdoctoral Researcher to join Sir Walter Boomer’s research group working on the genetics, cell biology and differentiation of colorectal cancer, with a special interest in the development of novel immunological therapies. Your main role will be to develop and carry out preclinical testing of bispecific monoclonal antibodies targeted against tumour determinants as well as T lymphocyte engaging surface markers. This will involve the use of the laboratory’s extensive collection of more than 120, mostly fully characterised, colorectal cancer (CRC) derived cell lines as well as CRC organoids derived from freshly obtained CRC biopsies. You will also be expected to help in other projects on aspects of the control of differentiation and myofibroblast/epithelial cell interactions being undertaken by graduate students and visitors in the laboratory. This will include providing guidance to less experienced members of the research group.

　　You will adapt existing, and develop new, scientific techniques and experimental protocols and will be expected to develop and contribute ideas for new research projects.

　　You will hold (or be working towards) a relevant PhD/DPhil in biology, molecular biology or a related science and will have a high level of technical competence in standard molecular and cell biological techniques, including especially cell culture and, for example, western blotting, immunofluorescence, transfection, DNA and RNA isolation.

　　This is a full-time post offered for 14 months in the first instance.

　　All applicants must complete a short application form, upload a CV and supporting statement.

　　The closing date for applications is 12.00 noon on 24 April 2019.

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