招聘簡介：

　　楊柳青博士和林春茹博士來自MD安德森癌癥中心的分子與細(xì)胞腫瘤學(xué)系，他們對長非編碼RNA（lncrnas）在癌癥和遺傳疾病中的功能性作用很感興趣。我們已經(jīng)證明了長非編碼RNA在多種信號途徑中的分子機(jī)制，包括那些調(diào)節(jié)乳腺癌轉(zhuǎn)移和代謝重編程的途徑（Cell 2014，NCB 2016，NCB 2017，Nature Immunol）。在新聞界）實驗室也在研究長非編碼RNA在代謝紊亂中的功能重要性。我們已經(jīng)開發(fā)了crispr/cas9介導(dǎo)的lncrna編輯/敲除/敲入小鼠模型和轉(zhuǎn)基因小鼠模型。我們最新的項目將使用上述小鼠模型研究lncrnas在乳腺癌/胰腺癌/肺癌和代謝紊亂發(fā)展中的功能作用。博士后應(yīng)掌握生物化學(xué)、細(xì)胞生物學(xué)、免疫學(xué)和小鼠遺傳學(xué)的基本技術(shù)。申請者也應(yīng)該是樂于學(xué)習(xí)的獨立思想家。博士后候選人應(yīng)該在三個月內(nèi)加入實驗室。工資將基于NIH PostDoc工資標(biāo)準(zhǔn)。 

　　英文原文：

　　Drs. Liuqing Yang and Chunru Lin, from the Department of Molecular & Cellular Oncology at MD Anderson Cancer Center, are interested in the functional role of long non-coding RNAs (lncRNAs) in cancer and genetic disease. We have demonstrated the molecular mechanisms of long non-coding RNAs in a variety of signaling pathways, including those that regulate breast cancer metastasis and metabolic reprogramming (Cell 2014, NCB 2016, NCB 2017, Nature Immunol. in press). The laboratory is also investigating the functional importance of long noncoding RNAs in metabolic disorders. We have been developed CRISPR/Cas9-mediated lncRNA editing/knockout/knockin mouse models, and transgenic mouse models. Our newest projects will study lncRNAs’ functional roles in the development of breast/pancreatic/lung cancer, and metabolic disorders using the above mentioned mouse models. Postdoc candidates should possess mastery of basic techniques in biochemistry, cell biology, immunology, and mouse genetics. Applicants should also be independent thinkers who are always willing to learn. The postdoc candidates should expect to join the lab in around three months. The salary will be based on the NIH postdoc salary scale.

　　Responsibilities:

　　• Use cutting-edge methods to seek novel therapy targets for human cancers and metabolic disorders

　　• Be responsible for the design and execution of experimental work, data analysis and their written records

　　• Attend and present at internal and international meetings

　　• Be expected to publish data in top scientific journals

　　Job requirements:

　　• PhD in Molecular Biology, Biochemistry or related field

　　• Outstanding publication record

　　• Strong previous experience in biochemistry

　　• Prior experience in RNA biology is preferred.

　　• Prior experience in genetic mouse models is preferred.

　　• Excellent communication with a focus on teamwork is required.

　　Please send a letter of intent, curriculum vitae, names and addresses of three to five references, and a brief summary of past research accomplishments and future research plans to:

　　Chunru Lin, PhD, Assistant Professor

　　The University of Texas MD Anderson Cancer Center

　　Department of Lymphoma/Myeloma

　　1515 Holcombe Blvd, Unit 0429

　　Houston, TX 77030-4009

　　Email: clin2@mdanderson.org

　　MD Anderson Cancer Center is an equal opportunity employer and does not discriminate on the basis of race, color, religion, age, national origin, sex, sexual orientation, gender identity/expression, disability, veteran status, genetic information, or any other basis protected by federal, state, or local laws, unless such distinction is required by law. All positions at The University of Texas MD Anderson Cancer Center are security sensitive and subject to examination of criminal history record information. Smoke-free and drug-free environment.

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