招聘簡介：

　　位于密蘇里州圣路易斯的華盛頓大學醫(yī)學院的克里斯托弗·斯特金博士的實驗室里有一個博士后職位。我們已經(jīng)開發(fā)出新的人類多能干細胞定向分化策略，可以產(chǎn)生胚胎外和胚胎內(nèi)的造血祖細胞。有幾個研究項目可供選擇，都集中在這些hpsc衍生的造血干/祖細胞的翻譯潛能�？赡艿捻椖堪�括從hpsc衍生的過繼免疫療法的發(fā)展，造血發(fā)展的表觀遺傳和轉(zhuǎn)錄后調(diào)控，以及可移植造血人群的特征。

　　申請人將負責管理自己的項目，并在鱘魚實驗室內(nèi)以及與其他當?shù)貓F體進行合作。申請人應(yīng)具有博士或醫(yī)學博士學位，并具有相關(guān)研究經(jīng)驗和出版記錄。良好的英語口頭和書面溝通能力是必不可少的。在造血/免疫學、發(fā)育生物學或細胞生物學方面有很強背景者優(yōu)先，但不需要。以前的生物信息學或小鼠異種移植試驗將是一種資產(chǎn)。

　　英文原文：

　　A postdoctoral position is available in the laboratory of Dr. Christopher Sturgeon, at the Washington University School of Medicine, in St. Louis, MO. We have developed novel human pluripotent stem cell (hPSC) directed differentiation strategies that generate extra-embryonic and intra-embryonic like hematopoietic progenitors. Several research projects are available, all focused on the translational potential of these hPSC-derived hematopoietic stem/progenitor cells. Possible projects range from the development of hPSC-derived adoptive immunotherapies, epigenetic and post-transcriptional regulation of hematopoietic development, and the characterization of engraftable hematopoietic populations.

　　The applicant will be responsible for managing their own projects as well as collaborating both within the Sturgeon laboratory, and with other local groups. Applicants should have a PhD or MD and demonstrated relevant research experience and publication record. Excellent verbal and written English communication skills are essential. A strong background in either hematopoiesis / immunology, developmental biology, or cell biology is preferred, but not required. Previous bioinformatics or murine xenograft assays would be an asset.

　　Interested applicants should send a current CV, statement of research interests, and 2-3 contacts for reference letters, to Christopher Sturgeon (csturgeon@wustl.edu)

　　Representative publications include:

　　1) Sturgeon CM, Ditadi A, Awong G, Kennedy M, Keller G. Wnt Signaling Controls the Specification of Definitive and Primitive Hematopoiesis From Human Pluripotent Stem Cells. Nature Biotechnology. 2014 32(6):554-561

　　2) Ditadi A, Sturgeon CM, Tober J, Awong G, Kennedy M, Phillips A, Ng ES, Stanley E, French DL, Cheng X, Gadue P, Speck N, Elefant AG, Keller G. Human definitive haemogenic endothelium and arterial vascular endothelium represent distinct lineages. Nature Cell Biology. 2015 17(5):580-591

　　3) Creamer JP, Dege C, Ren Q, Ho JTK, Valentine MC, Druley TE, Sturgeon CM*. Human definitive hematopoietic specification from pluripotent stem cells is regulated by mesodermal expression of CDX4. Blood. 2017 129(22):2988-2992.

　　4) Fok WC, Niero ELO, Dege C, Brenner KA, Sturgeon CM*, Batista LFZ*. p53 mediates failure of definitive hematopoiesis in dyskeratosis congenita. Stem Cell Reports. 2017 9(2):409-418

　　5) Ditadi A, Sturgeon CM, Keller G. A view of haematopoietic development from the Petri dish. Nature Reviews Molecular Cellular Biology. 2017 18(1):56-67

　　For more information about our lab research please visit our website (www.sturgeonlab.com).

　　We offer competitive salaries and benefits, please refer to the Human Resources website (http://hr.wustl.edu), and information on being a postdoc at Washington University in St. Louis can be found at http://postdoc.wustl.edu/prospective-postdocs.

　　Diversity and Inclusion are core values at Washington University. Washington University seeks an exceptionally qualified and diverse faculty, staff, students and postdocs; women, minorities, protected veterans, and candidates with disabilities are strongly encouraged to apply.

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