招聘簡介：

　　波士頓大學肺中心博斯曼實驗室正在招募博士后研究員，負責感染相關(guān)免疫學和肺部炎癥的研究項目。

　　急性呼吸窘迫綜合征（ARDS）和膿毒癥是微生物感染的危及生命的并發(fā)癥，免疫系統(tǒng)受到嚴重干擾。在目前缺乏明確治療方案的情況下，ARDS和膿毒癥是全球衛(wèi)生系統(tǒng)面臨的一個巨大問題。我們的實驗室致力于更好地了解這些炎癥性疾病發(fā)病過程中的分子過程。我們實驗室生產(chǎn)的幾種新型轉(zhuǎn)基因小鼠菌株將可用。

　　我們正在尋找積極的博士后研究員，以促進我們的實驗和翻譯研究。特別關(guān)注的領(lǐng)域是涉及炎癥、病原體識別、宿主-病原體相互作用、巨噬細胞、中性粒細胞、細胞因子和相關(guān)信號通路的新基因的作用。這些項目將根據(jù)研究員的個人資格和興趣進行量身定制。例如，可以與申請人討論分子生物學技術(shù)、免疫學方法、生物信息學或手術(shù)小鼠模型的性質(zhì)和范圍。

　　英文原文：

　　The Boston University Pulmonary Center, Bosmann Lab is recruiting Postdoctoral Fellows for projects on infection-associated immunology and lung inflammation.

　　Acute respiratory distress syndrome (ARDS) and sepsis are life-threatening complications of microbial infections with profound disturbances of the immune system. In the current absence of definitive treatment options, ARDS and sepsis represent an enormous problem for health systems worldwide. Our laboratory is dedicated to obtain a better mechanistic understanding of the molecular processes during the pathogenesis of these inflammatory diseases. Several novel transgenic mouse strains generated by our laboratory will be available.

　　We are looking for highly motivated Postdoctoral Fellows to promote our experimental and translational research. Special areas of interest are the role of novel genes involved in inflammation, pathogen recognition, host-pathogen interactions, macrophages, neutrophils, cytokines and related signaling pathways. The projects will be tailored to meet the individual qualifications and interests of the Fellow. For example, the nature and extent of molecular biology techniques, immunology methods, bioinformatics or a focus on surgical mouse models can be discussed with the applicant.

　　The projects will involve a broad spectrum of immunology methods together with massive parallel sequencing (bulk RNA-Seq, single-cell RNA-Seq) including data analysis. Boston University houses a new Single Cell Core Facility. Another area of interest is genome editing by RNA-guided nucleases (e.g. CRISPR-Cas9) in the mouse germline or cell cultures.

　　The Postdoctoral Fellow will have opportunities in designing as well as conducting independent projects. New graduates and experienced researchers with a strong record of publications are welcome to apply. An MD, PhD or equivalent degree in a relevant field is required and a strong background in Immunology and/or Molecular Biology is preferred. The ability in initiating, conducting, evaluating and reporting of research studies is essential. Funds available include slots for US citizens / Resident Aliens on a T32 grant and affiliation to the Immunology Training Program.

　　Further information is available:

　　http://www.bumc.bu.edu/pulmonary/people/faculty/markus-bosmann-m-d/

　　Please send your CV, publication list, transcripts and names of three references to:

　　Markus Bosmann, M.D., Assistant Professor of Medicine, mbosmann@bu.edu

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