招聘簡介:

　　紐約大學醫(yī)學院的Holger Knaut小組尋求高度積極性，注重細節(jié)，熱情的博士學位�；蛘呔哂屑毎�生物學，熒光顯微術(shù)或生物物理學經(jīng)驗的M.D.畢業(yè)生，使用定量成像，遺傳學和計算建模，探索與活體動物背景下形態(tài)發(fā)生過程中細胞行為調(diào)節(jié)有關(guān)的項目。

　　我們小組的目標是破解形態(tài)發(fā)生過程中動態(tài)細胞行為的物理，分子和細胞原理。我們希望揭示這些原理將有助于理解正常的細胞動力學如何促進發(fā)育和體內(nèi)平衡以及為什么擾動會導(dǎo)致缺陷和疾病。

　　我們的實驗室用于理解動態(tài)細胞行為的當前模型是將神經(jīng)元組裝成簇（Lewellis S等人，Journal of Cell Biology。2013），感覺器官的組織運動（Venkiteswaran G等，Cell.2013，Wang J et al。 al.Development Cell.2018）和斑馬魚中冠狀動脈網(wǎng)絡(luò)的形成（Nagelberg D等，Current Biology。2015）。為了詢問這些過程，我們經(jīng)常與其他實驗室合作，使用經(jīng)典遺傳學，基因組工程，高級熒光顯微鏡和計算建模。

　　英文原文：

　　The group of Holger Knaut at NYU School of Medicine seeks highly motivated, detail orientated, and passionate Ph.D. or M.D. graduates with experience in cell biology, fluorescence microscopy or biophysics to explore projects related to the regulation of cellular behaviors during morphogenesis in the context of live animals using quantitative imaging, genetics and computational modeling.

　　The goal of our group is to decipher the physical, molecular and cellular principles underlying dynamic cell behaviors during morphogenesis. We hope that uncovering these principles will provide an understanding of how normal cell dynamics contributes to development and homeostasis and why perturbations cause defects and disease.

　　Current models our lab uses to understand dynamic cell behavior are the assembly of neurons into clusters (Lewellis S et al. Journal of Cell Biology. 2013), the tissue movement of sensory organs (Venkiteswaran G et al. Cell. 2013, Wang J et al. Developmental Cell. 2018) and the formation of the coronary artery network in zebrafish (Nagelberg D et al. Current Biology. 2015). To interrogate these processes we use classical genetics, genome engineering, advanced fluorescence microscopy and computational modeling, often in collaboration with other laboratories.

　　Our group is located in the Skirball Institute of the NYU School of Medicine in midtown Manhattan (New York City). The Skirball Institute is a premier institution for biomedical research. The institute focuses boldly on basic research. It also provides excellent core facilities and a supportive environment for interactions between its labs and the clinical disciplines at NYU Langone Medical Center. With a strong awareness that most medical breakthroughs originate in basic research, the medical center has allocated considerable resources in developing a state-of-the-art, modern, interdisciplinary research unit right in the center of the medical school environment.

　　Candidates should have a recent MD, PhD or MD/PhD degree and a strong background in cell biology, fluorescent microscopy or biophysics. Although not essential, candidates with experience in the use of animal models are encouraged to apply. Please send a cover letter explaining relevant work experience and interests, a CV, and the contact information of three references to Holger Knaut at holger.knaut@med.nyu.edu.

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