招聘簡(jiǎn)介:

　　華盛頓大學(xué)醫(yī)學(xué)院內(nèi)分泌、代謝和脂質(zhì)研究部的Irfan Lodhi博士的實(shí)驗(yàn)室有一個(gè)博士后職位。Lodhi實(shí)驗(yàn)室使用尖端技術(shù)，如Crispr/CAS9、下一代測(cè)序、脂質(zhì)組學(xué)和蛋白質(zhì)組學(xué)。實(shí)驗(yàn)室的總體目標(biāo)是了解脂質(zhì)代謝途徑在調(diào)節(jié)能量平衡中的作用。我們特別感興趣的是多功能的細(xì)胞器稱為過氧化物酶體如何將脂質(zhì)輸送到離散的亞細(xì)胞間室，從而影響新陳代謝。在這一研究中，我們最近的研究表明過氧化物酶體衍生的脂質(zhì)調(diào)節(jié)線粒體動(dòng)力學(xué)和棕色脂肪介導(dǎo)的熱生成（參見Park等人2019，臨床研究雜志129（2）：694-711）。有關(guān)更多信息和完整的出版物列表，請(qǐng)?jiān)L問我們的實(shí)驗(yàn)室網(wǎng)站（www.lodilab.org）。

　　申請(qǐng)人必須擁有生理學(xué)、細(xì)胞生物學(xué)、生物化學(xué)或相關(guān)領(lǐng)域的博士學(xué)位，并具有豐富的分子生物學(xué)經(jīng)驗(yàn)，這一點(diǎn)在知名期刊上有明顯的體現(xiàn)。有鼠標(biāo)操作和手術(shù)經(jīng)驗(yàn)是可取的，但不是必需的。有學(xué)習(xí)這些技巧的意愿者優(yōu)先。在獨(dú)立的分析思維，實(shí)驗(yàn)設(shè)計(jì)，故障排除，以及與實(shí)驗(yàn)室工作人員和調(diào)查人員有效溝通的能力方面的技能是非常需要的。邀請(qǐng)合格的候選人與Irfan Lodhi博士（ilodhi@wustl.edu）聯(lián)系，并提供簡(jiǎn)歷和三名推薦人的姓名。

　　英文原文：

　　A postdoctoral position is available in the laboratory of Dr. Irfan Lodhi in the Division of Endocrinology, Metabolism & Lipid Research at Washington University School of Medicine. The Lodhi lab uses cutting-edge techniques such as CRISPR/Cas9, next-generation sequencing, lipidomics and proteomics. The overall goal of the lab is to understand the role of lipid metabolism pathways in the regulation of energy homeostasis. We are particularly interested in how the multifunctional organelles called peroxisomes channel lipids to discrete subcellular compartments to influence metabolism. In this line of investigation, our recent studies suggest that peroxisome-derived lipids regulate mitochondrial dynamics and brown fat-mediated thermogenesis (see Park et al. 2019, Journal of Clinical Investigation 129(2):694-711). For more information and a complete list of publications, please visit our lab website (www.LodhiLab.org).

　　The candidate must have a PhD in physiology, cell biology, biochemistry or a related field with strong experience in molecular biology evident by publication in reputable journals. Experience in mouse handling and surgery is desirable, but not required. Willingness to learn these techniques is preferred. Skills in independent analytical thinking, experimental design, troubleshooting, and the ability to effectively communicate with the laboratory staff and investigators are highly desired. Qualified candidates are invited to contact Dr. Irfan Lodhi (ilodhi@wustl.edu) with CV and names of three references.

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