招聘簡介：

　　需要：一個結(jié)合病毒基因治療和DNA條形碼納米粒的博士后

　　佐治亞理工學(xué)院和埃默里醫(yī)學(xué)院的達(dá)爾曼實(shí)驗室（dahlman lab.org）開創(chuàng)性地將DNA條形碼納米粒子用于sirna、mrna和cas9療法。我們第一次可以評估數(shù)千種不同的納米顆粒如何在動物體內(nèi)傳遞RNA和DNA藥物，而不是在細(xì)胞培養(yǎng)中評估它們。自2016年成立全新實(shí)驗室以來，已在JACS、PNAS、Advanced Materials、ACS Nano等期刊上發(fā)表了8篇DNA條形碼/基因編輯/基因治療論文。目前，該實(shí)驗室已發(fā)展到約15人，細(xì)胞、Nano自然、美國科學(xué)院等機(jī)構(gòu)正在審查論文。在過去的2.5年中，實(shí)驗室已經(jīng)生成了數(shù)十萬個體內(nèi)基因治療數(shù)據(jù)點(diǎn)；這種數(shù)據(jù)生成規(guī)模對于納米醫(yī)學(xué)來說是新的。例如，下面的heatmap描述了單個實(shí)驗產(chǎn)生的大約8000個體內(nèi)藥物傳遞數(shù)據(jù)點(diǎn)。利用生物信息學(xué)管道，這些數(shù)據(jù)被用于開發(fā)新的CAS9療法。

　　英文原文：

　　Needed: A post-doc to combine viral gene therapy with DNA barcoded nanoparticles

　　The Dahlman Lab at Georgia Tech and Emory School of Medicine (dahlmanlab.org) is pioneering the use of DNA barcoded nanoparticles for siRNA, mRNA, and Cas9 therapies. For the first time, we can evaluate how thousands of different nanoparticles deliver RNA and DNA drugs in animals, instead of evaluating them in cell culture. Since starting as a brand-new lab in 2016, 8 DNA barcoding / gene editing / gene therapy papers in JACS, PNAS, Advanced Materials, ACS Nano, and other journals have been published. With the lab now having grown to ~15 people, papers are currently under review at Cell, Nature Nano, Scientific American, and others. In the last 2.5 years, the lab has generated hundreds of thousands of in vivo gene therapy data points; this scale of data generation is new to nanomedicine. For example, the heatmap below depicts ~8,000 in vivo drug delivery data points generated from a single experiment. Using bioinformatics pipelines, these data are used to develop new Cas9 therapies.

　　We are hiring a post-doc with a background in capsid shuffling and AAV libraries. This post-doc will work on a brand new, highly translational, project. The first goal will be to quickly generate several high-quality publications. Training will be provided in efficient experimental design, aimed at maximum publishable data generation/unit of effort. Most recently, a former Ph.D. student in the lab published and submitted 14 papers (PNAS, JACS, etc.) in their first 2.5 years. Furthermore, this position will provide experience in Biotechnology startup creation and developing relationships with leading industry partners interested in translating projects to direct clinical applications.

　　This is a unique opportunity. First, you will be a member of an exciting, diverse, and interdisciplinary group. Second, you will learn about nanoparticle DNA barcoding, which combines high throughput chemistry, nanoparticle characterization, RNA therapies, Cas9, and genomics. Third, you will be working in a cutting-edge field (gene therapies). Finally, the Georgia Tech and Emory Medical School Department of Biomedical Engineering is ranked #3 and #2 for undergraduate and graduate studies, respectively. Located in Atlanta, a thriving city with major cultural, professional, and athletic institutions, the standard salary goes much farther here than in New York, Boston, and San Francisco. Nicknamed the ‘city in a forest,’ Atlanta offers great food, music, breweries, hiking, biking, weather, and other attractions. Finally, the Dahlman Lab is a supportive and inclusive environment; we care deeply about all our lab members, independent of their background, experiences, preferences, or beliefs.

　　Email a CV to james.dahlman@bme.gatech.edu.* Due to the time sensitivity of this project, applicants for the position will be evaluated in the order applications are received.*

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