招聘簡介：

　　在許多合作項目中開放博士后職位以研究ApoA-I結(jié)合蛋白的結(jié)構(gòu)功能和生物學(xué)（AIBP;請參考Nature 2013,498：118-22; Cell Rep 2018,23（9）：2667-77; JCI Insight 2018,3（16）pii：120519; J Lipid Res。2018,59（5）：854-863），該蛋白質(zhì)選擇性調(diào)節(jié)發(fā)炎和膽固醇過多細胞中的脂筏。加利福尼亞大學(xué)圣地亞哥分校Yury Miller實驗室的研究是膽固醇代謝/脂筏，血管和神經(jīng)炎癥，神經(jīng)性疼痛和神經(jīng)變性的交叉點。一個項目是與Robert Rissman的實驗室合作，使用細胞和小鼠模型研究AIBP在神經(jīng)炎癥和神經(jīng)變性中的保護作用。另一個項目與Irina Kufareva實驗室合作，重點關(guān)注AIBP-TLR4和AIBP-載脂蛋白相互作用的結(jié)構(gòu)決定因素。成功的候選人將是最近的博士研究生（0-1歲），具有強大的出版記錄和在分子生物學(xué)，神經(jīng)元/神經(jīng)膠質(zhì)細胞生物學(xué)，高分辨率成像和/或神經(jīng)變性小鼠模型方面的專業(yè)知識。這些研究員將成為一個充滿活力的研究團體的一部分，結(jié)合參與脂質(zhì)異常，動脈粥樣硬化，神經(jīng)炎癥，神經(jīng)性疼痛，阿爾茨海默氏癥和其他神經(jīng)退行性疾病的機制的見解，重點關(guān)注科學(xué)發(fā)現(xiàn)轉(zhuǎn)化為臨床。請將一封求職信以及簡歷和3名裁判的姓名發(fā)送給Yury Miller，yumiller @ usdd.edu。

　　英文原文：

　　Open postdoctoral positions in a number of collaborative projects to study structure-function and biology of ApoA-I Binding Protein (AIBP; please refer to Nature 2013, 498:118-22; Cell Rep 2018, 23(9):2667-77; JCI Insight 2018, 3(16) pii: 120519; J Lipid Res. 2018, 59(5):854-863), the protein that selectively regulates lipid rafts in inflamed and cholesterol-overloaded cells. The research in Yury Miller’s laboratory at the University of California, San Diego is at the intersection of cholesterol metabolism/lipid rafts, vascular and neuro inflammation, neuropathic pain and neurodegeneration. One project is a collaboration with Robert Rissman’s lab to study protective role of AIBP in neuroinflammation and neurodegeneration, using cellular and mouse models. Another project, in collaboration with Irina Kufareva’s lab, focuses on structural determinants of AIBP-TLR4 and AIBP-apolipoprotein interactions. The successful candidate will be a recent PhD graduate (0-1 years) with a strong publication record and demonstrated expertise in molecular biology, neuronal/glial cell biology, high-resolution imaging and/or mouse models of neurodegeneration. The fellows will be part of a vibrant research community combining insights from mechanisms involved in the development of lipid abnormalities, atherosclerosis, neuroinflammation, neuropathic pain, Alzheimer’s and other neurodegenerative diseases, with a strong focus on translation of scientific discoveries into clinic. Please send a cover letter together with the CV and names of 3 referees to Yury Miller, yumiller@ucsd.edu .

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