招聘簡(jiǎn)介：

　　·邁阿密大學(xué)

　　·地點(diǎn)：佛羅里達(dá)州邁阿密

　　·工作編號(hào)：7057026

　　·入賬日期：2019年4月17日

　　·申請(qǐng)截止日期：開(kāi)放至填寫(xiě)

　　職位描述

　　邁阿密大學(xué)米勒醫(yī)學(xué)院西爾維斯特綜合癌癥中心的莫里博士實(shí)驗(yàn)室有兩個(gè)博士后研究員職位。Morey實(shí)驗(yàn)室專(zhuān)注于表觀(guān)遺傳學(xué)機(jī)制，控制癌癥的發(fā)生和發(fā)展，以及干細(xì)胞分化。

　　我們實(shí)驗(yàn)室的前期工作表明，多梳組（PCG）復(fù)合物的結(jié)構(gòu)有助于調(diào)節(jié)干細(xì)胞命運(yùn)的決定（Morey等人細(xì)胞干細(xì)胞，2012；Morey等人Cell Reports，2013年；Morey等人細(xì)胞干細(xì)胞，2015年）。最近，我們發(fā)現(xiàn)PCG復(fù)合物被招募到多種癌癥的活性增強(qiáng)劑中，突出了PCG復(fù)合物在調(diào)節(jié)癌癥中的致癌轉(zhuǎn)錄程序方面的功能探索不足（Chan等人Nature Comm，2018；Chan和Morey，生物化學(xué)趨勢(shì)，出版）。

　　英文原文：

　　·         University of Miami

　　·         Location: Miami, FL

　　·         Job Number: 7057026

　　·         Posting Date: Apr 17, 2019

　　·         Application Deadline: Open Until Filled

　　Job Description

　　Two postdoctoral fellow positions are available in Dr. Morey’s lab at Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine. The Morey lab focuses on the epigenetic mechanisms that control cancer initiation and progression, and stem cell differentiation.

　　Previous work in our lab have shown that the architecture of Polycomb-group (PcG) complexes is instrumental in regulating stem cell fate decisions (Morey et al. Cell Stem Cell, 2012; Morey et al. Cell Reports, 2013; Morey et al. Cell Stem Cell, 2015). Recently, we have discovered that PcG complexes are recruited to active enhancers in multiple cancers, highlighting an under-explored function of PcG complexes in regulating oncogenic transcriptional programs in cancer (Chan et al. Nature Comm, 2018; Chan and Morey, Trends in Biochemical Sciences, in press).

　　Two Postdoctoral fellow positions:

　　Our research program aims to characterize the PcG-mediated mechanisms in multiple cancer types, including breast cancer (position 1), and in human pluripotent stem cell differentiation (position 2). The projects will employ genetic, biochemical and genomic approaches including 3D chromatin architecture assays (HiC and HiChIP) and CRISPR/Cas9 screens, as well as standard genome-wide assays (ChIP- RNA- ATAC-seq). Experiments will be performed using both cell culture (cancer cells and human embryonic stem cells) and in vivo models (xenografts and PDX models).

　　Successful candidates will have earned a Ph.D. in genetics, molecular biology, cellular biology, or related fields and demonstrated the ability to complete research projects independently. Expertise in epigenetics in any model system will greatly strengthen the application. Experience with computational analysis of genomic data is a plus but is not required.

　　For additional information please visit our webpages:

　　www.moreylab.com

　　www. sylvester.org

　　Interested candidates are invited to contact Dr. Lluis Morey (lmorey@med.miami.edu ) with CV and names of two references.

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