招聘簡介：

　　衛(wèi)生與公眾服務(wù)部

　　國家衛(wèi)生研究院（NIH）

　　國家癌癥研究所（NCI）

　　癌癥治療與診斷司

　　影響新型抗癌藥物的發(fā)展

　　特工在國家癌癥研究所接受訓(xùn)練

　　職位描述：

　　NCI癌癥治療和診斷部門正在邀請有資格的申請者擔(dān)任發(fā)展治療領(lǐng)域的博士后研究職位。成功的申請人將在一個多學(xué)科項目中承擔(dān)主要的科學(xué)部分，該項目旨在調(diào)查活性氧（ROS）在正常和病理改變組織中的作用，以及由NADPH氧化酶（NOXS）和雙氧化酶2（Duox2）介導(dǎo)的異常信號在炎癥和腫瘤疾病中的作用。作為這項高度合作努力的重要組成部分，博士后研究人員將在與NCI癌癥研究中心高級臨床前研究中心（CAPR）密切互動和指導(dǎo)下開展其工作的重要部分；CAPR中的科學(xué)家是開發(fā)和使用各種組織的專家。f基因工程疾病模型，以了解疾病的機(jī)制。博士后研究員將重點關(guān)注的具體項目包括了解細(xì)胞氧化損傷在胃腸道炎癥和癌變的開始/進(jìn)展中的作用。

　　在完成該項目的過程中，該博士后研究員將有機(jī)會接觸并接受多種最先進(jìn)的實驗資源和技術(shù)的培訓(xùn)，如通過各種組織學(xué)/組織化學(xué)程序分析臨床前組織標(biāo)本，開發(fā)基因工程小鼠模型。ELS適用于適用疾�。ㄈ缫认侔┖徒Y(jié)直腸癌），處理患者來源的異種移植模型，應(yīng)用小動物成像工具監(jiān)測疾病進(jìn)展和治療反應(yīng)，以及廣泛收集用于分子和遺傳分析的其他工具。這位科學(xué)家還將致力于優(yōu)化現(xiàn)有的體內(nèi)疾病模型，以期隨后將其應(yīng)用于信息化的臨床前藥物開發(fā)。他/她還將能夠獲得多個研究資源和科學(xué)核心設(shè)施，以推進(jìn)該項目，預(yù)計將通過同行評審期刊上的一份或多份高影響力出版物完成這項研究。這項任命將涉及到大量的多學(xué)科互動，需要在幾個合作伙伴和科學(xué)支助核心之間經(jīng)常協(xié)調(diào)努力。

　　英文原文：

　　 Department of Health and Human Services (HHS)

　　National Institutes of Health (NIH)

　　National Cancer Institute (NCI)

　　Division of Cancer Treatment and Diagnosis (DCTD)

　　MAKE AN IMPACT ON THE DEVELOPMENT OF NOVEL ANTICANCER

　　AGENTS COME TRAIN AT THE NATIONAL CANCER INSTITUTE

　　Position Description:

　　Division of Cancer Treatment and Diagnosis, NCI is inviting qualified applications for a postdoctoral research position in the area of developmental therapeutics. The successful applicant will assume a major scientific part in a multidisciplinary project aimed at investigating the role of reactive oxygen species (ROS) generation in normal and pathologically altered tissues, and the role of aberrant signaling mediated by NADPH oxidases (NOXs) and dual oxidase 2 (Duox2) in inflammatory and oncologic diseases. As an essential part of this highly collaborative effort, the postdoctoral researcher will conduct a significant part of his/her work in close interaction with, and under a guidance of, the Center for Advanced Preclinical Research (CAPR) of the Center for Cancer Research, NCI; scientists in CAPR are experts in developing and employing a variety of genetically engineered disease models to understand mechanisms of disease. The specific project that the postdoctoral fellow will focus on involves understanding the role of cellular oxidative damage in the initiation/progression of gastrointestinal inflammation and carcinogenesis.

　　In the course of completing the proposed project, this postdoctoral researcher will have an opportunity to access and receive training in multiple state-of-the-art experimental resources and technologies, such as analyzing pre-clinical tissue specimens by various histology/histochemistry procedures, development of genetically engineered murine models for applicable diseases (e.g. pancreatic and colorectal cancer), handling patient-derived xenograft models, applying small animal imaging tools to monitor disease progression and therapeutic responses, as well as a broad collection of other tools for molecular and genetic analyses. This scientist will also work on optimizing the available disease in vivo models with a goal of subsequently applying them for informative preclinical drug development. He/she will also be able to access multiple research resources and scientific core facilities to advance the project and is anticipated to complete this study with one or more high-impact publications in peer review journals. This appointment will involve a substantial level of multi-disciplinary interaction and will require frequent coordination of efforts among several collaborating partners and scientific support cores.

　　Qualifications:

　　Ideal candidates will have a PhD degree in biochemistry, molecular/tumor biology, or related disciplines and preferably prior experience in developing of genetically and biologically engineered disease animal models for basic and translational research. Communication skills and the ability to collect, analyze, compile and communicate complex scientific data both verbally and in writing is an essential prerequisite for this position. Salary is commensurate with research experience and accomplishments.

　　To Apply:

　　Please send an application with resume/CV and support documentation to: Monika Sarna, administrative officer, Office of the Director, Division of Cancer Treatment and Diagnosis, Room 3A44, Building 31, 31 Center Drive, National Cancer Institute, NIH, Bethesda, MD 20892; msarna@mail.nih.gov

　　This position is subject to a background investigation

　　The NIH is dedicated to building a diverse community in its training and employment programs.

　　DHHS, NIH AND NCI ARE EQUAL OPPORTUNITY EMPLOYERS

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