招聘簡介：

　　在美國加利福尼亞拉荷亞斯克里普斯研究所的Encarada實(shí)驗(yàn)室，可以獲得一個(gè)博士后職位，該職位涉及神經(jīng)變性、衰老和細(xì)胞內(nèi)轉(zhuǎn)運(yùn)。我們的實(shí)驗(yàn)室有興趣描述神經(jīng)元中分子運(yùn)動(dòng)驅(qū)動(dòng)轉(zhuǎn)運(yùn)的調(diào)節(jié)機(jī)制，缺陷轉(zhuǎn)運(yùn)在神經(jīng)變性和衰老中的作用，以及涉及朊病毒疾病、阿爾茨海默病、轉(zhuǎn)甲狀腺素淀粉樣蛋白和tauopathie的錯(cuò)誤折疊蛋白的傳播機(jī)制。我們還研究了神經(jīng)退行性變中液-液相分離的形成機(jī)制，包括我們?yōu)楦鞣N疾病生成的神經(jīng)元模型。通過將細(xì)胞生物學(xué)、遺傳學(xué)、生物化學(xué)和高分辨率定量光和電鏡的結(jié)合應(yīng)用于各種模型系統(tǒng)（包括哺乳動(dòng)物神經(jīng)元、小鼠和線蟲）的研究，您將有機(jī)會在斯克里普斯研究所的一流知識環(huán)境中進(jìn)行研究。

　　斯克里普斯研究所位于美麗的加州拉荷亞，是世界上最大的、私營的、非營利的研究機(jī)構(gòu)之一，站在基礎(chǔ)生物醫(yī)學(xué)和轉(zhuǎn)化科學(xué)的前沿。該研究所提供世界一流的資源和合作、協(xié)作的環(huán)境，促進(jìn)了這里的杰出發(fā)現(xiàn)。

　　英文原文：

　　A postdoctoral position is available in the Encalada Laboratory at The Scripps Research Institute in La Jolla, California, USA, in the areas of neurodegeneration, aging, and intracellular transport. Our lab is interested in characterizing the mechanisms of regulation of molecular motor-driven transport in neurons, the role that defective transport plays in neurodegeneration and aging, and the mechanisms of spreading of misfolded proteins involved in prion diseases, Alzheimer’s disease, transthyretin amyloidoses, and tauopathies. We also investigate the mechanisms of formation of liquid-liquid phase separations in neurodegeneration including in neuronal models that we have generated for various diseases. You will have the opportunity to do research in a superb intellectual setting at Scripps Research, by applying a combination of cell biology, genetics, biochemistry, and high-resolution quantitative light and EM microscopy to your research in various model systems including mammalian neurons, mice, and C. elegans.

　　The Scripps Research Institute is located in beautiful La Jolla, California, and is one of the world’s largest, private, non-profit research organizations that stands at the forefront of basic biomedical and translational science. The institute provides world-class resources and a cooperative, collaborative environment, which promotes the outstanding discoveries made here.

　　REQUIREMENTS:

　　1.    You are about to complete your PhD or have completed your PhD within the last year in cell biology, genetics, neurobiology, molecular biology, biophysics, or related field.

　　2.    Highly motivated, independent, with outstanding written and oral communication skills, and with peer-reviewed publications.

　　3.    Research experience with cell biology and light or super-resolution microscopy is highly desirable.

　　Interested candidates please send a CV with a list of publications, a brief statement of your previous research expertise, your postdoctoral research interests, and the contact information of three referees to Sandra Encalada at encalada@scripps.edu. For more information also please consult our website at http://www.scripps.edu/encalada/encalada/HOME.html

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