招聘簡介：

　　在多個合作項目中開設(shè)博士后職位，研究apoa-i結(jié)合蛋白（aibp；請參閱《自然》2013，498:118-22；細胞報告2018，23（9）：2667-77；JCI Insight 2018，3（16）PII:120519；J Lipid Res.2018，59（5）：854-863），選擇性調(diào)節(jié)炎癥和炎癥中脂質(zhì)筏的蛋白質(zhì)。膽固醇超負荷細胞。加州大學圣地亞哥分校尤里·米勒實驗室的研究是膽固醇代謝/脂質(zhì)筏、血管和神經(jīng)炎癥、神經(jīng)性疼痛和神經(jīng)變性的交叉點。一個項目是與Robert Rissman的實驗室合作，使用細胞和小鼠模型研究AIBP在神經(jīng)炎癥和神經(jīng)變性中的保護作用。另一個項目是與伊琳娜·庫法列娃的實驗室合作，重點研究AIBP-TLR4和AIBP載脂蛋白相互作用的結(jié)構(gòu)決定因素。成功的候選人將是一個最近的博士研究生（0-1年），具有很強的出版記錄，并在分子生物學、神經(jīng)元/膠質(zhì)細胞生物學、高分辨率成像和/或神經(jīng)退行性變小鼠模型方面表現(xiàn)出專業(yè)知識。這些研究人員將是一個充滿活力的研究團體的一部分，他們將從脂質(zhì)異常、動脈粥樣硬化、神經(jīng)炎癥、神經(jīng)性疼痛、阿爾茨海默氏癥和其他神經(jīng)退行性疾病的發(fā)展機制中獲得見解，并將重點放在將科學發(fā)現(xiàn)轉(zhuǎn)化為臨床上。請將求職信連同簡歷和3名裁判員的姓名寄給yury miller，yumiller@ucsd.edu。

　　英文原文：

　　Open postdoctoral positions in a number of collaborative projects to study structure-function and biology of ApoA-I Binding Protein (AIBP; please refer to Nature 2013, 498:118-22; Cell Rep 2018, 23(9):2667-77; JCI Insight 2018, 3(16) pii: 120519; J Lipid Res. 2018, 59(5):854-863), the protein that selectively regulates lipid rafts in inflamed and cholesterol-overloaded cells. The research in Yury Miller’s laboratory at the University of California, San Diego is at the intersection of cholesterol metabolism/lipid rafts, vascular and neuro inflammation, neuropathic pain and neurodegeneration. One project is a collaboration with Robert Rissman’s lab to study protective role of AIBP in neuroinflammation and neurodegeneration, using cellular and mouse models. Another project, in collaboration with Irina Kufareva’s lab, focuses on structural determinants of AIBP-TLR4 and AIBP-apolipoprotein interactions. The successful candidate will be a recent PhD graduate (0-1 years) with a strong publication record and demonstrated expertise in molecular biology, neuronal/glial cell biology, high-resolution imaging and/or mouse models of neurodegeneration. The fellows will be part of a vibrant research community combining insights from mechanisms involved in the development of lipid abnormalities, atherosclerosis, neuroinflammation, neuropathic pain, Alzheimer’s and other neurodegenerative diseases, with a strong focus on translation of scientific discoveries into clinic. Please send a cover letter together with the CV and names of 3 referees to Yury Miller, yumiller@ucsd.edu.

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