招聘簡介：

　　職位：博士后培訓(xùn)研究員

　　地點(diǎn)：倫敦米德蘭路弗朗西斯·克里克學(xué)院

　　合同：固定期限，4年

　　充分的時間

　　工資：與福利競爭，取決于技能和經(jīng)驗(yàn)

　　空缺ID:10708

　　總結(jié)

　　在世界級的Francis Crick研究所，在由Charles Swanton教授領(lǐng)導(dǎo)的癌癥進(jìn)化和基因組不穩(wěn)定實(shí)驗(yàn)室，我們正在尋找一位雄心勃勃、積極進(jìn)取的濕實(shí)驗(yàn)室科學(xué)家，他有用老鼠模型模擬癌癥的背景。這一博士后職位將由Francis Crick研究所、ERC和NC3RS資助。該職位將涉及研究基因工程小鼠模型中的腫瘤演變、癌癥免疫反應(yīng)和耐藥性發(fā)展。這項(xiàng)工作將基于正在癌癥進(jìn)化和基因組不穩(wěn)定實(shí)驗(yàn)室進(jìn)行的tracerx研究的結(jié)果，并將涉及最前沿的研究和技術(shù)，如成像大規(guī)模細(xì)胞術(shù)和單細(xì)胞測序。候選人應(yīng)具有癌癥生物學(xué)和遺傳學(xué)方面的深厚背景，具有良好的溝通和組織能力，并在相關(guān)領(lǐng)域獲得博士學(xué)位（或處于完成的最后階段）。

　　英文原文：

　　 Job title: Postdoctoral Training Fellow

　　Location: The Francis Crick Institute, Midland Road, London

　　Contract: Fixed-term, 4 years

　　Full time

　　Salary: Competitive with benefits, subject to skills and experience

　　Vacancy ID: 10708

　　Summary

　　At the world class Francis Crick Institute, in the Cancer Evolution and Genome Instability Laboratory headed by Professor Charles Swanton, we are looking for an ambitious, highly motivated wet-lab scientist with a background in modelling cancer using mouse models. This post-doctoral position will be funded by the Francis Crick Institute, the ERC, and the NC3Rs. The position will involve studying tumour evolution, cancer immune responses and resistance development in genetically engineered mouse models. This work will be based on findings from the TRACERx study that is ongoing in the Cancer Evolution and Genome Instability laboratory, and will involve cutting edge research and techniques such as imaging mass cytometry and single cell sequencing. The candidate should have a strong background in cancer biology and genetics, have good communication and organizational skills, and a PhD in a relevant area (or be at the final stages of completion).

　　For more information please visit: https://www.crick.ac.uk/research/labs/charles-swanton.

　　Project scope

　　Lung cancer is the leading cause of cancer related deaths worldwide and fewer than 20% of all patients with lung cancer are alive 5 years after diagnosis. To improve patient outcomes, we need high-quality models to develop new treatment strategies. Although genetically engineered mouse models (GEMMs) have led to important findings in the past, current GEMMs do not fully recapitulate the heterogeneity observed in human tumours and consequently are not ideal for modelilng resistance development or the immune response to cancer.

　　Advances in sequencing technology have facilitated in-depth genomic studies of tumour evolution. Exome sequencing on spatially separated samples demonstrated the full extent of intratumour heterogeneity in many cancer types. A study in the Cancer Evolution and Genome Instability Laboratory, Tracking Non-Small-Cell Lung Cancer Evolution through Therapy (TRACERx), aims to enrol 842 patients, from whom samples are obtained for high-depth, multiregion whole-exome sequencing of spatially separated tumour biopsies.

　　In these patients, APOBEC mutation signatures were dominant in 15% of patients, and the number of subclonal mutations significantly correlated with APOBEC signatures. Ongoing chromosomal instability (CIN) was found as a second underlying cause of intratumoural heterogeneity, and was linked to poor outcome in the TRACERx dataset. It was also discovered that human HLA loss of heterozygosity (LOH) occurs in 40% of early stage non-small cell lung cancers (NSCLCs), suggesting that HLA LOH may represent an important immune escape mechanism. We aim to model these events alone and in combination, to generate tractable animal tumour evolution models to study clone fitness, immune evasion and the role of subclonal driver events.

　　Postdoctoral Training Fellows are expected to lead their own projects, contribute to other projects on a collaborative basis (both in the lab and with external collaborators) and guide PhD students in their research. The ability to work in a team is essential.

　　About us

　　The Francis Crick Institute is a biomedical discovery institute dedicated to understanding the fundamental biology underlying health and disease. Its work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections, and neurodegenerative diseases.

　　An independent organisation, its founding partners are the Medical Research Council (MRC), Cancer Research UK, Wellcome, UCL (University College London), Imperial College London and King’s College London.

　　The Crick was formed in 2015, and in 2016 it moved into a new state-of-the-art building in central London which brings together 1500 scientists and support staff working collaboratively across disciplines, making it the biggest biomedical research facility under in one building in Europe.

　　The Francis Crick Institute will be world-class with a strong national role. Its distinctive vision for excellence includes commitments to collaboration; developing emerging talent and exporting it the rest of the UK; public engagement; and helping turn discoveries into treatments as quickly as possible to improve lives and strengthen the economy.

　　·         If you are interested in applying for this role, please apply via our website.

　　·         The closing date for applications is 28 May 2019 at 23:30.

　　·         All offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom.

　　Key words

　　Please complete this section with key words and terms that people may enter into a search engine when they are job hunting. This will help us to make your advert more visible to the target market, for example:

　　Example

　　·         Cancer biology

　　·         Mammalian development

　　·         Mouse genetics

　　·         Flow Cytometry

　　·         Image Mass Cytometry

　　·         Single Cell Sequencing

　　·         Lung Cancer

　　·         Immunology

為防止簡歷投遞丟失請抄送一份至：boshijob@126.com（郵件標(biāo)題格式：應(yīng)聘職位名稱+姓名+學(xué)歷+專業(yè)+中國博士人才網(wǎng)）