招聘簡介：

　　在密蘇里州圣路易斯市華盛頓大學(xué)醫(yī)學(xué)院的斯蒂芬·歐博士的實(shí)驗(yàn)室里，可以找到一個(gè)博士后職位。

　　我們的首要目標(biāo)是破譯驅(qū)動血液學(xué)惡性腫瘤發(fā)生、發(fā)展和進(jìn)展的基本機(jī)制。我們研究骨髓增生性腫瘤（MPN），這是一種克隆性疾病，典型的遺傳改變激活JAK-STAT信號。我們利用創(chuàng)新的單細(xì)胞技術(shù)，包括大規(guī)模細(xì)胞術(shù)（cytof）來詢問MPN中失調(diào)的細(xì)胞因子信號網(wǎng)絡(luò)。潛在的項(xiàng)目也可能利用最近獲得的超離子成像系統(tǒng)，將高維單細(xì)胞分析與空間定位結(jié)合起來。

　　我們利用人類患者樣本和小鼠模型來詢問MPN發(fā)病機(jī)制中改變的信號通路。實(shí)驗(yàn)室的一個(gè)重要研究領(lǐng)域是利用遺傳模型來了解炎癥細(xì)胞因子信號在多發(fā)性硬化癥中的作用。第二個(gè)感興趣的領(lǐng)域是下一代測序技術(shù)的應(yīng)用，以描述MPN的基因組復(fù)雜性和克隆進(jìn)化。我們還利用病人源性ipscs和crispr位點(diǎn)定向基因編輯來模擬人類mpn發(fā)病機(jī)制。長期目標(biāo)是整合這些方法，使表型與潛在基因型相聯(lián)系。最后，我們試圖將這項(xiàng)工作轉(zhuǎn)化為改進(jìn)的治療MPN患者。

　　鼓勵(lì)對癌癥生物學(xué)、信號轉(zhuǎn)導(dǎo)、基因組學(xué)、免疫學(xué)、造血、白血病和/或干細(xì)胞感興趣的申請人申請。

　　英文原文：

　　A postdoctoral position is available in the laboratory of Dr. Stephen Oh at Washington University School of Medicine in St. Louis, MO.

　　Our overarching objective is to decipher fundamental mechanisms that drive the initiation, development, and progression of hematologic malignancies. We study myeloproliferative neoplasms (MPNs), which are clonal disorders typified by genetic alterations that activate JAK-STAT signaling.  We utilize innovative single cell technologies including mass cytometry (CyTOF) to interrogate dysregulated cytokine signaling networks in MPNs. Potential projects may also utilize a recently acquired Hyperion Imaging System that couples high dimensional single cell analysis with spatial localization.

　　We utilize human patient samples as well as mouse models to interrogate altered signaling pathways in MPN pathogenesis. A major area of interest in the lab is to utilize genetic models to understand the role of inflammatory cytokine signaling in MPNs. A second area of interest is the application of next generation sequencing technologies to delineate genomic complexity and clonal evolution in MPNs. We also utilize patient-derived iPSCs and CRISPR site-directed gene editing to model human MPN pathogenesis. The long-term objective is to integrate these approaches so that phenotype can be connected to underlying genotype. Ultimately, we seek to translate this work into improved therapies for MPN patients.

　　Applicants interested in cancer biology, signal transduction, genomics, immunology, hematopoiesis, leukemia, and/or stem cells are encouraged to apply.

　　Please see the following links for additional information:

　　http://www.ohlab.org

　　http://hematology.wustl.edu/people/faculty/Oh/Oh_Bio.html

　　Funding through a NIH T32 training grant is available for eligible candidates.

　　Qualifications:

　　Applicants must have a Ph.D. and/or M.D. degree and a strong background in cell and molecular biology. Prior experience with flow cytometry, bioinformatics, genomics, and/or mouse models is highly desirable. Strong written and verbal communications skills are essential.

　　Materials:

　　Please send an inquiry and C.V. with list of references to Dr. Oh at stoh@wustl.edu.

為防止簡歷投遞丟失請抄送一份至：boshijob@126.com（郵件標(biāo)題格式：應(yīng)聘職位名稱+姓名+學(xué)歷+專業(yè)+中國博士人才網(wǎng)）