招聘簡(jiǎn)介：

　　病毒學(xué)/細(xì)胞生物學(xué)博士后職位

　　在NIH資助的研究項(xiàng)目上有博士后職位，研究微管相關(guān)和微管調(diào)節(jié)蛋白的功能及其在納格瓦伊病毒感染中的作用。Naghavi博士是芝加哥西北大學(xué)Feinberg醫(yī)學(xué)院微生物學(xué)免疫學(xué)系的副教授。范伯格醫(yī)學(xué)院位于芝加哥市中心。有關(guān)Naghavi實(shí)驗(yàn)室的更多信息，請(qǐng)?jiān)L問http://labs.feinberg.westernest.edu/naghavi。/

　　我們以前的研究已經(jīng)確定了HIV-1如何控制微管行為以促進(jìn)感染，以及宿主因素。這包括微管運(yùn)動(dòng)相關(guān)的銜接蛋白，以及控制穩(wěn)定微管絲形成和促進(jìn)HIV-1感染的特殊微管加末端跟蹤蛋白（稱為+Tips）。項(xiàng)目將采用一系列分子生物學(xué)分析，以及多種固定和活體成像方法，使用超分辨率和共聚焦顯微鏡來研究HIV-1顆粒如何在感染細(xì)胞內(nèi)移動(dòng)，包括自然靶細(xì)胞類型，如腦內(nèi)駐留的小膠質(zhì)細(xì)胞和初級(jí)巨噬細(xì)胞。我們的目標(biāo)是了解微管、微管動(dòng)力學(xué)調(diào)節(jié)器和微管運(yùn)動(dòng)蛋白如何發(fā)揮作用以使HIV-1在核內(nèi)外移動(dòng)的分子基礎(chǔ)。

　　英文原文：

　　Postdoctoral position in Virology/Cell Biology

　　Postdoctoral positions are available on NIH funded research projects to study the function of microtubule-associated and microtubule regulatory proteins and their role in viral infection in the Naghavi. Dr. Naghavi is an Associate Professor at the Department of Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago. The Feinberg School of Medicine is located in the center of downtown Chicago. Additional information about the Naghavi lab can be found at http://labs.feinberg.northwestern.edu/naghavi/

　　Our previous studies have established how HIV-1 controls microtubule behavior to facilitate infection, and the host factors involved. This includes microtubule motor-associated adaptor proteins, as well as specialized microtubule plus-end tracking proteins (called +TIPs) that control the formation of stable microtubule filaments and facilitate HIV-1 infection. Projects will employ a range of molecular biological assays, as well as a variety of fixed and live imaging approaches using super resolution and confocal microscopy to study how HIV-1 particles move within infected cells, including natural target cell types such as brain resident microglia and primary macrophages. Our goal is to understand the molecular basis behind how microtubules, regulators of microtubule dynamics and microtubule motor proteins function to enable HIV-1 movement to and from the nucleus.

　　Candidates must have a PhD or equivalent with strong research experience in virology, cell biology and/or molecular biology. Applicants with experience in fluorescence microscopy and live imaging are particularly encouraged to apply. Intersted applicants should submit a complete CV, a brief description of their research achievements and interests, and the name and contact details for three referees to:

　　Mojgan.Naghavi@Northwestern.edu

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