招聘簡(jiǎn)介：

　　舊金山加利福尼亞大學(xué)

　　醫(yī)學(xué)部肺與危重病治療科

　　一位積極性很高的科學(xué)家可以利用基因工程小鼠、細(xì)胞系和人類樣本的組合來研究氣道平滑肌中與疾病相關(guān)的力傳遞的基本生物學(xué)。該小組正致力于開發(fā)新的治療方法，通過結(jié)合體外收縮試驗(yàn)、體內(nèi)氣道高反應(yīng)性評(píng)估和雙光子顯微鏡，來針對(duì)哮喘患者氣道平滑肌過度收縮進(jìn)行治療。我們小組的一個(gè)主要焦點(diǎn)是利用已建立的多學(xué)科合作將我們的發(fā)現(xiàn)轉(zhuǎn)化為治療學(xué)，以開發(fā)和篩選有效的靶蛋白小分子抑制劑。感興趣的候選人可以查看我們小組最近的代表性出版物：Sundaram等人JCI2017。

　　英文原文：

　　University of California, San Francisco

　　Division of Pulmonary & Critical Care, Department of Medicine

　　A postdoctoral position is available for a highly motivated scientist to focus on the basic biology of force transmission in airway smooth muscle with disease relevance using a combination of genetically engineered mice, cell lines, and human samples. The group is working to develop novel therapeutic approaches to target excessive airway smooth muscle contraction in asthma using a combination of ex vivo contraction assays, in vivo assessments of airway hyperresponsiveness, and two-photon microscopy. A major focus of our group is to translate our findings into therapeutics using established multidisciplinary collaborations to develop and screen potent small molecule inhibitors of target proteins. Interested candidates can review a representative recent publication from our group: Sundaram et al. JCI2017.

　　Career development opportunities include development of scientific presentation, writing skills, and presentation at national and international meetings. Requirements include:

　　o    Ph.D., M.D. or M.D./Ph.D. degree and fluency in English

　　o    Highly proficient in a variety of basic molecular biology and cell biology techniques evident by peer-reviewed publications

　　o    Demonstrated ability to work as part of a team and independently develop, guide, and complete research projects

　　o    Strong ability to troubleshoot experiments and solve problems

　　o    Experience with mouse husbandry, cell culture, imaging, and flow cytometry preferred

　　Candidates should be self-motivated, critical thinkers, collegial, and creative. Interested candidates should send a brief statement of career goals and research interests, updated CV, along with the name and contact information of three references to Dr. Aparna Sundaram at: aparna.sundaram@ucsf.edu

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