招聘簡介：

　　高級博士后研究員

　　申請被邀請一位博士后研究員加入位于英國諾里奇的約翰·因尼斯中心的卡羅琳·迪恩教授的實(shí)驗(yàn)室。

　　具有豐富博士后經(jīng)驗(yàn)的候選人將被考慮擔(dān)任SC5級的高級博士后研究員職位。在其職業(yè)生涯早期階段的候選人將被考慮擔(dān)任SC6級的博士后研究員職位。

　　背景：

　　約翰·因尼斯中心是一個獨(dú)立的國際植物科學(xué)、遺傳學(xué)和微生物學(xué)卓越中心。

　　DEAN小組的總體目標(biāo)是了解什么能定量地調(diào)節(jié)熱環(huán)境中的sflc表達(dá)，以及如何在冷環(huán)境中轉(zhuǎn)換為表觀靜默狀態(tài)。（https://www.jic.ac.uk/people/caroline-dean/）

　　角色：

　　成功的候選人將研究擬南芥基因座FLC的表觀遺傳轉(zhuǎn)換機(jī)制。這個位點(diǎn)為研究組蛋白修飾、非編碼RNA和轉(zhuǎn)錄動力學(xué)之間的基本染色質(zhì)途徑提供了一個很好的系統(tǒng)。

　　該項(xiàng)目將涉及到在長時間暴露于寒冷之前、期間和之后解剖不同的機(jī)制，通過其反義RNA（COOLAIR）調(diào)節(jié)FLC的表達(dá)。

　　英文原文：

　　Senior – Postdoctoral Researcher

　　Applications are invited for a Postdoctoral Researcher to join the Laboratory of Professor Caroline Dean at the John Innes Centre based in Norwich, UK.

　　Candidates with substantial postdoctoral experience will be considered for the Senior Postdoctoral Researcher post, at grade SC5. Candidates at an earlier stage in their career will be considered for the Postdoctoral Researcher post, at grade SC6.

　　Background:

　　The John Innes Centre is an independent, international centre of excellence in plant science, genetics and microbiology.

　　The overall aim of the Dean group is to understand what quantitatively regulatesFLC expression in the warm, and how it is switched to an epigenetically silent state in the cold. (https://www.jic.ac.uk/people/caroline-dean/)

　　The role:

　　The successful candidate will study the mechanism of epigenetic switching at the Arabidopsis locus FLC. This locus provides an excellent system to study fundamental chromatin pathways linking histone modifications, non-coding RNA and transcriptional dynamics.

　　The project will involve dissection of the different mechanisms by which expression of FLC is regulated by its antisense RNA (COOLAIR), before, during and after exposure to prolonged cold.

　　The ideal candidate:

　　Candidates should possess a PhD in molecular biology/cell biology, with experience in chromatin analysis and confocal microscopy (SC5 and SC6). A proven record in scientific writing is essential, as is experience of oral research presentations. In order to be considered for the senior post (SC5), candidates should have demonstrated excellence and productivity in the relevant science and ideally possess skills in live imaging and super resolution microscopy.

　　Additional information:

　　Appointments made at Postdoctoral Researcher level (SC6) will attract an annual salary of £31,250 – £38,100. Appointments made at Senior Postdoctoral Researcher level (SC5) will attract an annual salary of £39,150 – £47,850. Salaries are dependent on qualifications and experience.

　　This is a fulltime post for a period of 3 years in the first instance.

　　Interviews will be held on 10th July 2019.

　　For further information and details of how to apply, please visit our web site http://jobs.jic.ac.uk or contact the Human Resources team on 01603 450462 or nbi.recruitment@nbi.ac.uk quoting reference 1003696.

　　We are an equal opportunities employer, actively supporting inclusivity and diversity. As a Disability Confident organisation, we guarantee to offer an interview to all disabled applicants who meet the essential criteria for this vacancy. The John Innes Centre is also proud to hold a Gold Award from Athena SWAN and is a member of Stonewall’s Diversity Champions programme.

　　The closing date for applications will be 16th June 2019.

　　The John Innes Centre is a registered charity (No. 223852) grant-aided by the Biotechnology and Biological Sciences Research Council and is an Equal Opportunities Employer.

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